Exogenous Lactate Sustains Synaptic Activity and Neuronal Viability, but Fails to Induce Long Term Potentiation (LTP)

Japanese Journal of Geriatrics

Volumn 37, Issue 12, 2000, Pages 962-965

  Sakurai, Takashi ^a   Yang, Bo ^a   Takata, Toshihiro ^a   Yokono, Koichi ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

Cell viability; Glucose; Lactate; Long term potentiation; Synaptic activity

Indexed keywords

GLUCOSE; LACTIC ACID;

ANIMAL; ARTICLE; CELL SURVIVAL; ENERGY METABOLISM; GUINEA PIG; HIPPOCAMPUS; LONG TERM POTENTIATION; METABOLISM; PHYSIOLOGY; SYNAPSE;

ANIMALS; CELL SURVIVAL; ENERGY METABOLISM; GLUCOSE; GUINEA PIGS; HIPPOCAMPUS; LACTIC ACID; LONG-TERM POTENTIATION; SYNAPSES;

EID: 0034565652     PISSN: 03009173     EISSN: None     Source Type: Journal    
DOI: 10.3143/geriatrics.37.962     Document Type: Article

References (4)

1. Hoyer S, Oesterreich K, Wagner O: Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type? J Neurol 1988; 235: 143–148.
2. Noraberg J, Kristensen BW, Zimmer J: Markers for neuronal degeneration in organotypic slice cultures. Brain Res Protocol 1999; 3: 278–290.
3. Bigl M, Bruckner MK, Arendt T, Bigl V, Eschrich K: Activities of key glycolytic enzymes in the brain of patients with Alzheimer' disease. J Neural Transm 1999; 106: 499–511.
4. Craft S, Newcomer J, Kanne S, Dagogo-Jack S, Cryer P, Sheline Y, et al.: Memory improvement following induced hyperinsulinemia in Alzheimer' disease. Neuro-biolgy of Aging 1996; 17: 123–130.