Dietary fat intake, supplements, and weight loss

Canadian Journal of Applied Physiology

Volumn 25, Issue 6, 2000, Pages 495-523

  Dyck, David J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Carnitine; Conjugated linoleic acid; Ephedrine; Hydroxycitrate; Pyruvate

Indexed keywords

ACETYLSALICYLIC ACID; ANTIOBESITY AGENT; CARNITINE; CITRIC ACID; EPHEDRINE; HYDROXYCITRIC ACID; INSULIN; LEPTIN; LINOLEIC ACID; METHYLXANTHINE; PYRUVIC ACID DERIVATIVE; TRIACYLGLYCEROL; XANTHINE DERIVATIVE;

ANIMAL; BLOOD; DIET SUPPLEMENTATION; FAT INTAKE; HUMAN; LIPID METABOLISM; LIPOLYSIS; METABOLISM; MOUSE; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER; OBESITY; OXIDATION REDUCTION REACTION; RAT; REVIEW; SKELETAL MUSCLE; WEIGHT REDUCTION;

NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER;

ANIMALS; ANTI-OBESITY AGENTS; ASPIRIN; CARNITINE; CITRATES; DIETARY FATS; DIETARY SUPPLEMENTS; EPHEDRINE; HUMANS; INSULIN; LEPTIN; LINOLEIC ACID; LIPID METABOLISM; LIPOLYSIS; MICE; MUSCLE, SKELETAL; OBESITY; OXIDATION-REDUCTION; PYRUVATES; RATS; TRIGLYCERIDES; WEIGHT LOSS; XANTHINES;

EID: 0034571722     PISSN: 10667814     EISSN: None     Source Type: Journal    
DOI: 10.1139/h00-033     Document Type: Article

References (159)

1. Aarsland, A.D., Chinkes, D., and Wolfe, R.R. (1997). Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding. Am. J. Clin. Nutr. 65: 1774-1782.
2. Abbott, W.G.H., Howard, B.V., and Christin, L. (1988). Short-term energy balance: Relationship with protein, carbohydrate, and fat balances. Am. J. Physiol. (Endocrinol. Metab.) 255: E322-E327.
3. Acheson, K.J., Schutz, Y., Bessard, T., Anantharaman, K., Flatt, J.P., and Jequier, E. (1988). Glycogen storage capacityand de novo lipogenesis during massive carbohydrate over-feeding man. Am. J. Clin. Nutr. 48: 240-247.
4. Arenas, J., Huertas, R., Campos, Y., Diaz, A.E., Villalon, J.M., and Vilas, E. (1994). Effects of L-carnitine on the pyruvate dehydrogenase complex and carnitine palmitoyl transferase activities in muscle of endurance athletes. FEBS Lett. 341(1): 91-93.
5. Arenas, J., Ricoy, J.R., Encinal, A.R., Pola, P., D'iddio, S., Zeviani, M., Didonato, S., and Corsi, M. (1991). Carnitine in muscle, serum, and urine of nonprofessional athletes: Effects of physical exercise, training, and L-carnitine administration. Muscle & Nerve 14: 598-604.
6. Astrup, A. (1995). The sympathetic nervous system as a target for intervention in obesity. Int. J. Obesity 19(Suppl. 7): S24-S28.
7. Astrup, A., Breum, L., Toubro, S., Hein, P., and Quaade, F. (1992a). The effect and safety of an ephedrine/caffine compound compared to ephedrine, caffeine and placebo in obese subjecs on an energy restricted diet. A double blind trial. Int. J. Obesity 16: 269-277.
8. Astrup, A., Buemann, B., Christensen, N.J., Toubro, S., Thorbek, G., Victor, O.J., and Quaade, F. (1992b). The effect of ephedrine/caffeine mixture on energy expenditure and body composition in obese women. Metabolism 41: 686-688.
9. Astrup, A., Lundsgaard, C., Madsen, J., and Christensen, N.J. (1985). Enhanced thermogenic responsiveness during chronic ephedrine treatment in man. Am. J. Clin. Nutr. 42: 83-94.
10. Bao, S., Kennedy, A., Wojciechowski, B., Wallace, P., Ganaway, E., and Garvey, W.T. (1998). Expression of mRNAs encoding uncoupling proteins in human skeletal muscle: Effects of obesity and diabetes. Diabetes 47: 1935-1940.
11. Barrows, K., and Snook, J.T. (1987). Effect of a high-protein, very-low-calorie diet on body composition and anthropometric parameters of obese middle-aged women. Am. J. Clin. Nutr. 45: 381-90.
12. Bianco, A., Sheng, X., and Silva, J.E. (1988). Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J. Biol. Chem. 263: 18168-18175.
