Lesiones intraepiteliales de cuello uterino Marcadores bioquímicos y virus de papiloma humano

Acta Bioquimica Clinica Latinoamericana

Volumn 34, Issue 2, 2000, Pages 183-208

  Palaoro, Luis Alberto ^a   Blanco, Ana María ^a  

^a NONE

Author keywords

Carcinoembrionic antigen; Cervical intraepithelial neoplasia; Glucose 6 phosphate dehydrogenase; Human Papillomavirus

Indexed keywords

EID: 0034562077     PISSN: 03252957     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (121)

1. BURGARDTH, E. and OSTOR, A., "Site and origin of squamous cervical cancer: a histomorphologic study", Obstet. Gynecol., 62, 117-127, 1983.
2. PAPANICOLAOU, G.N., "Survery of actualities and potencialities of exfoliative cytology in cancer diagnosis", Ann. Intern. Med., 31, 661-674, 1949.
3. REAGAN, J.W.; SEIDEMANN, J.L. and SIRACUSA, Y., "Cellular morphology of carcinoma in situ and dysplasia or atypical hiperplasia of uterine cervix", Cancer, 6, 224-235, 1953.
4. International Committee on Histological Definitions (Editorial), Acta Cytol., 6, 235-236, 1962.
5. RICHART, R.M. and BARRON, B.A., "A follow-up study of patients with cervical dysplasia", Am. J. Obstet. Gynecol., 105, 386-393, 1969.
6. STERN, E. and NEELY, P.M., "Carcinoma and Dysplasia of the cervix: a comparison of rates for new and returning populations", Acta Cytol., 7, 357-361, 1963.
7. KOTTMEIER, H., "Evolution et Traitement des epitheliomas", Rev. Franc. Gynecol., 56, 821-826, 1971.
8. NASIELL, K.; NASIELL, M. and VACLAVINKOVA, A., "Behavior of moderate cervical dysplasia during long-term follow-up", Obstet. Gynecol., 61, 609-614, 1983.
9. The 1988 Bethesda System for reporting cervical/vaginal cytologic diagnoses. Developed and approved at the National Cancer Institute, Workshop, Bethesda, Maryland, USA, December 12-13, 1988.
10. HOLMQUIST, N.D.; MCMAHAN, C.A. and WILLIAMS, O.D., "Variability in clasification of carcinoma in situ of the uterine cervix", Arch. Pathol., 84, 334-345, 1967.
11. OLD, J.W.; WIELENGA, G. and VON HAAM, E., "Squamous carcinoma in situ of the uterine cervix. Classification and histogenesis", Cancer, 18, 1589-1611, 1965.
12. VARGA, A., "The relationship of cervical dysplasia to in situ and invasive carcinoma of the cervix", Am. J. Obstet. Gynecol., 95, 759-762, 1966.
13. KOSS, L.G., "Concept of genesis and development of carcinoma of the cervix", Obstet. Gynecol. Survery, 24, 850-860, 1970.
14. CESTANO-ALMENDRAL, A.; MULLER, H. and NAUJOKS, H., "Tipographical and histological localisation of dysplasia, carcinoma in situ, microinvasions and microcarcinomata", Gynecol. Oncol., 1, 320-328, 1973.
15. JONES, H.W.; DAVIS, H.J.; PARK, I.J.; SALIMI, R.; TSENG, P.Y. and WOODRUFF, Y., "The value of the assay of chromosomes in the diagnosis of cervical neoplasia", Amer. J. Obstet. Gynecol., 102, 624-639, 1968.
16. FU, Y.S.; REAGAN, J.W.; RICHART, R.M. and TOWSEND, D.E., "Nuclear DNA and histologic studies of genital lesions in DBS-exposed progeny. Intraepithelial squamous abnormalities", Am. J. Clin. Pathol., 72, 502-514, 1979.
17. FU, Y.S.; REAGAN, J.W. and RICHART, R.M., "Definition of precursors", Gynecol. Oncol., 12, S 220-231, 1981.
18. VOGESTEIN, B. and KINZLER, K.W., "The multistep neture of cancer", Trends Genet., 9, 138-141, 1993.
19. FUJU, T.; CRUM, C.P.; WINKLER, B.; FU, Y.S. and RICHART, R.M., "Human papillomavirus infection and cervical intraepithelial neoplasia: Histopathology and DNA content", Obstet. Gynecol., 63, 99-104, 1984.
