Comparison of cell size in sulfur mustard-induced death of keratinocytes and lymphocytes

Journal of Applied Toxicology

Volumn 20, Issue SUPPL. 1, 2000, Pages

  Moser, Janet ^a,b   Meier, Henry L ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^b U S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND   (United States)

Author keywords

Apoptosis; Cell size; Keratinocytes; Necrosis; Sulfur mustard

Indexed keywords

DERMATOLOGICAL AGENT; MUSTARD GAS;

APOPTOSIS; ARTICLE; BIOASSAY; BIOLOGICAL MODEL; CELL SIZE; COMPARATIVE STUDY; CULTURE TECHNIQUE; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; HUMAN; KERATINOCYTE; LYMPHOCYTE; METHODOLOGY; NECROSIS; PHYSIOLOGY; TIME;

APOPTOSIS; BIOLOGICAL ASSAY; CELL CULTURE TECHNIQUES; CELL SIZE; DERMATOLOGIC AGENTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KERATINOCYTES; LYMPHOCYTES; MODELS, BIOLOGICAL; MUSTARD GAS; NECROSIS; TIME FACTORS;

EID: 0034570615     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1263(200012)20:1+<::aid-jat693>3.0.co;2-m     Document Type: Article

References (22)

1. Anslow WP, Houck CR. Systemic pharmacology and pathology of sulfur and nitrogen mustards. In Chemical Warfare Agents and Related Chemical Problems (DTIC AD245 270), National Defense Research Committee (ed.). US Office of Scientific Research and Development: Washington, DC 1946; 440-479.
2. Renshaw B. Mechanisms in production of cutaneous injuries by sulfur and nitrogen mustards. In Chemical Warfare Agents and Related Chemical Problems (DTIC AD245 270). ed. by National Defense Research Committee, pp. 470-518. U.S. Office of Scientific Research and Development, Washington, D.C. 1946.
3. Cullumbine H. Medical aspects of mustard gas poisoning. Nature 159: 151-153.
4. Fox M, Scott D. The genetic toxicology of nitrogen and sulphur mustard. Mutat. Res. 1980; 75: 131-168.
5. Papirmeister B, Gross CL, Meier HL, Petrali JP, Johnson JB. Molecular basis for mustard-induced vesication. Fundam. Appl. Toxicol. 1985; 5: S134-S149.
6. Moser J, Meier HL. The comparison of keratinocytes and lymphocytes on sulfur mustard-dependent changes in cell yield and viability. Int. J. Toxicol. 1988; 17: 1-18.
7. Smith WJ, Sanders KM, Gales YA, Gross CL Flow cytometric analysis of toxicity by vesicating agents in human cells in vitro. J. Toxicol. Cutan. Ocul. Toxicol. 1991; 10: 33-42.
8. Smith WJ, Sanders KM, Caulfield JE, Gross CL. Sulfur mustard-induced biochemical alterations in proliferating human cells in culture. J. Toxicol. Cutan. Ocul. Toxicol. 1992; 11: 293-304.
9. Meier HL, Johnson JB. The determination and prevention of cytotoxic effects induced in human lymphocytes by the alkylating agent 2,2′-dichlorodiethyl sulfide (sulfur mustard, HD). Toxicol. Appl. Pharmacol. 1992; 113: 234-239.
10. Clayson ET, Kelly SA, Meier HL. Effects of specific inhibitors of cellular functions on sulfur mustard-induced cell death. Cell Biol. Toxicol. 1993; 9: 165-175.
11. Martens ME. In vitro studies of glucose metabolism in human epidermal keratinocytes exposed to sulfur mustard. J. Am. Coll. Toxicol. 1997; 15: S19-S31.
12. + levels in human leukocytes. Toxicol. Lett. 1987; 39: 109-122.
13. Meier HL, Clayson ET, Kelly SA, Corun CM. Effect of Sulfur Mustard (HD) on ATP levels of human lymphocytes cultured in vitro. In Vitro Toxicol. 1996; 9: 135-139.
14. + levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard. Toxicol. Appl. Pharmacol. 1989; 98: 159-165.
15. Mol MAE, van de Ruit AMBC. Concentration- and time-related effects of sulphur mustard on human epidermal keratinocyte function. In Vitro Toxicol. 1992; 6: 245-251.
16. Smith WJ, Gross CL, Chan P, Meier HL. The use of human epidermal keratinocytes in culture as a model for studying the biochemical mechanisms of sulfur mustard toxicity. Cell Biol. Toxicol. 1990; 6: 285-291.
17. Martens ME, Smith WJ. Mechanisms of sulfur mustard-induced metabolic injury. In Proceedings of the 1993 Medical Defense Bioscience Review (AD/A275667). US Army Medical Research Institute of Chemical Defense: Aberdeen Proving Ground, MD, 1993; 257-263.
18. Meier HL, Millard CB. Effects of sulfur mustard on the higher order nuclear structure of human lymphocytes. In Proceedings of the 1996 Medical Defense Bioscience Review (AD/A321841). US Army Medical Research Institute of Chemical Defense: Aberdeen Proving Ground, MD, 1996; 957-966.
19. +-calmodulin and caspase-dependent pathway. J. Invest. Dermatol. 1998; 111: 101-108.
20. Clonetics Corporation. Clonetics' normal human epidermal keratinocytes. In Clonetics Corporation 1993 Normal Human Cell Systems Catalog. Clonetics: San Diego, CA, 1993; 6-7.
21. Kerr JFR, Harmon BV. Definition and incidence of apoptosis: an historical perspective. In Apoptosis, The Molecular Basis of Cell Death, Tomei LD, Cope FO (eds). Cold Spring Harbor Laboratory Press: New York, 1991; 5-29.
22. Smith CA, Wood EJ. The cell cycle and cell death. In Cell Biology (2nd edn). Smith CA, Wood EJ (eds). Chapman & Hall: New York, 1996; 495-513.