13. Boden, G., and Chen, X. (1999). Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. Diabetes 48: 577-583.
14. Branco, M., Ribeiro, M., Negrao, N., and Bianco, A.C. (1999). 3,5,3′-Triiodothronine actively stimulates UCP in brown fat under minimal sympathetic activity. Am. J. Physiol. (Endocrinol. Metab.) 276: E179-E187.
15. Bray, G.A., and Popkin, B.M. (1998). Dietary fat intake does affect obesity. Am. J. Clin. Nutr. 68: 1157-1173.
16. Brodie, A.E., Manning, V.A., Ferguson, K.R., Jewell, D.E., and Hu, C.Y. (1999). Conjugated linoleic acid inhibits differentiation of pre- and post-confluent 3T3-L1 preadipocytes but unhibits cell proliferation only in preconfluent cells. J. Nutr. 129: 602-606.
17. Brown, M.R., Klish, W.J., Hollander, J., Campbell, M.A., and Forbes, G.B. (1983). A high protein, low calorie liquid diet in the treatment of very obese adolescents: Long-term effect on lean body mass. Am. J. Clin. Nutr. 38(1): 20-31.
18. Brunengraber, H., and Lowenstein, J.M. (1976). Effect of (-)-hydroxycitrate on ketone production by the perfused liver. FEBS Lett. 65: 251-253.
19. Clarkson, P.M. (1998). Dietary supplements and pharmaceutical agents for weight loss and gain. In: D.R. Lamb and R. Murray (Eds.), Exercise, Nutrition, and Weight Control, pp. 349-400. Carmel, IN: Cooper Publishing Group.
20. Colditz, G.A., Willett, W.C., Rotnitzky, A., and Manson, J.E. (1995). Weight gain as a risk factor for clinical diabetes in women. Ann. Intern. Med. 122: 481-486.
21. Colombani, P., Wenk, C., Kuntz, I., Krahenbuhl, S., Kuntz, M., Arnold, M., Frey-Rindova, P., Frey, W., and Langhans, W. (1995). Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: A double-blind crossover field study. Eur. J. Appl. Physiol. 73: 434-439.
22. Commins, S.P., Watson, P.M., Padgett, M.A., Dudley, A., Argyropoulos, G., and Gettys, T.W. (1999). Induction of uncoupling protein expression in brown and white adipose tissue by leptin. Endocrinology 140(1): 292-300.
23. Constantin-Teodosiu, D., Simpson, E.J., and Greenhaf, P.L. (1999). The importance of pyruvate availability to PDC activation and anaplerosis in human skeletal muscle. Am. J. Physiol. (Endocrinol. Metab.) 276: E472-E478.
24. Conte, A.A. (1993). A non-prescription alternative on weight reduction therapy. Am. J. Bariatr. Med. Summer: 17-19.
25. Cortez, M.Y., Torgan, C.E., Brozinick Jr., J.T., Miller, R.H., and Ivy, J.L. (1991). Effect of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats. Am. J. Clin. Nutr. 53: 847-853.
26. Cortright, R.N., Zheng, D., Jones, J.P., Fluckey, J.D., DiCarlo, S.E., Grujic, D., Lowell, B.B., and Dohm, G.L. (1999). Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation. Am. J. Physiol. (Endocrinol. Metab.) 276: E217-E221.
27. Coulston, A.M., Liu, G.C., and Reaven, G.M. (1983). Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans. Metabolism 32(1): 52-56.
28. Cunningham, W.A., and Nicholls, D.G. (1987). Induction of functional uncoupling protein in guinea pigs infused with noradrenaline. Studies with isolated brown adipocytes. Biochem. J. 245: 485-491.
29. Daly, P.A., Krieger, D.R., Dulloo, A.G., Young, J.B., and Landsberg, L. (1993). Ephedrine, caffeine and aspirin: Safety and efficacy for treatment of human obesity. Int. J. Obesity 17: S73-S78.
30. Decombaz, J., Deriaz, O., Acheson, K., Gmuender, B., and Jequier, E. (1993). Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen. Med. Sci. Sports Exerc. 25: 733-740.
31. Decombaz, J.E., Reffet, B., and Bloemhard, Y. (1987). L-carnitine supplementation, caffeine and fuel oxidation in the exercising rat. Nutr. Res. 7: 923-933.
32. Decombaz, J.E., Reffet, B., and Bloemhard, Y. (1990). Effect of L-carnitine and stimulated lipolysis on muscle substrates in the exercising rat. Experientia 46: 457-458.
33. Delany, J.P., Blohm, F., Truett, A.A., Scimeca, J.A., and West, D.B. (1999). Conjugated linoleic acid rapidly reduced body fat content in mice without affecting energy intake. Am. J. Physiol. (Regulatory Integrative Comp. Physiol.) 276: R1172-R1179.