20. FROST, J.K., The Cell in Health and Disease. In Monographs in Clinical Cytology. 2da. ed. Karger AG Ed., Basilea, Suiza, 1986.
21. HERLAN, G.; GRESE, G. and WUNDERLICH, F., "In vitro ribosomal ribonucleoprotein transport upon nuclear expresion, Biochem, 19, 3960-3966, 1980.
22. SKEGG, D.C.; CORWIN, D.A.; PAUL, C. and DOLL, R., "Importance of the male factor in cancer or the cervix", Cancer Res., 2, 581-583, 1982.
23. ZUR HAUSEN, H., "Herpes simplex virus in human genital cancer", Int. Rev. Exp. Pathol., 25, 307-326, 1983.
24. CIUFFO, G., "Innesto positivo con filtrato di verruga vulgare", G. Ital. Mal. Venereal, 48, 12-17, 1907.
25. ORIEL, J.D. and ALMEIDA, J.D., "Demonstration of virus particles in human genital warts", Br. J. Vener. Dis., 46, 37-42, 1970.
26. KOSS, L.G. and DURFEE, G.R., "Unusual patterns of squamous epithelium of the uterine cervix: cytologic and pathologic study of koilocytotic atypia", Ann. NY Acad. Sci., 63, 1245-1261, 1956.
27. AYRE, J.E., An Atlas of Cervical Cytology, Abbott Laboratories, North Chicago, Illinois, 22-25, 1948.
28. PAPANICOLAOU, G., Atlas of exfoliative cytology. Harvard University Press, Cambridge, Mass, 1963.
29. MEISSELS, A., "Condylomatous lesions of the cervix and vagina. I. Cytologic patterns", Acta Cytol., 20, 505-509, 1976.
30. HILLS, E. and LAVERTY, C.R., "Electron microscopic detection of papillomavirus particles in selected koilocytotic cells in a routine cervical smear", Acta Cytol., 23, 53-56, 1979.
31. ZUR HAUSEN, "Human papillomavirus and their possible rol in squamous cell carcinomas", Curr. Top. Microbiol. Immunol., 78, 1-30, 1977.
32. TOSI, P.; PALLINI, V.; CINTORINO, M.; BUGNONI, A.; PETRACCA, R.; SYGJANEN, S.; DEL VECCHIO, M.T.; MANTYJARVI, R.; RUGGIERO, P.; ARMELLINI, D.; CHANG, F. and SYRJANEN, K., "Use of antibodies against a syntethic peptide of the E6 protein of humanpapillomavirus (HPV) type 16 for the diagnosis of genital lesions", Cytopathology, 4, 3-15, 1993.
33. DURST, M.; KLEINHEINZ, A.; HOTZ, M. and GISSMAN, L., "The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors", J. Gen. Virol., 66, 1515-1522, 1985.
34. YOSHIKAWA, H., "virological studies on generation of cervical carcinomas", Acta Obstet. Gynecol. Jpn., 42, 834-843, 1990.
35. POPESCU, N.C. and Dipaolo, J.A., "Integration of human papillomavirus 16 DNA and genomic rearrangements in inmortalized human keratinocytes lines", Cancer Res., 50, 1316-1323, 1990.
36. YEE, C.; KRISHMAN-HEWLATT, Y.; BAKER, C.C.; SCHLEGEL, R. and HOWLEY, P.M., "Presence and expresion of papillomavirus sequences in human cervical carcinoma cell lines". Am. J. Pathol., 119, 361-366, 1985.
37. th de. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1990.
38. DE VILLIERS, E., "Heterogeneity of human papillomavirus group", J. Virol., 63, 4898-4903, 1989.
39. LORINCZ, A.T.; QUIN, A.P.; GOLDSBROUGH, M.D.; SCHMIDT, B.J. and TEMPLE, G.F., "Cloning and partial DNA sequencing of two new human papillomavirus types associated wuth condyloma and low-grade cervical neoplasia", J. Virol., 63, 2829-2834, 1989.
40. LEHN, H.; VILLA, L.; MARZIONA, F.; HILGARTH, M.; HILLEMANS, H.G. and SABER, G., "Physical state and Biological activity of human papillomavirus genomes in precancerous lesions of the female genital tract", J. Gen. Virol., 69, 187-196, 1988.
41. RICHART, R.M., "Causes and management of cervical intraepithelial neoplasia". Cancer, 60, 1951-1959, 1987.
42. CULLEN, A.P.; REID, R.; CAMPION, M. and LORINCZ, A.T., "Analysis of the physical state of differents HPVDNAs in intraepithelial and invasive cervical neoplasias", J. Virol., 105, 606-612.
