Symbiosis therapy: The potential of using human protozoa for molecular therapy

Molecular Therapy

Volumn 2, Issue 6, 2000, Pages 535-538

  Vaccaro, Dennis E ^a  

^a Symbiontics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRIMATES; PROTOZOA;

PROTEIN;

ANIMAL; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; PROTOZOON; REVIEW; SYMBIOSIS;

ANIMALS; GENE THERAPY; GENETIC VECTORS; HUMANS; PROTEINS; PROTOZOA; SYMBIOSIS;

EID: 0034567342     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0218     Document Type: Review

References (26)

1. Steidler, L., et al. (2000). Treatment of murine colitis by Lactococus lactis secreting interleukin-10. Science 289: 1352-1355.
2. Cox, F. E. G. (1993). Parasitic protozoa. In Modern Parasitology (F. E. G. Cox, Ed.), pp. 1-23. Blackwell Scientific, Oxford.
3. Chemin, E. (1984). The malariatherapy of neurosyphilis. J. Parasitol. 70: 611-617.
4. Buckner, F. S., Verlinde, C. L., La Flemme, A. C., and Van Voorhis, W. C. (1996). Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing β-galactosidase. Antimicrob. Agents Chemother. 40: 2592-2597.
5. LeBowitz, J. H., Coburn, C. M., and Beverley, S. M. (1991). Simultaneous transient expression assays of the trypanosomatid parasite Leishmania using β-galactosidase and β-glucuronidase as reporter enzymes. Gene 103: 119-123.
6. Lee, M. G.-S., and Van der Ploeg, L. H. T. (1990). Homologous recombination and stable transfection in the parasitic protozoan Trypanosoma brucei. Science 250: 1583-1587.
7. ten Asbroek, A. L., Ouellette, M., and Borst, P. (1990). Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brusei. Nature 348: 174-175.
8. Laban, A., and Wirth, D. (1989). Transfection of Leishmania enriettii and expression of chloramphenicol acetyltransferase gene. Proc. Natl. Acad. Sci. USA 86: 9119-9123.
9. Goonewardene, R., et al. (1993). Transfection of the malaria parasite and expression of firefly luciferase. Proc. Natl. Acad. Sci. USA 90: 5234-5236.
10. Hug, M., Carruthers, V. B., Hartmann, C., Sherman, D. S., Cross, G. A. M., and Clayton, C. (1993). A possible role for the 3′-untranslated region in developmental regulation in Trypanosoma brucei. Mol. Biochem. Parasitol. 61: 87-96.
11. Ha, D. S., Schwarz, J. K., Turco, S. J., and Beverley, S. M. (1996). Use of the green fluorescent protein as a marker in transfected Leishmania. Mol. Biochem. Parasitol. 77: 57-64.
12. Striepen, B., He, C. Y., Matrajt, M., Soldati, D., and Roos, D. S. (1998). Expression, selection, and organellar targeting of the green fluorescent protein in Toxoplasma gondii. Mol. Biochem. Parasitol. 92: 325-338.
13. VanWye, J. D., and Haldar, K. (1997). Expression of green fluorescent protein in Plasmodium falciparum. Mol. Biochem. Parasitol. 87: 225-229.
14. Tobin, J. F., and Wirth, D. F. (1993). Mutational analysis of a signal sequence required for protein secretion in Leishmania major. Mol. Biochem. Parasitol. 62: 243-249.
15. LeBowitz, J. H., Coburn, C. M., McMahon-Pratt, D., and Beverley, S. M. (1990). Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes. Proc. Natl. Acad. Sci. USA 87: 9736-9740.
16. Lippert, D. N., Dwyer, D. W., Li, F., and Olafson, R. W. (1999). Phosphoglycosylation of a secreted acid phosphatase from Leishmania donovani. Glycobiology 9: 627-636.
17. Zamze, S. (1991). Glycosylation in parasitic protozoa of the trypanosomatidae family. Glycoconj. J. 8: 443-447.
18. Hager, K. M., Striepen, B., Tilney, L. G., and Roos, D. S. (1999). The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii. J. Cell Sci. 112: 2631-2638.
19. Zimmer, C. (2000). Parasites make scaredy-rats foolhardy. Science 289: 525-527.
20. Marzochi, K. B., et al. (1998). Phase I study of an inactivated vaccine against American tegumentary Leishmaniasis in normal volunteers in Brazil. Mem. Inst. Oswaldo Cruz 93: 205-212.
21. Titus, R. G., Gueiros-Filho, de Freitas, L. A. R., and Beverley, S. M. (1995). Development of a safe live Leishmania vaccine line by gene replacement. Proc. Natl. Acad. Sci. USA 92: 10267-10271.
22. Gueiros-Filho, F. J., and Beverley, S. M. (1994). On the introduction of genetically modified Leishmania outside the laboratory. Exp. Parasitol. 78: 425-428.
23. Grimaldi, G., Jr., et al. (1998). Vaccination with a genetically attenuated Leishmania vaccine line against cutaneous Leishmaniasis in the Asian rhesus macaques. XIVth Annual Meeting of the Brazilian Society of Protozoology, Caxambu, Brazil.
24. Ghedin, E., Charest, H., Zhang, W. W., Debrabant, A., Dwyer, D., and Matlashewski, G. (1998). Inducible expression of suicide genes in Leishmania donovani amastigotes. J. Biol. Chem. 273: 22997-22303.
25. Aebischer, T. (1994). Recurrent cutaneous Leishmaniasis: A role for persistent parasites? Parasitol. Today 10: 25-28.
26. Meikle, P. J., Hopwood, J. J., Clague, A. E., and Carey, W. F. (1999). Prevalence of lysosomal storage disorders. JAMA 281: 249-254.