Coamplification of 3-hydroxy-3-methylglutaryl coenzyme A reductase genes in methotrexate-resistant human leukemia cell lines

Oncology Research

Volumn 12, Issue 1, 2000, Pages 11-15

  Srimatkandada, Srinivasan ^a   Dube, Shyam K ^b   Carmen, Mark ^a   Bertino, Joseph R ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Coamplification; Dihydrofolate reductase; Methotrexate; Myclocytic leukemia cell lines

Indexed keywords

DIHYDROFOLATE REDUCTASE; DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; METHOTREXATE;

ARTICLE; CELL CULTURE; CELL STRAIN HL 60; CELL STRAIN K 562; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; GENE AMPLIFICATION; GENETICS; HUMAN; LEUKEMIA; METABOLISM; NORTHERN BLOTTING; SOUTHERN BLOTTING;

BLOTTING, NORTHERN; BLOTTING, SOUTHERN; DNA; DRUG RESISTANCE; GENE AMPLIFICATION; HL-60 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; K562 CELLS; LEUKEMIA; METHOTREXATE; RNA, MESSENGER; TETRAHYDROFOLATE DEHYDROGENASE; TUMOR CELLS, CULTURED;

EID: 0034567288     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000001108747390     Document Type: Article

References (36)

1. Schimke, R. T. Gene amplification in cultured mammalian cells. Cell 37:705-713; 1984.
2. Dube, S. K.; Bertino, J. R. Gene amplification. In: Dulbecco, R., ed. Encyclopedia of human biology, vol. 3. San Diego: Academic Press; 1991:785-789.
3. Kellems, R. E., ed. Gene amplification in mammalian cells. New York: Marcel Dekker; 1992.
4. Stark, G. R. Regulation and mechanisms of mammalian gene amplification. In: Vande Woude, G. F.; Klein, G., eds. Advances in cancer research, vol. 61. San Diego: Academic Press; 1993:87-113.
5. Di Leonardo, A.; Linke, S. P.; Yin, Y.; Wahl, G. M. Cell cycle regulation of gene amplification. Cold Spring Harbor Symp. Quant. Biol. 58:655-667; 1993.
6. Hamlin, J. L. Drug resistance: DNA sequence amplification. In: Bertino, J. R., ed. Encyclopedia of cancer, vol. 1. San Diego: Academic Press; 1997:571-586.
7. Biedler, J. L.; Spengler, B. A. Cytogenetic consequences of gene amplification: HSRs and DMs in antifolate-resistant and multi-drug-resistant Chinese hamster and mouse cells and human neuroblastoma cells with amplified N-myc protooncogenes. In: Kellems, R. E., ed. Gene amplification in mammalian cells. New York: Marcel Dekker; 1993:29-42.
8. Milbrandt, J. D.; Heintz, N. H.; White, W. C.; Rothman, S. M.; Hamlin, J. L. Methotrxate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene. Proc. Natl. Acad. Sci. USA 78:6043-6047; 1981.
9. Hamlin, J. L.; Chi, M. The mammalian dihydrofolate reductase locus. Biochim. Biophys. Acta 1087:107-125; 1990.
10. Giulotto, E; Saito, I.; Stark. G. R. Structure of DNA formed in the first step of CAD gene amplification. EMBO J. 5:2115-2121; 1986.
11. Srimatkandada, S.; Medina, W. D.; Cashmore, A. R.; Whyte, W.; Engel, D.; Moroson, B. A.; Franco, C. T.; Dube, S. K.; Bertino, J. R. Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate. Biochemistry 22:5774-5781; 1983.
12. Mehlman, L. A. MD thesis, Yale University School of Medicine, New Haven; 1985.
13. Funanage, B. L.; Myoda, T. T.; Moses, P. A.; Cowell, H. R. Assignment of the human dihydrofolate reductase gene to the q11 - q22 region of chromosome 5. Mol. Cell. Biol. 4:2010-2016; 1984.
14. Mohandas, T.; Heinzman, C.; Sparks, R. S.; Wasmuth, J.; Edwards, P.; Lusis, A. J. Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13 - q23 region of chromosome 5. Somat. Cell Mol. Genet. 12:89-94; 1986.
