Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats

Biogerontology

Volumn 1, Issue 1, 2000, Pages 55-59

  Anisimov, Vladimir N ^a   Khavinson, Vladimir Kh ^b   Morozov, Vyacheslav G ^b  

^a N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

^b Institute of Bioregulation and Gerontology   (Russian Federation)

Author keywords

Dipeptide; Life span; Rat; Thymus; Tumorigenesis

Indexed keywords

DIPEPTIDE; IMMUNOLOGICAL ADJUVANT; PEPTIDE; THYMOGEN;

AGING; ANIMAL; ARTICLE; CBA MOUSE; DRUG EFFECT; FEMALE; MOUSE; NEOPLASM; RAT; SHEEP; SYNTHESIS; TISSUE DISTRIBUTION;

ADJUVANTS, IMMUNOLOGIC; AGING; ANIMALS; DIPEPTIDES; FEMALE; MICE; MICE, INBRED CBA; NEOPLASMS; PEPTIDES; RATS; SHEEP; TISSUE DISTRIBUTION;

EID: 0034575024     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010042008969     Document Type: Article

References (18)

1. Anisimov VN (1987) Carcinogenesis and Aging, Vol. 2. CRC Press, Boca Raton, Florida
2. Anisimov VN (1998) Age as a risk factor in multistage carcinogenesis. In: Balducci L, Ershler WB and Lyman GH (eds) Comprehensive Geriatric Oncology, pp 157-178. Harwood, Amsterdam
3. Anisimov VN, Khavinson VKh and Morozov VG (1982) Carcinogenesis and aging. IV Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice. Mech Ageing Dev 19: 245-258
4. Anisimov VN, Loktionov AS, Khavinson VKh and Morozov VG (1989) Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age. Mech Ageing Dev 49: 245-257
5. Anisimov VN, Pliss GB, Iogannsen MG, Popovich IG, Romanov KP, Monakhov AS and Averyanova TK (1989a) Spontaneous tumors in outbred LIO rats. J Exp Clin Cancer Res 8: 254-262
6. Gart JJ, Krewski D, Lee PN, Tarone RE and Wahrendorf J (eds) (1986) Statistical Methods in Cancer Research. Volume III - The Design and Analysis of Long-Term Animal Experiments. IARC Sci. Publ. No. 79. IARC, Lyon
7. Ghanta VK, Hiramoto NS, Soong S-J and Hiramoto RN (1991) Survey of thymic hormone effects on physical and immunological parameters in C57BL/6NNia mice of different ages. Ann NY Acad Sci 621: 239-255
8. Kay MMH and Makinodan T (1986) Handbook of Immunology of Aging. CRC Press, Boca Raton, Florida
9. Morozov VG and Khavinson VKh (1978) Characteristics and study of mechanisms of action of thymic factor (thymarin). Dokl Akad Nauk SSSR 240: 1004-1007
10. Morozov VG and Khavinson VKh (1991) Thymus-gland preparation and method for producing same. United States Patent No 5,070,076
11. Morozov VG and Khavinson VKh (1996a) Pharmaceutical preparation for the therapy of immune deficiency conditions. United States Patent No 5,538,951
12. Morozov VG and Khavinson VKh (1996b) Peptide Bioregulators (25 Years of Experimental and Clinical Study). Nauka, St. Petersburg
13. Morozov VG and Khavinson VKh (1997) Natural and synthetic thymic peptides as therapeutics for immune dysfunction. Int J Immunopharmacol 19: 501-505
14. Morozov VG, Khavinson VKh and Pisarev OA (1977) Isolation and origin study of immunogenesis stimulating thymic factor. Dokl Akad Nauk SSSR 233: 491-494
15. Morozov VG, Ivanov KS, Sheyback VV and Kasyanov AD (1994) The use of thymic peptides for patients with undetermined human immunodeficiency virus test results. In: Masihi D (ed) Immunotherapy of Infections, pp 135-141. Marcel Dekker, New York
16. Turusov VS and Mohr U (eds) (1990) Pathology of Tumours in Laboratory Animals, Volume 1 - Tumours of the Rat. Second edition, IARC Sci. Publ No 99. IARC, Lyon
17. Walford RY (1974) Immunologic theory of aging. Fed Proc 33: 2020-2027
18. Zatz MM and Goldstein AL (1985) Thymosins, lymphokines, and the immunology of aging. Gerontology 31: 263-277