Irinotecan in esophageal cancer

ONCOLOGY

Volumn 14, Issue 12 SUPPL. 14, 2000, Pages 26-30

  Enzinger, Peter C ^c   Ilson, David H ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CISPLATIN; DNA TOPOISOMERASE; DRUG DERIVATIVE; ENZYME INHIBITOR; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; PACLITAXEL;

ADULT; AGED; CLINICAL TRIAL; DRUG ANTAGONISM; ESOPHAGUS TUMOR; FEMALE; HUMAN; MALE; MIDDLE AGED; PHASE 2 CLINICAL TRIAL; REVIEW;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; CISPLATIN; CLINICAL TRIALS; CLINICAL TRIALS, PHASE II; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; ESOPHAGEAL NEOPLASMS; FEMALE; FLUOROURACIL; HUMANS; LEUCOVORIN; MALE; MIDDLE AGED; PACLITAXEL;

EID: 0034565292     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Greenlee RT, Murray T, Bolden S, et al: Cancer statistics, 2000. CA Cancer J Clin 50:7-33, 2000.
2. Müller JM, Erasmi H, Stelzner M, et al: Surgical therapy of oesophageal carcinoma. Br J Surg 77:845-857, 1990.
3. Earlham R, Cunha-Melo JR: Ocsophageal squamous cell carcinoma: II. A critical review of radiotherapy. Br J Surg 67:457-461, 1980.
4. Al-Sarraf M, Martz K, Herskovic A, et al: Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: An intergroup study. J Clin Oncol 15:277-284, 1997.
5. Bosset JF, Gignoux M, Triboulet JP, et al: Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med 337:161-167, 1997.
6. Chen AY, Liu LF: DNA topoisomerases: Essential enzymes and lethal targets. Anna Rev Pharmacol Toxicol 34:191-218, 1994.
7. Hsiang YH, Hertzberg R, Hecht S, et al: Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 260:14873-14878, 1985.
8. Hsiang YH, Liu LF: Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res 48:1722-1726, 1988.
9. Ikeda K, Terashima M, Yaegashi Y, et al: Antitumor activities of camptothecin analogs against human esophageal cancer (abstract). Proc Am Assoc Cancer Res 36:2702, 1995.
10. Hecht JR, Parson M, Rosen LS: A phase II trial of irinotecan (CPT-11) in patients with adenocarcinoma of the esophagus and gastric cardia (abstract). Proc Am Soc Clin Oncol 18:1100, 1999.
11. Enzinger PC, Kulke MH, Clark JW, et al: Phase II trial of CPT-11 in previously untreated patients with advanced adenocarcinoma of the esophagus and stomach (abstract). Proc Am Soc Clin Oncol 19:315a, 2000.
12. Lin L, Hecht JR: A phase II trial of irinotecan in patients with advanced adenocarcinoma of the gastroesophageal (GE) junction (abstract). Proc Am Soc Clin Oncol 19:289a, 2000.