43. YAMAKAWA, Y.; FUKUSHIMA, M.; SHIMANO, S.; NISHIKAWA, A.; HASHIMOTO, M.; SAWADA, Y. and FUJINAKA, K., "The physical state of human papillomavirus type 16 DNA in cervical intraepithelial neoplasia", Papillomavirus Workshop, Heidelberg, Kongreshaus (Stadthalle), mayo 12 a 17, 1990.
44. MEISELS, A.; BROCHU-LAMPSON, L.; CASAS-CORDERO, M.; FORTIER, M.; MASTEL-LAFLAMME, S.; MORIN, C. and ROY, M., "Condylomata of the uterine cervix: a human papillomavirus infection" Tutorials of Cytology, Chicago, Illinois, 1981.
45. OKAGART, T.; CLARK, B.A.; BROOKER, D.C. and WILLIAMS, P.P., "Koilocytosis in dysplastic and reactive cervical squamous epithelium: An ultrastructural study", Acta Cytol., 22, 95-98, 1978.
46. REID, R.; CRUM, C.P.; HERSCHMAN, B.R.; FU, Y.S.; BRAUN, L.; SHAH, K.V.; AGRONOW, S.J. and STANHOPE, R., "Genital warts and cervical cancer III. Subclinical papillomaviral infection and cervical neoplasia are linked by a spectrum of continuous morphologic and biologic changes", Cancer, 53, 943-953, 1984.
47. KALIFAT, R., "Ultrastructural study of cervical condylomata", IX International Congress of Cytology, Bruselas, mayo 26-29, 1986.
48. RECHER, L., "Scanning electron microscopy of koilocytotic atypia" (Letters to the Editor), Acta Cytol., 28, 516-517, 1984.
49. BORAS, V.F. and DUGGAN, M.A., "Cervical dyskeratotic cells as predictors of condylomatous changes on biopsy", Acta Cytol., 33, 223-227, 1989.
50. PALAORO, L.A.; SZULC, M.; GIONGRANDE, J.C. and BARIANDARIAN, P., "Cells with Dyskeratotic inclusions in smears from cervix uteri infected by Human Papillomavirus", Brazilian Journal of Oncology, 45, N° 2 (en prensa).
51. FRANQUEMONT, D.W.; WARD, B.E.; ANDEREN, W.A. and CRUM, C.P., "Prediction of 'high risk' cervical papillomavirus infection by biopsy morphology", Am. J. Clin. Pathol., 92, 577-582, 1989.
52. MEISELS, A.; ROY, M.; FORTIER, M.; MORIN, C.; CASAS-CORDERO, M.; SHAH, K.V. and TURGEON, H., "Human papillomavirus infection of the cervix: the atypical condyloma", Acta Cytol., 25, 7-16, 1981.
53. ROWSON, K.E.K. and MAHY, B.W.J., "Human papova (warts) virus", Bacteriol Rev., 31, 110-131, 1967.
54. ARENDS, M.J.; WYLLIE, A.H. and BIRD, C.C., "Papillomaviruses and human cancer", Human Pathol, 21, 686-697, 1990.
55. DURST, M.; GLITZ, D.; SCHNEIDER, A. and ZUR HAUSEN, H., "Human papillomavirus Type 16 (HPV 16) gene expression in cervical neoplasia: analisis by in situ hybridization", Virology, 189, 132-140, 1992.
56. CHEN, S.L. and MOUNTS, P., "Transforming activity of E5A protein of human papillomavirus Type 6", Papillomavirus Workshop, Heidelberg, Kongreshaus, mayo 12 a 17, 1990.
57. CHIN, M.T.; HIROCHIKA, R.; HIROCHIKA, H.; BROKER, T.R. and CHOW, L.T., "Regulation of human papillomavirus type 11 enhancer and E6 promoter by activating and represing proteins from the E2 open reading frame: functional and biochemical studies", J. Virol., 62, 2994-3002, 1988.
58. SEDMAN, S.A.; BARBOSA, M.S.; LOWY, D.R. and SCHILLER, J.T., "Functional analysis of HPV 16 E6 Proteins, Papillomavirus Workshop, Heidelberg, Kongreshaus, mayo 12-17, 1990.