34. Dobson, G.P., Yamamoto, E., and Hochochka, P.W. (1986). Phosphofructokinase control in muscle: Nature and reversal of pH-dependent ATP inhibition. Am. J. Physiol. (Regulatory, Integrative, Comp. Physiol.) 19: R71-R76.
35. Donahue, R.P., Abbott, R.D., Bloom, E., Reed, D.M., and Yano, K. (1987). The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease. The Paris prospective study. Int. J. Obes. 10: 229-240.
36. Dubelaar, M.-L., Lucas, C.M.H.B., and Hulsmann, W.C. (1991). Acute effect of L-carnitine on skeletal muscle force tests on dogs. Am. J. Physiol. (Endocrinol. Metab.) 260: E189-E193.
37. Dulloo, A.G., and Miller, D.S. (1986). The thermogenic properties of ephedrine/ methylxanthine mixtures: Human studies. Int. J. Obesity 10: 467-481.
38. Dulloo, A.G., and Miller, D.S. (1987). Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity. Am. J. Clin. Nutr. 45: 564-569.
39. Dulloo, A.G., Seydoux, J., and Girardier, L. (1991). Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue. Int. J. Obesity 15: 317-326.
40. Flatt, J.P. (1987a). Dietary fat, carbohydrate balance and weight maintenance: Effects of exercise. Am. J. Clin. Nutr. 45: 296-306.
41. Flatt, J.P. (1987b). The difference in the storage capacities for carbohydrate and for fat, and its implicationsinthe regulation of body weight. Ann. NY Acad Sci 499: 104-123.
42. Flatt, J.P. (1995). Use and storage of carbohydrate and fat. Am. J. Clin. Nutr. 61(Suppl.): 952S-959S.
43. Folsom, A.R., Kaye, S.A., Sellers, T.A., Hong, C.P., Cerhan, J.R., Potter, J.D., and Prineas, R.J. (1993). Body fat distribution and 5-year risk of death in older women. JAMA 269: 483-487.
44. Garland, P.B., Newsholme, E.A., and Randle, P.J. (1964). Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation on pyruvate metabolism and on lactate/pyruvate and L-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscle. Biochem. J. 93: 665-678.
45. Garland, P.B., and Randle, P.J. (1964). Regulation of glucose uptake by muscle. 10. Effects of alloxan-diabetes, starvation, hypothysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-zoenzyme a, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles. Biochem. J. 93: 678-687.
46. Garland, P.B., Randle, P.J., and Newsholme, E.A. (1963). Citrate as an intermediary in the inhibition of phosphofructokinase in rat heart muscle by fatty acids, ketone bodies, pyruvate, diabetes and starvation. Nature 200(October): 169-1963.
47. Girola, M., De Bernardi, M., and Contos, S. (1996). Dose effect in lipid-lowering activity of a new dietary intetrator (chitosan, Garcinia cambogia extract, and chrome). Acta Toxicol. Ther. 17: 25-40.
48. Goheen, S.C., Pearson, E.E., Larkin, E.C., and Rao, G.A. (1981). The prevention of alcoholic fatty liver using dietary supplements: Dihydroxyacetone, pyruvate and riboflavin compared to arachidonic acid in pair-fed rats. Lipids 16: 43-51.
49. Gomez-Ambrosi, J., Fruhbeck, G., and Martinez, J.A. (1999). Leptin, but not a beta 3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: Short-term thermogenic interactions. Cell. Mol. Life Sci. 55: 992-997.
50. Gong, D.-W., He, Y., Karas, M., and Reitman, M. (1997). Uncoupling protein-3 is a mediator of thermogenesis regulated by thryroid hormone, B3-adrenergic agonists, and leptin. J. Biol. Chem. 272: 24129-24312.
51. Gorostiaga, E.M., Maurer, C.A., and Eclache, J.P. (1988). Decrease in respiratory quotient during exercise following L-carnitine supplementation. Int. J. Sports Med. 10(3): 169-174.
52. Graham, T.E., and Adamo, K.B. (1999). Dietary carbohydrate and its effects on metabolism and substrate stores in sedentary and active individuals. Can. J. Appl. Physiol. 24: 393-415.
53. Ha, Y.L., Grimm, N.K., and Parizza, M.W. (1987). Anticarcinogens from fried ground beef: Heat-altered derivatives of linoleic acid. Carcinogenesis 8: 1881-1887.
54. Ha, Y.L., Storkson, J., and Pariza, M.W. (1990). Inhibition of benzo(alpha)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res. 50: 1097-1101.
55. Hagg, S., Taylor, S.I., and Ruderman, N.B. (1976). Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise. Biochem. J. 158: 203-210.
