Potassium-induced enhancement of persistent inward current in hippocampal neurons in isolation and in tissue slices

Brain Research

Volumn 885, Issue 1, 2000, Pages 102-110

  Somjen, G G ^a   Muller M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Excitable membranes and synaptic transmission; External potassium; Intracellular calcium; Persistent sodium current; Seizure; Sodium channel; Sodium channels; Spreading depression

Indexed keywords

CALCIUM; POTASSIUM; SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FLUORESCENCE; HIPPOCAMPUS; MEMBRANE DEPOLARIZATION; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SODIUM CURRENT; SPREADING CORTICAL DEPRESSION; SYNAPTIC TRANSMISSION;

ANIMALS; CALCIUM; EPILEPSY; FEEDBACK; HIPPOCAMPUS; LASERS; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; NEURONS; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; POTASSIUM; RATS; SEIZURES; SODIUM; SODIUM CHANNELS; SPREADING CORTICAL DEPRESSION; TETRODOTOXIN;

EID: 0034575581     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02948-6     Document Type: Article

References (45)

1. Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically
2. Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex
3. JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements
4. Cardiac ionic currents and acute ischemia: from channels to arrhythmias
5. Interstitial space, electrical resistance and ion concentrations during hypotonia of hippocampal slices of rats
6. Persistent sodium current in mammalian central neurons
7. Membrane currents in CA1 hippocampal cells during spreading depression (SD) and SD-like hypoxic depolarization
8. Electrolyte disturbances in chronic heart failure: metabolic and clinical aspects
9. Calcium dependence of synaptic transmission in the hippocampal slice
10. Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro
11. Potassium accumulation in interstitial space during epileptiform seizures
12. A voltage-dependent persistent sodium current in mammalian hippocampal neurons
13. In vivo elevation of extracellular potassium in the rat amygdala increases extracellular glutamate and aspartate and damages neurons
14. A consideration of feedback mechanisms in the genesis and maintenance of hippocampal seizure activity
15. Investigation on the mechanism of epileptic discharge in the hippocampus
16. Mechanism of spreading cortical depression
17. The hippocampus
18. Inhibition of oxidative metabolism increases persistent sodium current in rat CA1 hippocampal neurons
19. Effects of anoxia on ion distribution in the brain
20. Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex
21. Extracellular free calcium and potassium during paroxysmal activity in the cerebral cortex of the cat
22. Analysis of potential shifts associated with recurrent spreading depression and prolonged unstable SD induced by microdialysis of elevated K+ in hippocampus of anesthetized rats
23. Anomalous inward rectification in hippocampal neurons
24. Enhancement of whole-cell synaptic current by low osmolarity and by low [NaCl] in rat hippocampal slices
25. Hypoxia increases persistent sodium current in rat ventricular myocytes
26. Simulated seizure discharges and spreading depression-like depolarization in a neuron model incorporating interstitial space and ion concentration changes
27. Isolation of neurons suitable for patch clamping from adult mammalian central nervous system
28. Persistent sodium currents through brain sodium channels induced by G protein betagamma subunits
29. Spreading cortical depression of Leao
30. Evidence for persistent Na+ current in apical dendrites of rat neocortical neurons from imaging of Na+-sensitive dye
31. Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like deplarization
32. + concentrations, extra- and intracellular voltages and the effect of TTX in hypoxic rat hippocampal slices
33. Outward currents of single hippocampal cells obtained from the adult guinea pig
34. +](o) potentiate persistent sodium current in isolated hippocampal neurons
35. The ionic and metabolic responses associated with neuronal depression of Leao's type in cerebral cortex and in hippocampal formation
36. Sustained potential shifts and paroxysmal discharges in hippocampal formation
37. Potassium and calcium concentrations in interstitial fluid of hippocampal formation during paroxysmal responses
38. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake
39. + currents that fail to inactivate
40. Spreading cortical convulsions and depressions
41. Current source density of sustained potential shifts associated with electrographic seizures and with spreading depression in rat hippocampus