Humane endpoints for genetically engineered animal models

ILAR Journal

Volumn 41, Issue 2, 2000, Pages 94-98

  Dennis Jr , Melvin B ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ANIMAL WELFARE; DISEASE MODEL; EXPERIMENTAL ANIMAL; GENETIC ENGINEERING; GENETICS; LABORATORY; METHODOLOGY; MOUSE; PHYSIOLOGY; REVIEW; TRANSGENIC MOUSE;

ANIMAL WELFARE; ANIMALS; ANIMALS, LABORATORY; DISEASE MODELS, ANIMAL; GENETIC ENGINEERING; LABORATORY ANIMAL SCIENCE; MICE; MICE, TRANSGENIC;

EID: 0034574048     PISSN: 10842020     EISSN: None     Source Type: Journal    
DOI: 10.1093/ilar.41.2.94     Document Type: Article

References (24)

1. Boivin GP, O'Toole BA, Ormsby IE, Diebold RJ, Eis MJ, Doetschman T, Kier AB. 1995. Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice. Am J Pathol 146:276-288.
2. CFR [Code of Federal Regulations]. 1998. Title 9 (Animals and Animal Products), Subchapter A (Animal Welfare) (9 CFR 1-4).
3. Chong H, Starkey W, Vile RG. 1998. A replication-competent retrovirus arising from a split-function packaging cell line was generated by recombination events between the vector, one of the packaging constructs, and endogenous retroviral sequences. J Virol 72:2663-2670.
4. Costa P. 1996. Neuro-behavioural tests in welfare assessment of transgenic animals. In: O'Donoghue PN, ed. Sixth FELASA Symposium: Harmonization of Laboratory Animal Husbandry. London. Royal Society of Medicine Press. p 51-53.
5. Crawley JN, Paylor R. 1997. A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm Behav 31:197-211.
6. Dennis MB Jr. 1999. Institutional animal care and use committee review of genetic engineering. In: Gonder JC, Prentice ED, Russow LM, editors. Genetic Engineering and Animal Welfare: Preparing for the 21st Century. Greenbelt MD: SCAW. p 20-31.
7. Dennis MB Jr, Van Hoosier GL Jr. 1994. North American legislation and regulation of the use of live animals in scientific research. In: Svendsen P, Hau J, editors. Selection and Handling of Animals in Biomedical Research. Vol 1 of Handbook of Laboratory Animal Science. CRC Press. p 23-36.
8. Federal Register. 1994. Guidelines for Research Involving Recombinant DNA. Vol 59, July 5, Separate Part IV.
9. Lewis DB, Liggitt HD, Effmann EL, Motley ST, Teitelbaum SL, Jepsen KJ, Goldstein SA, Bonadio J, Carpenter J, Perlmutter RM. 1993. Osteoporosis induced in mice by overproduction of interleukin 4. Proc Natl Acad Sci U S A 90:11618-11622.
10. Liu Y, Liggitt D, Zhong W, Tu G, Gaensler K, Debs R. 1995. Cationic liposome-mediated intravenous gene delivery. J Biol Chem 270:24864-24870.
11. Makrides SC. 1999. Components of vectors for gene transfer and expression in mammalian cells. Protein Exp Pur 17:183-202.
12. McNeish JD, Scott WJ, Potter SS. 1988. Legless, a novel mutation found in PHTI-1 transgenic mice. Science 241:837-839.
13. Murphy ED, Roths JB. 1978. Purkinje cell degeneration, a late effect of beige mutations in mice. Annu Rep Jackson Lab 49:108-109.
14. NRC [National Research Council]. 1996. Guide for the Care and Use of Laboratory Animals. Washington DC: National Academy Press.
15. Pinkert CA. Editor. 1994. Transgenic Animal Technology: A Laboratory Handbook. Orlando: Academic Press.
16. Pursel VG, Pinkert CA, Miller KF, Bolt DJ, Campbell RG, Palmiter RD, Brinster RL, Hamer RE. 1989. Genetic engineering of livestock. Science 244:1281-1288.
17. Roths JB, Foxworth WB, McArthur MJ, Montgomery CA, Kier AB. 1999. Spontaneous and engineered mutant mice as models for experimental and comparative pathology: History, comparison, and developmental technology. Lab Anim Sci 49:12-34.
18. Shockett PE, Schatz DG. 1996. Diverse strategies for tetracycline-regulated inducible gene expression. Proc Natl Acad Sci U S A 93:5173-5176.
19. Silver LM. 1995. Mouse Genetics: Concepts and Applications, New York: Oxford University Press.
20. Szczypka MS, Mandel RJ, Donahue BA, Snyder RO, Leff SE, Palmiter RD. 1999. Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice. Neuron 22:167-178.
21. van der Meer M, van Zutphen LFM. 1995. Use of transgenic animals and welfare considerations. In: van Zutphen LFM, van der Meer M, editors. Welfare Aspects of Transgenic Animals. Berlin: Springer-Verlag, p 78-89.
22. Wolf E, Wanke R. 1995. Growth hormone overproduction in transgenic mice: Phenotypic alterations and deduced animal models. In: van Zutphen LFM, van der Meer M, eds. Welfare Aspects of Transgenic Animals. Berlin: Springer-Verlag, p 26-47.
23. Zhou QY, Palmiter RD. 1995. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83:1197-1209.
24. Zhou QY, Quaife CJ, Palmiter RD. 1995. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 13:640-643.