56. Harper, P., Elwin, C.E., and Cederblad, G. (1988). Pharmacokinetics of bolus intravenous and oral doses of L-carnitine in healthy subjects. Eur. J. Clin. Pharmacol. 35: 69-75.
57. Hellerstein, M.K., Christiansen, M., Kaempfer, S., Kletke, C., Wu, K., Reid, J.S., Mulligan, K., Hellerstein, N.S., and Shackleton, C.H. (1991a). Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J. Clin. Invest. 87: 1841-52.
58. Hellerstein, M.K., Wu, K., Kaempfer, S., Kletke, C., and Shackleton, C.H. (1991b). Sampling the lipogenic hepatic acetyl-CoA pool in vivo in the rat. Comparison of xenobiotic probe to values predicted from isotopomeric distribution in circulating lipids and measurement of lipogenesis and acetyl-CoA dilution. J. Biol. Chem. 266: 10912-10919.
59. Hendler, R., and Bonde, A.A.D. (1988). Very-low-calorie diets with high and low protein content: impact on triiodothyronine, energy expenditure, and nitrogen balance. Am. J. Clin. Nutr. 48: 1239-1247.
60. Heymsfield, S.B., Allison, D.B., Vaselli, J.R., Pietrobelli, A., Greenfield, D., and Nunez, C. (1998). Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent. JAMA 280: 1596-1600.
61. Hill, J.O., Drougas, H., and Peters, J.C. (1993). Obesity treatment: Can diet composition play a role? Ann. Intern. Med. 119: 694-697.
62. Hobbs, L.S. (1994). (-)-Hydroxycitrate (HCA). The New Diet Pills. Irvine, CA: Pragmatic Press.
63. Horton, T.J., and Geissler, C.A. (1991). Aspirin potentiates the effect of ephedrine on the thermogenic response to a meal in obese but not lean women. Int. J. Obesity 15: 359-366.
64. Houseknecht, K.L., Vanden Heuvel, J.P., Moya-Camarena, S.Y., Portocarrero, C.P., Peck, L.W., Nickel, K.P., and Belury, M.A. (1998). Dietary conjugated linoleic acid normalized impaired blucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem. Biophys. Res. Commun. 244: 678-682.
65. Ip, C., Chin, S.F., Scimeca, J.A., and Pariza, M.W. (1991). Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res. 51: 6118-6124.
66. Jequier, E., and Tappy, L. (1999). Regulation of body weight in humans. Physiol. Rev. 79: 451-180.
67. Kalman, D., Roufs, J., and Maharam, L.G. (1998). Effects of exogenous pyruvate on body composition and energy levels [Abstract]. Med. Sci. Sports Exer. 30(5): S156.
68. Kannel, W.B., D'Angostino, R.B., and Cobb, J.L. (1996). Effect of weight gain on cardiovascular disease. Am. J. Clin. Nutr. 63(Suppl.): 419S-422S.
69. Kazunori, K.G.C., Lee, Y., and Unger, R. (1997). Tissue triglycerides, insulin resistance, and insulin production: Implications for hyperinsulinemia of obesity. Am. J. Physio. (Endocrinol. Metab. 36) 273: E708-E713.
70. Kelley, D.E., Goodpaster, B., Wing, R.R., and Simoneau, J.-A. (1999). Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am. J. Physiol. (Endocrinol. Metab.) 277: E1130-E1141.
71. Kelley, D.E., and Simoneau, J.-A. (1994). Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 94: 2349-2356.
72. Kendall, A., Levitsky, D.A., Strupp, B.J., and Lissner, L. (1991). Weight loss on a low-fat diet: consequence of the imprecision of the control of food intake in humans. Am. J. Clin. Nutr. 53: 1124-1129.
73. Koyama, K., Chen, G., Lee, Y., and Unger, R.H. (1997). Tissue tryglycerides, insulin resistance, and insulin production: Implications for hyperinsulinemia of obesity. Am. J. Physiol. (Endocrinol. Metab.), 273: E708-E713.
74. Krieger, D.R., Daly, P.A., Dulloo, A.G., Ransil, B.J., Young, J.B., and Landsberg, L. (1990). Ephedrine, caffeine and aspirin promote weight loss in obese subjects. Trans. Assoc. Am. Physicians 103: 307-312.
75. Kuczmarksi, R.J., Flegal, K.M., Campbell, S.M., and Johnson, C.L. (1994). Increasing prevalence of overweight among US adults. JAMA 272: 205-211.
76. Kushner, R.F., Gudivaka, R., and Schoeller, D.A. (1996). Clinical characteristics influencing bioelectrical impedance analysis measuremens. Am. J. Clin. Nutr. 64(Suppl.): 423S-427S.