15. Huebner, K.; Isobe. M.; Croce, C. M.; Golde, D. W.; Kaufman, S. E.; Gasson, J. C. The human gene encoding GMCSF is at 5q21 - q32, the chromosome region deleted in the 5q-anomaly. Science 230:1282-1285; 1985.
16. Groffen, J.; Heisterkamp, N.; Spurr, N.; Dana, S.; Wasmuth, J. J.; Stephenson, J. R. Chromosomal localization of the human c-fms oncogene. Nucleic Acids Res. 11:6331-6339; 1983.
17. Lozzio, C. B.; Lozzio, B. B. Cytotoxicity of a factor isolated from human spleen. J. Natl. Cancer Inst. 50:535-538; 1973.
18. Blin, N. N.; Stafford, D. W. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3:2303-2306; 1976.
19. Sambrook, J.; Fritsch, E. F.; Maniatis, T. Molecular cloning: A laboratory manual, 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 1989.
20. Wahl, G. M.; Stern, M.; Stark, G. R. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc. Natl. Acad. Sci. USA 76:3683-3687; 1979.
21. Lusky, K. L.; Stevens, B. Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Biol. Chem. 260:10271-10277; 1985.
22. Chirgwin, J. M.; Przybyla, A. E.; MacDonald, R. J.; Rutter, W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299; 1979.
23. Aviv, H.; Leder, P. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc. Natl. Acad. Sci. USA 69:1408-1412; 1972.
24. Lusky, K. L.; Faust, J. R.; Chin, D. J.; Brown, M. S.; Goldstein, J. L. Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells. J. Biol. Chem. 258:8462-8469; 1983.
25. Forman, P. K.; Hamlin, J. L. Identification and characterization of a gene that is co-amplified with dihydrofolate reductase in a methotrexate resistant cell line. Mol. Cell. Biol. 9:1137-1147; 1989.
26. Kempe, T. D.; Swyryd, E. A.; Bruist, M.; Stark, G. R. Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis. Cell 9:541-550; 1976.
27. Wahl, G. M.; Padgett, R. A.; Stark, G. R. Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonoacetyl)-L-aspartate-resistant hamster cells. J. Biol. Chem. 254:8679-8689; 1979.
28. Wahl, G. M.; Vitto, L.; Rubinitz, J. Co-amplification of rRNA genes with CAD genes in N-(phosphonoacetyl)-L-aspartate-resistant Syrian hamster cell. Mol. Cell Biol. 31:2066-2075; 1983.
29. Van der Bliek, A. M.; Van der Velde-koerts; Ling, V.; Borst, P. Overexpression and amplification of five genes in a multidrugresistant Chinese hamster ovary cell line. Mol. Cell. Biol. 6:1671-1678; 1986.
30. Debatisse, M. M.; St. Vincent, R.; Buttin, G. Expression of several amplified genes in an adenylate-deaminase overproducing variant of Chinese hamster fibroblasts. EMBO J. 3:3123-3127; 1984.
31. Hurta, R. A. R.; Wright, J. A. Mammalian drug resistant mutant with multiple gene amplifications: Genes encoding the M1 component of ribonucleotide reductase, the M2 component of ribonucleotide reductase, ornithine decarboxylase, p5-8, the H-subunit of ferritin and the L-subunit of ferritin. Biochim. Biophys. Acta 1087:165-172; 1990.
32. Spradling, A. C. The organization and amplification for two chromosomal domains containing Drosophila chorion genes. Cell 27: 193-201; 1981.
33. Roberts, J. M.; Buck, L. B.; Axel, R. A structure for amplified DNA. Cell 33:53-63; 1983.
34. Shiloh, Y.; Korf, B.; Kohl, N. E.; Sakai, K.; Brodeur, G. M.; Harris, P.; Kanda, N.; Seeger, R. C.; Alt, F.; Latt, S. A. Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas. Cancer Res. 46:5297-5301; 1986.
35. Goldstein, J. L.; Brown, M. S. Regulation of the mevalonate pathway. Nature 343:425-430; 1990.
36. Chakrabarti, R.; Engleman, E. G. Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. J. Biol. Chem. 266:12216-12222; 1991.