Early metabolic defects for developing diabetes mellitus among offspring of patients with type 2 diabetes are independent of gender

West Indian Medical Journal

Volumn 49, Issue 4, 2000, Pages 276-280

  Ezenwaka, C E ^a   Offiah, N V ^a   Davis G ^a  

^a UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANTHROPOMETRY; ARTICLE; FEMALE; GENETICS; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RESISTANCE; MALE; METABOLIC DISORDER; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR FAMILY; REGRESSION ANALYSIS; RISK FACTOR; SEX DIFFERENCE;

ADULT; ANTHROPOMETRY; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC DISEASES; NUCLEAR FAMILY; REGRESSION ANALYSIS; RISK FACTORS; SEX FACTORS;

EID: 0034569103     PISSN: 00433144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Olefsky JM, Kolterman OG, Scarlett, JA. Insulin action and resistance in obesity and NIDDM. Am. J. Physiol. 1982; 243: E15-30
2. DeFronzo RA, Simmonson, D, Ferrannini E. Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin dependent) and type 1 (insulin dependent) diabetes mellitus. Diabetologia 1982; 23: 313-9
3. Weir GC. Non-insulin dependent diabetes mellitus: interplay between â-cell inadequacy and insulin resistance. Am J Med 1982; 73: 461-4.
4. Reaven GM. Insulin resistance in NIDDM. Does it exist and can it be measured? Am J Med 1983; 74: 3-17.
5. Barnett AH, Effo C, Leslie RD, Pyke DA: Diabetes in identical twins: a study of 200 pairs. Diabetologia 1981; 20: 87-93.
6. Newman B, Sleby JV, King MC, Slemenda C, Fabitz P, Friedman CD: Concordance for type 2 (NIDDM) diabetes in male twins. Diabetologia 1987; 30: 763-8.
7. Osei K, Cottrell DA, Adejuwon CA, Ezenwaka CE, Akanji AO, O'Doriso TM. : Serum insulin and glucose concentrations in people at risk for type II diabetes: a comparative study of African Americans and Nigerians. Diabetes Care 1993; 16: 1367-75.
8. Ezenwaka CE, Akanji AO, Osei K, Adejuwon CA, O'Dorisio TM, Cotrell DA, et al. Glucose and insulin responses to intra-venous glucose challenge in relatives of Nigerian patients with non-insulin dependent diabetes mellitus. Diabetes Res Clin Pract 1993; 20: 175-81.
9. Eriksson JE, Franssila KA, Ekstrand CS, Widen W, Schalin C: Early metabolic defects in persons at increased risk for non-insulin dependent diabetes mellitus. N Engl J Med 1989; 320: 337-43.
10. Warram JH, Blaise CM, Andrzej S, Soelder JS, Kahn CR: Slow glucose removal rate and hyperinsulinaemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Int Med 1990; 113: 909-15.
11. Osei K. Increased basal glucose production and utilisation in non-diabetic first-degree relatives of patients with NIDDM. Diabetes 1990; 39: 597-601.
12. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK: Increased insulin concentration in non-diabetic offspring of diabetic parents. N Engl J Med 1988; 319: 1297-1301.
13. Van Haeften TW, Dubbeldam S, Zonderland ML, Erkelens DW: Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects: Assessments using hyperglycemic glucose clamp and oral glucose tolerance tests. Diabetes Care 1998; 21: 278-82.
14. Snehalatha C, Ramachandran A, Satyavani K, Latha E. Viswanathan V.: Study of genetic prediabetic South Indian subjects: importance of hyperinsulinemia and B-cell dysfunction. Diabetes Care 1998; 21: 76-9.
15. Kobberling J, Tillil H. Empirical risk figures for first degree relatives of no-insulin dependent diabetes, In: Kobberling J, Tattersall RB, eds. The Genetics of Diabetes Mellitus. London: Academic Press, 1982: 201-9.
16. Ezenwaka EC, Davis G, NV Offiah. Insulin secretion in normal glucose-tolerant offspring of patients with Type 2 diabetes in Trinidad, West Indies (In Press, Southern Medical Journal).
17. Ezenwaka EC, G Davis. Increased risk of cardiovascular disease in newly diagnosed type 2 diabetic patients in a primary health care center in Trinidad. (In Press. Diabetes Res Clin Practice J).
18. Miller GJ, Maude GH, Beckles GLA. Incidence of hypertension and non-insulin dependent diabetes mellitus and associated risk factors in a rapidly developing Caribbean community: the St James survey, Trinidad. J Epidemiol Comm Health 1996; 50: 497-504.
19. Gulliford MC. Epidemiological transition in Trinidad and Tobago, West Indies 1953-1992. Inter J Epidemiol 1996; 25: 357-65.
20. Wilks R, Rotimi C, Bennett F, McFarlane-Anderson N, Kaufman JS, Anderson SG, et al. Diabetes in the Caribbean: results of a population survey from Spanish Town, Jamaica. Diabetic Med 1999; 16: 75-883.
21. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-9.
22. Wolever TMS, Jenkins DJA, Jenkins AL, et al. The glycemic index: methodology and clinical implications. Am J Clin Nutr 1991; 54: 846-54.
23. SPSS for Windows. User's Guide, New York: McGraw-Hill, 1999.
24. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complication. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Med 1998; 15: 539-53.
25. Seltzer HS, Allen EW, Herron AL, et al. Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J Clin Invest 1967; 46: 323-35.
26. Olefsky J, Farquhar JW, Reaven GM. Relationship between fasting plasma insulin level and resistance to insulin mediated glucose uptake in normal and diabetic subjects. Diabetes 1973; 22: 507-13.
27. O'Rahilly SP, Rudensky AS, Burnett MA. Beta-cell dysfunction rather than insulin insensitivity is the primary defect in familial type 2 diabetes. Lancet 1986; 1: 360-4.
28. Valdes CT, Elkind-Hirsh KE. Intravenous glucose test-derived insulin sensitivity changes during the menstrual cycle. J Clin Endocrinol Metab 1991: 72, 642.
29. Ezenwaka EC, Akanji AO, Adejuwon CA, Abbiyesuku FM, Akinlade KS. Insulin responses following glucose administration in menstruating women. Int J Gynecol Obstet 1993; 42: 155-9.
30. DeFronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerotic vascular disease. Diabetes Care 1991; 18: 173-94.
31. Zavaroni I, Bonini L, Fantuzzi M, Dall'Aglio E, Passeri M, Reaven GM. Hyperinsulinaemia, obesity and syndrome X. J Intern Med 1994; 235: 51-6.
32. Ishikawa M, Pruneda ML, Adams-Huet B, Raskin P. Obesity-independent hyperinsulinaemia in non-diabetic first-degree relatives of individuals with type 2 diabetes. Diabetes 1998; 47: 788-892.
33. Nyholm B, Mengel A, Nielsen S, Skjaerback CB, Moller N, Alberti KG, et al. Insulin resistance among relatives of patients with NIDDM. Significance of physical fitness and muscle metabolism. Ugestkrift for Laeger 1998; 164: 410-5.
34. Fukushima M, Taniguchi A, Sakai M, Doi K, Nagasaka S, Tanaka H, et al. Homeostasis model assessment as a clinical index of insulin resistance: comparison with the minimal model analysis. Diabetes Care 1999; 22: 1911-2.
35. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000; 23: 57-63.