77. Larsson, B., Svardsudd, K., Welin, L., Wilhemsen, L., Bjorntorp, P., and Tibblin, G. (1984). Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13 year follow-up of participants in the study of men born in 1913. Brit. Med. J. 288: 1401-1404.
78. Lewis, S.B., Wallin, J.D., Kane, J.P., and Gerich, J.E. (1977). Effect of diet composition on metabolic adaptations to hypocaloric nutrition: Comparison of high carbohydrate and high fat isocaloric diets. Am. J. Clin. Nutr. 30: 160-170.
79. Lissner, L., Levitsky, D.A., Strupp, B.J., Kalkwarf, H.J., and Roe, D.A. (1987). Dietary fat and the regulation of energy intake in human subjects. Am. J. Clin. Nutr. 46: 886-892.
80. Liu, Q., Bai, C., Chen, F., Wang, R., MacDonald, T., Gu, M., Zhang, Q., Morsy, M.A., and Caskey, C.T. (1998). Uncoupling protein-3: A muscle-specific gene upregulated by leptin in ob/ob mice. Gene 207(1): 1-7.
81. Lowenstein, J.M. (1971). Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J. Biol. Chem. 246: 629-632.
82. Marconi, C., Sassi, G., Carpinelli, A., and Cerretelli, P. (1985). Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. Eur. J. Appl. Physiol. 54: 131-135.
83. McGarry, J.D. (1995). The mitochondrial carnitine palmitoyl transferase system: Its broadening role in fuel homeostasis and new insights into its molecular features. Biochem. Soc. Trans. 23: 321-324.
84. Morrison, M.A., Spriet, L.L., and Dyck, D.J. (2000). Pyruvate ingestion for seven days does not improve aerobic performance in well trained individuals. J. Appl. Physiol. 89: 549-556.
85. Mory, G., Bouillaud, F., Combes-George, M., and Ricquier, D. (1984). Noradrenaline controls the concentration of the uncoupling protein in brown adipose tissue. FEBS 1192: 393-396.
86. Muoio, D.M., Dohm, G.L., Fiedorek, F.T., Tapscott, E.B., and Coleman, A. (1997). Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46: 1360-1363.
87. Muoio, D.M., Dohm, G.L., Tapscott, E.B., and Coleman, R.A. (1999). Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. Am. J. Physiol. (Endocrinol. Metab.) 276: E913-E921.
88. Nagase, I., Yoshida, T., Kumamoto, K., Umekawa, T., Sakane, N., and Nikami, H. (1996). Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic B3-adrenergic agonist. J. Clin. Invest. 97: 2898-2904.
89. Newsholme, E.A., and Randle, P.J. (1964). Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in perfused rat heart. Biochemical Journal 93: 641-651.
90. Nordfors, L., Hoffstedt, J., Nyberg, B., Thorne, A., Arner, P., Schalling, M., and Lonnqvist, F. (1998). Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects. Diabetologia 41: 935-939.
91. Oberkofler, H., Liu, Y.M., Esterbauer, H., Hell, E., Krempler, F., and Patsch, W. (1998). Uncoupling protein-2 gene: Reduced mRNA expression in intraperitoneal adipose tissue of obese humans. Diabetologia 41: 940-946.
92. Oyono-Enguelle, S., Freund, H., On, C., Gartner, M., Heitz, A., Marbach, J., Maccari, F., Frey, A., Bigot, H., and Bach, A.C. (1988). Prolonged submaximal exercise and L-carntine in humans. Eur. J. Appl. Physiol. 58: 53-61.
93. Pan, D.A., Lillioja, S., Kriketos, A.D., Milner, M.R., Baur, L.A., Bogardus, C., Jenkins, A.B., and Storlien, L.H. (1997). Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46: 983-988.
94. Park, Y., Albright, K.J., Liu, W., Storkson, J.M., Cook, M.E., and Pariza, M.W. (1997). Effect of conjugated linoleic acid on body composition in mice. Lipids 32: 853-858.
95. Park, Y., Albright, K.J., Storkson, J.M., Liu, W., Cook, M.E., and Pariza, M.W. (1999a). Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34: 243-248.
96. Park, Y., Storkson, J.M., Albright, K.J., Liu, W., and Pariza, M.W. (1999b). Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induce body composition changes in mice. Lipids 34: 235-241.
97. Parks, E.J., and Hellerstein, M.K. (2000). Carbohydrate-induced hypertriacylglycerolemia: Historical perspective and review of biological mechanisms. Am. J. Clin. Nutr. 71: 412-433.
98. Parks, E.J., Krauss, R.M., Christiansen, M.P., Neese, R.A., and Hellerstein, M.K. (1999). Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance. J. Clin. Invest. 104: 1087-1096.
99. Pasquali, R., Cesari, M.P., Melchionda, N., Stefanini, C., and Raitano, A. (1987). Does ephedrine promote weight loss in low-energy-adapted obese women? Int. J. Obesity 11: 163-168.