59. FERENCZY, A., "Epidemiology and clinical pathophysiology of condylomata acuminata", Am. J. Obstet. Gynecol., 172, 1331-1368, 1995.
60. PALAORO, L.A. y BLANCO, A.M., "Investigación de proteínas de cápside de papilomavirus en células exfoliadas de cuello uterino", Acta Bioq. Clín. Latin., XXVI, 409-413, 1992.
61. MUNGER, K.; PHELPS, W.C.; BUBB, V.; HOWLEY, P.M. and SCHLEGEL, R., "The E6 y E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes", J. Virol., 64, 519-526, 1990.
62. STOLER, M.H.; RHODES, C.R.; WHITBECK, A.; WOLINSKY, S.M.; CHOW, L.T. and BROKER, T.R., "Human papillomavirus type 16 and 18 gene expression in cervical neoplasia", Human Pathol., 23, 117-128, 1992.
63. BOSHART, M. and ZUR HAUSEN, H., "Human papillomaviruses in Buschke Lowenstein tumors: physical state of the DNA and identification of a tandem duplication in the non-coding region of a human papillomavirus 6 subtype", J. Virol., 5, 963-966, 1986.
64. LEHN, H.; VILLA, L.; MARZIONA, F.; HILGARTH, M.; HILLEMANS, H.G. and SAUER, G., "Physical state and biological activity of human female genital tract", J. Gen. Virol., 69, 187-196, 1988.
65. ZUR HAUSEN, H., "Disrupted dichotomous intracellular control of human papilomavirus infection in cancer of the cervix", Lancet, 343, 955-957, 1994.
66. ROSL, F.; DURST, M. and ZUR HAUSEN, H., "Selective suppression of human papillomavirus transcripts in non-tumorigenic cells by 5-azacytidin", EMBO, J 7, 1321-1328, 1988.
67. BARTON, S.E.; HOLLINGWORTH, A.; MADDOX, P.H.; EDWARDS, R.; CUZICK, J.; MC CANCE, D.J.; JENKINS, D. and SINGER, A., "Possible cofactors in the etiology of cervical intraepithelial neoplasia. An immunopathologic study", J. Reprod. Med., 34, 613-616, 1989.
68. MC CANCE, D.J.; KOPAN, R.; FUCHS, E and LAIMINS, L.A., "Human papilloma virus type 16 alters epithelial cells differentiation in vitro", Proc. Natl. Acad. Sci. USA, 85, 7169-7173, 1988.
69. DURST, M.; CROCE, C.M.; GISSMANN, L.; SCHWARTZ, E. and HUABNER, K., "Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas", Proc. Natl. Acad. Sci. USA, 84, 1070-1074, 1987.
70. MITTAL, R.; TSUTSUMI, K.; PATER, A. and PATER, M.M., "Human papillomavirus type 16 expression in cervical keratinocytes: Role of progesterone and glucocorticoide hormones", Obstet. Gynecol., 81, 5-12, 1993.
71. PATER, A; BAYATPOUR, M. and PATER, M.M., "Oncogenic transformation by human papillomavirus type 16 deoxyribonuclei acid in the presence of progesterone or progestins from oral contraceptives", Am. J. Obstet. Gynecol., 162, 1099-1113, 1990.
72. CIOCCA, D.R.; LOCASTRO, G.; ALONIO, L.V.; COBO, M.F.; LOFTI, H. and TAYSSIE, A., "Effect of human papillomavirus infection on estrogen receptor and heat shock protein hsp27 phenotype in human cervix and vagina", Int. J. Gynecol. Pathol., 11, 113-121, 1992.
73. BLESSING, M.; ZENTGRAF, H. and JORCANO, J.L., "Differentially expressed bovine cytokeratine genes. Analysis of gene link age and evolutionary conservation of 5-upstream sequences", EMBO, J 6, 567-575, 1987.
74. LEVINE, A.J. and MOMAND, J., "Tumor suppresor genes: the p53 and retinoblastoma sensitivity genes and gene products", Biochem. Biophys. Acta, 1032, 119-136, 1990.
75. DOWELL, S.P. and HALL, P.A., "The clinical relevance of the p53 tumor suppresor gene", Cytopathol., 5, 133-145, 1994.
76. FISCHMAN, W.H.; MITCHELL, G.W.; BORGES, P.R.F.; LADUR, K.T. and HAYASKY, M., "Enzymomorphology of cancer of the cervix", Cancer, 16, 118-125, 1963.
