Clinical aspects and perspectives in islet xenotransplantation

Journal of Hepato-Biliary-Pancreatic Surgery

Volumn 7, Issue 4, 2000, Pages 364-369

  GrotH, Carl G ^a   Tibeli, Annika ^a   WennberG, Lars ^a   Bennet, William ^a   LundgreN, Torbjörn ^a   Rydgård, Karl Johan ^a   Lundin, Susanne ^c   Lindeborg, Ellinor ^d   Korsgren, Olle ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Clinical xenoislet transplantation; Porcine endogenous retrovirus; Xenoantibodies

Indexed keywords

ANIMAL; ARTICLE; FOLLOW UP; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TRANSPLANTATION; PANCREAS ISLET TRANSPLANTATION; SWINE; XENOGRAFT;

ANIMALS; DIABETES MELLITUS, TYPE 1; FOLLOW-UP STUDIES; HUMANS; ISLETS OF LANGERHANS TRANSPLANTATION; KIDNEY TRANSPLANTATION; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0034573716     PISSN: 09441166     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005340070030     Document Type: Article

References (19)

1. Groth CG. Korsgren O, Tibell A, Tollemar J. Möller E. Bolinder J, Östman J, Reinholt F, Hellerström C, Andersson A (1994) Transplantation of porcine fetal pancreas to diabetic patients. Lancet 344:1402-1404
2. Korsgren O, Sandler S, Schnell Landström A, Jansson L. Andersson A (1988) Large-scale production of fetal porcine pancreatic islet-like cell clusters. Transplantation 45:509-514
3. Korsgren O, Jansson L, Eizirik D. Andersson A (1991) Functional and morphological differentiation of fetal porcine islet-like cell clusters after transplantation into nude mice. Diabetologia 34:379-386
4. Tollemar J. Groth CG, Korsgren O. Andersson A. Blombäck M. Olsson P (1992) Injection of xenogeneic endocrine pancreatic Ii-MtO into the portal vein - effects on coagulation, liver function. and hepatic hemodynamics. Transplantation 53:139-142
5. Bjiicrsdorff A. Korsgren O. Feinstein R. Andersson A. Tollemar J. Malmborg A-S. Ehrnst A, Groth CG (1995) Microbiological characterization of porcine fetal islet-like cell clu-ters for intended clinical xenografting. Xenotransplantation 2: 26-31
6. Reinholt FP. Hultenby K.Tibell A, Korsgren O. Groth CG (1998) Survival of fetal porcine pancreatic islet tissue transplanted to a diabetic patient: findings by ultrastructural immunocyto-chemistry. Xenotransplantation 5:222-225
7. Satake M. Kumagai-Braesch M, Kawagishi N, Tibell A, Groth CG, Möller E (1994) Kinetics and character of xenoantibody formation in diabetic patients transplanted with fetal porcine islet cell clusters. Xenotransplantation 1:24-35
8. Satake M, Kawagishi N. Rydberg L, Samuelsson BE, Tibell A. Groth CG Möller E (1994) Limited specificity of xenoantibodics in diabetic patients transplanted with fetal porcine islet cell clusters. Main antibody reactivity against a-linked galactose-containing epitopcs. Xenotransplantalion 1:89-101
9. Kumagai-Braesch M, Satake M. Qian Y, Holgersson J, Möller E (1998) Human NK cell and ADCC reactivity against xenogeneic porcine target cells including fetal porcine islet cells. Xenotransplantation 5:132-145
10. Galili U, Tibell A. Samuelsson BE, Rydberg L, Groth CG (1995) Increased anti-gal activity in diabetic patients transplanted with fetal porcine islet cell clusters. Transplantation 59:1549-1556
11. Kumagai-Breasch M. Lindeborg E, Tibell A, Groth CG, Möller E (1999) Characterization of long-term humoral xcnoimmunity in diabetic patients transplanted with fetal pig islet cells. Fifth Congress of the International Xenotransplantation Association, Nagoya, 1999
12. Lindeborg E, Kumagai-Braesch M, Tibell A, Groth CG. Möller E (1999) Subclass distribution and immunological specificity of xenoimmune antibodies in diabetic patients transplanted with fetal pig islet cells. Fifth Congress of the International Xenotransplantation Association. Nagoya. 1999
13. Tibell A. Blomqvist G. Andcrsson J. Erdman D. Klingeborn H (1999) Serological analyses for porcine viruses after xenoislct transplantation - an up-date. Fifth Congress of the International Xenotransplantation Association. Nagoya. 1999
14. Hencine W, Tibell A. Switzer WM. Sandstrom P. Rosales GV. Mathews A. Korsgren O. Chapman LE. Folks TM. Groth CG (1998) No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts. Lancet 352:695-699
15. Lundin S (1999) The boundless body: cultural perspectives on Xenotransplantation. Ethnos 64:1-8
16. Lehncrt AM, Cowan P, Salvaris E. Burgess J. d'Apice AJF. O'Connell PJ (1999) High titre anti-gai antibodies cause islet graft rejection. Fifth Congress of the International Xenotrans-plantation Association, Nagoya. 1999
17. Wennberg L. Song Z, Zhang J, Bennet W. Nava S, Sundberg B. Bari S. Groth CG, Korsgren O (1999) Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine A, mycophenolatc mofetil and lcHunomide remain normoglycemic for up to 100 days. Transplantation, (in press)
18. Bennet W, Sundherg B. Lundgren T, Tibell A. Groth CG. Richards A. White DJ, Elgue G. Larsson R. Nilsson B, Korsgren O (1999) Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomolgus monkey: protective effects of sCRl and hcparin. Transplantation 69:711-719
19. Paradis K. Langford O. Long Z, Hencine W, Sandstrom P. Switzer WM. Chapman LE, Lockey C, Unions D, the XENI11 Study Group, Otto C (1999) Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 285:1236-1241