100. Peterson, H.R., Rothschild, M., Weinberg, C.R., Fell, R.D., McLeish, K.R., and Pfeifer, M.A. (1988). Body fat and the activity of the autonomic nervous system. N. Engl. J. Med. 318: 1077-1083.
101. Proserpi, C., Sparti, A., Schutz, Y., Di Vetta, V., Milon, H., and Jequier, E. (1997). Ad libitum intake of a high-carbohydrate or high-fat diet in young men: Effects of nutrient balances. Am. J. Clin. Nutr. 66: 539-545.
102. Randle, P.J., Hales, C.N., Garland, P.B., and Newsholme, E.A. (1963, April 13). The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. The Lancet: 785-789.
103. Randle, P.J., Newsholme, E.A., and Garland, P.B. (1964). Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochemical Journal 93: 652-665.
104. Ranneries, C., Bulow, J., Buemann, B., Christensen, N.J., Madsen, J., and Astrup, A. (1998). Fat metabolism in formerly obese women. Am. J. Physiol. (Endocrinol. Metab.) 274: E155-E161.
105. Robertson, D., Wade, D., Workman, R., and Wosley, R.L. (1981). Tolerance to the humoral and hemodynamic effects of caffeine. J. Clin. Invest. 67: 1111-1117.
106. Rudel, L.L. (1999). Invited commentary. Atherosclerosis and conjugated linoleic acid. Brit. J. Nutr. 81: 177-179.
107. Saltzman, E., Dallal, G.E., and Roberts, S.B. (1997). Effect of high-fat and low-fat diets on voluntary energy intake and substrate oxidation: Studies in identical twins consuming diets matched for energy density, fiber, and payability. Am. J. Clin. Nutr. 66: 1332-1339.
108. Santomauro, A.T.M.G., Boden, G., Sivla, M.E.R., Rocha, D.M., Santos, R.F., Ursich, M.J.M., Strassmann, P.G., and Wajchenberg, B.L. (1999). Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes 48: 1836-1841.
109. Satory, D.L., and Smith, S.B. (1999). Conjugated linoleic acid inhibis proliferation but stimulated lipid filling of murine 3T3-L1 preadipocytes. J. Nutr. 129: 92-97.
110. Scarpace, P.J., Matheny, M., Pollock, B.H., and Tumer, N. (1997). Leptin increases uncoupling protein expression and energy expenditure. Am. J. Physiol. (Endocrinol. Metab.) 273: E226-E230.
111. Schrauwen, P., Van Marken Lichtenbelt, W.D., Saris, W.H., and Westerterp, K.R. (1997a). Role of glycogen-lowering exercise in the change of fat oxidation in response to a high-fat diet. Am. J. Physiol. (Endocrinol. Metab.) 273: E623-E629.
112. Schrauwen, P., Van Marken Lichtenbelt, W.D., Saris, W.H.M., and Westerterp, K.R. (1997b). Changes in fat oxidation in response to a high-fat diet. Am. J. Clin. Nutr. 66: 276-282.
113. Schrauwen, P., Van Marken Lichtenbelt, W.D., Saris, W.H.M., and Westerterp, K.R. (1998). Fat balance in obese subjects: Role of glycogen stores. Am. J. Physiol. (Endocrinol. Metab.) 274: E1027-E1033.
114. Schrauwen, P., Walder, K., and Ravussin, E. (1999). Human uncoupling proteins and obesity. Obes. Res., 7(1): 97-105.
115. Schwarz, J.M., Neese, R.A., Turner, S., Dare, D., and Hellerstein, M.K. (1995). Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J. Clin. Invest. 96: 2735-2743.
116. Segre, G., Bianchi, E., Corsi, M., D'Iddio, S., Ghirardi, O., and Maccari, F. (1988). Plasma and urine pharmacokinetics of free and of short-chain carnitine after administration of carnitine in man. Drug Research 11: 1830-1834.
117. Shimabukuro, M., Koyama, K., Chen, G., Wang, M.Y., Trieu, F., Lee, Y., Newgard, C.B., and Unger, R.H. (1997). Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc. Natl. Acad. Sci. 94: 4637-4641.
118. Shumate, J.B., Carroll, J.E., Brooke, M.H., and Choksi, R.M. (1982). Palmitate oxidation in human muscle: Comparison to CPT and carnitine. Muscle Nerve 5: 226-231.
119. Siliprandi, N., Di Lisa, F., Pieralisi, G., Ripari, P., Maccari, F., Menabo, R., Giamberardino, M. A., and Vecchiet, L. (1990). Metabolic changes induced by maximal exercise in human subjects following L-carnitine administration. Biochim. Biophys. Acta 1034: 17-21.