77. WILLIGHAGEN, R.G.J. and THIERY, M., "Enzyme dedifferentiation in experimentally-induced carcinoma of the uterine cervix", Acta Cytol., 10, 93-98, 1966.
78. AYRE, H.A. and GOLDENBERG, D.M., "Enzymes of the human cervix uteri. Comparison of dehydrogenases of lactate, isocitrate and phosphoglucolate in malignant and non-malignant tissue", Br. J. Cancer, 20, 743-752, 1966.
79. ROSA, G.C., "Oxidative enzymes in human vaginal smears", Obstet. Gynecol., 16, 354-359, 1970.
80. WEGMANN, R. and TODET-CARIDROIT, C., "Histochemical demonstration of succinic dehydrogenase by specific inhibitios and activation", J. Histochemical Cytochem., 8, 348-352, 1970.
81. MARSHALL, M.J.; GOLDBERG, D.M.; NEAL, F.E. and MILLAR, D.R., "Enzymes of glucose metabolism in carcinoma of the cervix and andometrium of the human uterus", Br. J. Cancer, 37, 990-1001, 1978.
82. LEHNINGER, A.L., Bioquímica, 2da. ed., Ed. Omega, Barcelona, 1982.
83. ALTMAN, F.P., "Quantitative dehydrogenase histochemistry with special reference to the pentose shunt dehydrogenases", Progr. Histochem. Cytochem. 4, 225-273, 1972.
84. AXERHOD, B., "Other pathways of carbohydrate metabolism", in Metabolic Pathways 3ra. De, Vol. 1, D.M. Greenberg De, Academic New York, 272-308, 1967.
85. PALAORO, L.A. y ROSSI, L., "Determinación citoquímica de glucosa-6-fosfato deshidrogenasa en células de epitelio pavimentoso de exocérvix. I: Tricomoniasis", Rev. Asoc. Bioquím. Argent., 48, 9-14, 1986.
86. SELMECI, L.E. and WEBER, G., "Increased glucose-6-phosphate dehydrogenase concentration in hepatoma 3924 A: enzymic and immunological evidence", Febs. Lett. 61, 63-67, 1976.
87. BANNASCH, P.; BENNER, U.; HACKER, H.J.; KLIMEK, F.; MAYER, D.; MOORE, M. and ZERBAN, H., "Cytochemical and biochemical microanalysis of carcinogenesis", Histochem. J., 13, 799-820, 1981.
88. HACKER, H.J. and BANNACH, P., "Histochemische Muster einiger Schlusselzyme des Kohlenhydratstoffwechsels wahrend der Hepatocarcinogenese"" Verh. dtsch. Ges. Path., 61, 481-486, 1977.
89. NUBER, R.; TEUTGH, H.F. and SASSE, D., "Metabolic zonation in thioacetamide-inducer liver cirrhosis", Histochemistry, 69, 277-278, 1980.
90. EVANS, A.W., "Determination of optimal incubation conditions for quantitative histochemical studies of glucose-6-phosphate, lactate and sucinate dehydrogenase in human oral mucose", Histochem. J., 12, 711-714, 1980.
91. HEYDEN, G., "Histochemical investigation of malignant cells", Histochemistry, 39, 327-334, 1974.
92. DUTU, R.; NEDELFA, M.; VELUDA, G. and BURCULET, V., "Cytoenzymologic investigations on carcinoma of the cervix uteri", Acta Cytol., 24, 160-166, 1980.
93. PALAORO, L.A.; ROSSI, L. and MALLOL, S., "Cytochemical assay of glucose-6-phosphate dehydrogenase in koilocytes", Acta Cytol., 32, 303-306, 1988.
94. GOLD, P. and FREEDMAN, S.O., "Demonstration of tumor specific antigen in human coIonic carcinoma by immunological tolerance and absorption techniques", J. Exp. Med., 121, 439-442, 1965.
95. GOLDEMBERG, D.M.; SHARKEY, R.M. and PRIMUS, E.J., "Carcinoembryonic antigen in histopathology: immunoperoxidase stainning for conventional tissue sections", J. Natl. Cancer Inst., 57, 11-16, 1976.
96. THOMAS, P.; TOTH, C.H.; SAINI, K.S.; JESSUP, J.M. and STEELE, J.G., "The structure, metabolism and function of the carcinoembryonic antigen gene family", Biochem. Biophys. Acta, 1032, 177-189, 1990.
