Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes

Acta Neurologica Scandinavica, Supplement

Volumn 102, Issue 176, 2000, Pages 6-11

  Yu, G ^a,b   Chen, F ^a,b   Nishimura, M ^a,b   Steiner, H ^c   Tandon, A ^a,b   Kawarai, T ^a,b   Arawaka, S ^a,b   Supala, A ^a,b   Song, Y Q ^a,b   Rogaeva, E ^a,b   Holmes, E ^a,b   Zhang, D M ^a,b   Milman, P ^a,b   Fraser, P ^a,b   Haass, C ^c   St George Hyslop, P ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

secretase; Alzheimer disease; Amyloid peptide; Presenilin complexes

Indexed keywords

ASPARTIC ACID; MEMBRANE PROTEIN; MUTANT PROTEIN; PRESENILIN 1; PRESENILIN 2; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; COMPLEMENTARY DNA; DRUG DERIVATIVE; PROTEINASE; PSEN1 PROTEIN, HUMAN; PSEN2 PROTEIN, HUMAN; SECRETASE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; KIDNEY CELL; MOLECULAR WEIGHT; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; ANIMAL; CELL MEMBRANE; CULTURE TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; PATHOPHYSIOLOGY; POINT MUTATION; PROTEIN CONFORMATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID; ASPARTIC ENDOPEPTIDASES; CELL CULTURE TECHNIQUES; CELL MEMBRANE; DNA, COMPLEMENTARY; ENDOPEPTIDASES; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MICE; POINT MUTATION; PRESENILIN-1; PRESENILIN-2; PROTEIN CONFORMATION;

EID: 0034571441     PISSN: 00651427     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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