120. Simoneau, J.-A., and Kelley, D.A. (1997). Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J. Appl. Physiol. 83(1): 166-171.
121. Simoneau, J.A., Kelley, D.E., Neverova, M., and Warden, C.H. (1998). Overexpression of muscle uncoupling protein 2 content in human obesity associates with reduced skeletal muscle lipid utilization. Faseb. J. 12: 1739-1745.
122. Skov, A.R., Toubro, S., Ronn, B., Holm, L., and Astrup, A. (1999). Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int. J. Obes. Relat. Metab. Disord. 23: 528-36.
123. Smith, S.R., de Jonge, L., Zachwieja, J.J., Roy, H., Nguyen, T., Rood, J.C., Windhauser, M.M., and Bray, G.A. (2000). Fat and carbohydrate balances during adaptation to a high-fat diet. Am. J. Clin. Nutr. 71: 450-457.
124. Soop, M., Bjorkman, O., Cederblad, G., Hagenfeldt, L., and Wahren, J. (1988). Influence of carnitine supplementation on muscle substrate and carnitine metabolism during exercise. J. Appl. Physiol. 64: 2394-2399.
125. Stallings, V.A., and Pencharz, P.B. (1992). The effect of a high protein-low calorie diet on the energy expenditure of obese adolescents. Eur. J. Clin. Nutr. 46: 897-902.
126. Stanko, R.T., and Adibi, S.A. (1986). Inhibition of lipid accumulation and enhancement of energy expenditure by the addition of pyruvate and dihydroxyacetone to a rat diet. Metabolism 35: 182-186.
127. Stanko, R.T., and Arch, J.E. (1996). Inhibition of regain in body weight and fat with addition of 3-carbon compounds to the diet with hyperenergetic refeeding after weight reduction. Int. J. Obes. Relat. Metab. Disord. 20: 925-930.
128. Stanko, R.T., Ferguson, T.L., Newman, C.W., and Newman, R.K. (1989). Reduction of carcass fat in swine with dietary addition of dihydroxyacetone and pyruvate. J. Anim. Sci. 67: 1272-1278.
129. Stanko, R.T., Mendelow, H., Shinozuka, H., and Adibi, S.A. (1978). Prevention of alcoholinduced fatty liver by natural metabolites and riboflavin. J. Lab. Clin. Med. 91: 228-235.
130. Stanko, R.T., Tietze, D.L., and Arch, J.E. (1992). Body composition, energy utilization, and nitrogen metabolism with a severly restricted diet supplemented with dihydroxyacetone and pyruvate. Am. J. Clin. Nutr. 55: 771-776.
131. Steinberg, G.R., and Dyck, D.J. (in press). Development of leptin resistance in rat soleus muscle in response to high-fat diets. Am. J. Physiol. Endocrinol. Metab.
132. Stone, M.H., Sanborn, K., Smith, L.L., O'Bryant, H.S., Hoke, T., Utter, A.C., Johnson, R.L., Bros, R., Hruby, J., Pierce, K.C., Stone, M.E., and Garner, B. (1999). Effects of in-season (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int. J. Sport Nutr. 9: 146-165.
133. Stubbs, R.J., Murgatroyd, P.R., Goldberg, G.R., and Prentice, A.M. (1993). Carbohydrate balance and the regulation of day-to-day food intake in humans. Am. J. Clin. Nutr. 57: 897-903.
134. Stubbs, R.J., Ritz, P., Coward, W.A., and Prentice, A.M. (1995). Covert manipulation of the ratio of dietary fat to carbohydrate and energy density: Effect on food intake and energy balance in free-living men eating ad libitum. Am. J. Clin. Nutr. 62: 330-337.
135. Sukala, W.R. (1998). Pyruvate: Beyond the marketing hype. International Journal of Sports Medicine 8: 241-249.
136. Sullivan, A.C., Hamilton, J.G., Miller, O.N., and Wheatley, V.R. (1972). Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate. Arch. Biochem. Biophys. 150: 183-190.
137. Sullivan, A.C., Triscari, J., Hamilton, J.G., Miller, O.N., and Wheatley, V.R. (1974). Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat: I. Lipogenesis. Lipids 9: 121-128.
138. Tataranni, P.A., Young, J.B., Bogardus, C., and Ravussin, E. (1997). A low sympathetic nervous system activity is associated with body weight gain and development of central adiposity in Pima Indian men. Obes. Res. 5: 341-347.
139. Taylor, W.M., and Halperin, M.L. (1973). Regulation of pyruvate dehydrogenase in muscle. Inhibition by citrate. J. Biol. Chem. 248: 6080-6083.
140. Thomas, C.D., Peters, J.C., Reed, G.W., Abumrad, N.N., Sun, M., and Hill, J.O. (1992). Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. Am. J. Clin. Nutr. 55: 934-942.
