Calmodulin, poly(ADP-ribose)polymerase and p53 are targets for modulating the effects of sulfur mustard

Journal of Applied Toxicology

Volumn 20, Issue SUPPL. 1, 2000, Pages

  Rosenthal, Dean S ^a   Simbulan Rosenthal, Cynthia M ^a   Iyer, Sudha ^a   Smith, William J ^b   Ray, Radharaman ^b   Smulson, Mark E ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Apoptosis; BAPTA; Calmodulin; Caspase 3; Differentiation; Keratinocytes; Knockout mice; p53; Poly(ADP ribose) polymerase; Sulfur mustard; W 7

Indexed keywords

CALMODULIN; DERMATOLOGICAL AGENT; MUSTARD GAS; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL DIFFERENTIATION; CULTURE TECHNIQUE; DRUG EFFECT; EPITHELIUM CELL; HUMAN; KERATINOCYTE; METABOLISM; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CALMODULIN; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; DERMATOLOGIC AGENTS; EPITHELIAL CELLS; GENES, P53; HUMANS; KERATINOCYTES; MUSTARD GAS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034570675     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1263(200012)20:1+<::aid-jat691>3.0.co;2-s     Document Type: Article

References (21)

1. Papirmeister B, Gross CL, Meier HL, Petrali JP, Johnson JB. Molecular basis for mustard-induced vesication. Fundam. Appl. Toxicol. 1985; 5: S134-49.
2. Wielckens K, Schmidt A, George E, Bredehorst R, Hilz H. DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADP-ribosyl) and poly (ADP-ribosyl) proteins. J. Biol. Chem. 1982; 257: 12872-128727.
3. Alvarez GR, Eichenberger R, Althaus FR. Poly(ADP-ribose) biosynthesis and suicidal NAD+ depletion following carcinogen exposure of mammalian cells. Biochem. Biophys. Res Commun. 1986; 138: 1051-1057.
4. Rosenthal DS, Shima TB, Celli G, De Luca LM, Smulson ME. An engineered human skin model using poly(ADP-ribose) polymerase antisense expression shows a reduced response to DNA damage. J. Invest. Dermatol. 1995; 105: 38-44.
5. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. Specific proteolytic cleavage of poly(ADP-ribose)polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 1993; 53: 3976-3985.
6. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM. Yama/CPP32b, a mammalian homolog of CED-3, is a crmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995; 81: 801-809.
7. Nicholson DW, AH A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yamin TT, Yu VL, Miller DK. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995; 376: 37-43.
8. Neamati N, Fernandez A, Wright S, Kiefer J, McConkey DJ. Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei. J. Immunol. 1995; 154: 3788-3795.
9. Rosenthal DS, Ding R, Simbulan-Rosenthal CMC, Vaillancourt JP, Nicholson DW, Smulson ME. Intact cell evidence for the early synthesis, and subsequent late apopain-mediated suppression, of poly(ADP-ribose) during apoptosis. Exp Cell Res. 1997; 232: 313-321.
10. Simbulan-Rosenthal CMC, Rosenthal DS, Iyer S, Boulares AH, Smulson ME. Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis. J. Biol. Chem. 1998; 273: 13703-13712.
11. Ray R, Majerus BJ, Munavalli GS, Petrali JP. US Army Med. Res. Biosci. Rev. 1993; 1: 267-276.
12. Ray R, Legere RH, Majerus BJ, Petrali JP. Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane. Toxicol. Appl. Pharmacol. 1995; 131: 44-52.
13. Mol MAE, Smith W. Calcium homeostasis and calcium signaling in sulfur mustard-exposed normal human epidermal keratinocytes. In Chem.-Biol. Interact. 1996; 100: 85-93.
14. Ray R, Benton BJ, Anderson DR, Byers SL, Shih ML, Petrali JP. The intracellular free calcium chelator BAPTA prevents sulfur mustard toxicity in cultured normal human epidermal keratinocytes. In Proc. Medical Defense Bioscience Research Vol. 2. US Army Medical Research Institute of Chemical Defense: Aberdeen Proving Ground, MD, 1996; 1021-1027.
15. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 1980; 19: 245-254.
16. Stanley JR, Yuspa SH. Specific epidermal protein markers are modulated during calcium-induced terminal differentiation. J. Cell Biol. 1983; 96: 1809-1814.
17. Rosenthal DS, Steinert PM, Chung S, Huff CA, Johnson J, Yuspa SH, Roop DR. A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes. Cell Growth Diff. 1991; 2: 107-113.
18. Li L, Tucker RW, Hennings H, Yuspa S. Chelation of intracellular calcium inhibits murine keratinocyte differentiation in vitro. J. Cell. Physiol. 1995; 163: 105-114.
19. Kaiser N, Edelman IS. Calcium dependence of glucocorticoid-induced lymphocytolysis. Proc. Natl. Acad. Sci. USA 1977; 74: 638-642.
20. Shiokawa D, Ohyama H, Yamada T, Takahashi K, Tanuma S. Eur. J. Biochem. 1994; 226: 23-30.
21. Takata M, Homma Y, Kurosaki T. Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis. J. Exp. Med. 1995; 182: 907-914.