141. Torgan, C.E., Brozinick, J.T., Willems, M.E.T., and Ivy, J.L. (1990). Substrate utilization during acute exercise in obese Zucker rats. J. Appl. Physiol. 69: 1987-1991.
142. Toubro, S., Astrup, A.V., Breum, L., and Quaade, F. (1993). Safety and efficacy of long-term, treatment with ephedrine, caffeine and an ephedrine/caffeine mixture. Int. J. Obesity 17: S69-S72.
143. Trappe, S.W., Costill, D.L., Goodpaster, B., Vulovich, M.D., and Fink, W.J. (1994). The effects of L-carnitine supplementatin on performance during interval swimming. International Journal of Sports Medicine 15: 181-185.
144. Tremblay, A., Lavallee, N., Almeras, N., Allard, L., Depres, J.-P., and Bouchard, C. (1991). Nutritional determinants of the increase in energy intake associated with a high-fat diet. Am. J. Clin. Nutr. 53: 1134-1137.
145. Tremblay, A., Plourde, G., Despres, J.-P., and Bouchard, C. (1989). Impact of dietary fat content and fat oxidation on energy intake in humans. Am. J. Clin. Nutr. 49: 799-805.
146. Troiano, R.P., Flegal, K.M., Kuczmarski, R.J., Campbell, S.M., and Johnson, C.L. (1995). Overweight prevalence and trends for children and adolescents. The National Health and Nutrition Examination Surveys, 1963 to 1991. Arch. Pediatr. Adolesc. Med. 149: 1085-1091.
147. van Stratum, P., Lussenburg, R.N., van Wezel, L.A., Vergroesen, A.J., and Cremer, H.D. (1978). The effect of dietary carbohydrate: Fat ratio on energy intake by adult women. Am. J. Clin. Nutr. 31: 206-212.
148. Vazquez, J.A., Kazi, U., and Madani, N. (1995). Protein metabolism during weight reduction with very-low-energy diets: Evaluation of the independent effects of protein and carbohydrate on protein sparing. Am. J. Clin. Nutr. 62(1): 93-103.
149. Vidal-Puig, A., Rosenbaum, M., Considine, R.C., Leibel, R.L., Dohm, G.L., and Lowell, B.B. (1999). Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans. Obes. Res. 7(2): 133-40.
150. Vukovich, M.D., Costill, D.L., and Fink, W.J. (1994). Carnitine supplementation: Effect on muscle carnitine and glycogen content during exercise. Med. Sci. Sports Exerc. 26: 1122-1129.
151. Watson, J.A., Fang, M., and Lowenstein, J.M. (1969). Tricarballylate and hydroxycitrate: Substrate and inhibitor of ATP: Citrate oxaloacetate lysase. Arch. Biochem. Biophys. 35: 209-217.
152. Watson, J.A., and Lowenstein, J.M. (1970). Citrate and conversion of carbohydrate into fat. J. Biol. Chem. 245: 5993-6002.
153. West, D.B., Delany, J.P., Camet, P.M., Blohm, F., Truett, A.A., and Scimeca, J. (1998). Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. (Regulatory Integrative Comp. Physiol.) 275: R667-R672.
154. Westerterp, K.R., Verboeket-van de Venne, W.P.H.G., Westerterp-Plantenga, M.S., Velthuiste Wierik, E.J.M., de Graaf, C., and Weststrate, J.A. (1996). Dietary fat and body fat: An intervention study. Int. J. Obes. 20: 1022-1026.
155. Willett, W.C. (1998). Dietary fat and obesity: An unconvincing relation. Am. J. Clin. Nutr. 68: 1149-1150.
156. Willi, S.M., Oexmann, M.J., Wright, N.M., Collop, N.A., and Key, L.L., Jr. (1998). The effects of a high-protein, low-fat, ketogenic diet on adolescents with morbid obesity: Body composition, blood chemistries, and sleep abnormalities. Pediatrics 101(1): 61-67.
157. Worthington, B.S., and Taylor, L.E. (1974). Balanced low-calorie vs. high-protein-low-carbohydrate reducing diets. I. Weight loss, nutrient intake, and subjective evaluation. J. Am. Diet Assoc. 64(1): 47-51.
158. Yoshida, T., Sakane, N., Umekawa, T., and Kondo, M. (1994). Relationship between basal metabolic rate, thermogenic response to caffeine, and body weight loss following combined low calorie and exercise treatment in obese women. Int. J. Obesity 18: 345-350.
159. Zhou, Y., Shimabukuro, M., Koyama, K., Lee, Y., Wang, M., Trieu, F., Newgard, C.B., and Unger, R.H. (1997). Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc. Natl. Acad. Sci. USA 94: 6386-6390.