97. REYNOSO, G.; CHU, T.M.; HOLIOKE, D.; COHEN, E.; NEMOTO, T.; WANG, J.J.; CHUANG, J.; GUINAN, P. and MURPHY, G.P., "Carcinoembryonic antigen in patients with different cancers", J. Am. Med. Assoc., 220, 361-365, 1972.
98. SEPPALA, M.; PIHKO, H. and RUOSLAHTI, E., "Carcinoembryonic antigen and alpha feto-protein in malignant tumors of the female genital tract", Cancer, 35, 1377-1382, 1975.
99. LINDGREN, J.; WAHLSTROM, T. and SEPPALA, M., "Tissue CEA in pre-malignant epithelial lesions and epidermoid carcinoma of uterine cervix: prognostic significance", Int. J. Cancer, 23, 48-453, 1979.
100. BYCHKOV, V.; ROTHMAN, M.; BARDOWIL, W.A., "Immunocytochemical localization of carcinoembryonic antigen (CEA), alpha-feto proteins (AFP) and human chorionic gonadotropin (HCG) in cervical neoplasia", Am. J. Clin. Pathol., 79, 414-420, 1983.
101. MC DIKEN, I.W. and RAINEY, M., "The immunological demonstration of carcinoembryonic antigen in intraepithelial and invasive squamous carcinoma of the cervix", Histopathology, 7, 475-485, 1983.
102. GOLDEMBERG, D.M.; PLETSCH, Q.A. and VAN NAGELL, J.R., "Characterization and localization of carcinoembryonic antigen in a squamous cell carcinoma of the cervix", Ginecol. Oncol., 4, 204-211, 1976.
103. BERCHTOLD, J.P., "Ultrastructural demonstration of glucose-6-phosphate dehydrogenase activity in steroid-secreting cells", Histochemistry, 63, 173-180, 1979.
104. NACHLAS, M.M.; WALKER, D.G. and SELIGMAN, A.M., "Histochemical method for demonstration of diphosphopyridine nucleotide diaphorase", J. Biophys. Biochem. Cytol., 4, 29-38, 1958.
105. VAN NOORDEN, C.J.F., "Histochemistry and cytochemistry of glucose-6-phosphate dehydrogenase", Gustv. Fischer Verlag, Stuttgart-Nueva York, 1-16, 1984.
106. VAN NOORDEN, C.J.F. and BUTCHER, R.G., "Histochemical localization of NAPH-dependent dehydrogenase activity from different tetrazolium salts", J. Histochem. Cytochem., 32, 998-1004, 1984.
107. STERNBERGER, L.A.; BARDY, P.H.; CUCULIS, J.J. and MEYER, H.G., "The unlabeled antibody-enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antiperoxidase) and its use in identification of spirochetes", J. Histochem. Cytochem, 18, 315-324, 1970.
108. CRUM, C.P.; NAGAI, N.; LEVINE, R.V. and SILVESTEIN, S., "In situ hybridization analysis of HPV16 DNA sequences in early cervical neoplasia", Am. J. Pathol., 123, 174-182, 1986.
109. COOPER, K.; HERRINGTON, C.S.; STICKLAND, J.E.; EVANS, M.F.; MC GEE, J.O.D., "Episomal and integrated human papillomavirus in cervical neoplasia shown by non-isotopic in situ hybridization", J. Clin. Pathol, 44, 990-996, 1991.
110. WALTS, A.E.; SAID, J.W. and BAUKS-SCHELEGEL, S., "Keratin and carcinoembryonic antigen in exfoliated mesothelial and malignant cells: an immunoperoxidase study", Am. J. Clin. Pathol., 80, 671-676, 1983.
111. THOMPSON, J.A.; PANDE, H.; PAXTON, R.J.; SHIVELY, L.; PADMA, A.; SIMMER, R.L.; TOOD, C.W.; RIGGS, A.D. and SHIVELY, J.E., "Molecular cloning of a gene belonging to the carcinoembryonic antigen gene family and discusion of a domain model", Proc., Natl., Acad., Sci. USA, 84, 2965-2969, 1987.
112. RUTANEN, E.M.; LINDGREN, J.; SIPPONEN, P.; STENMAN, U.H.; SAKSELA, E. and SEPPALA, M., "Carcinoembryonic antigen in malignant and non-malignant gynecologic tumors", Cancer, 42, 581-590, 1978.
113. MARIUS, N.A.P.; KLASKE, A.; HOOR, T. and GERT-JAN, F., "Cross-reactivity with normal antigen in commercial anti-CEA sera, used for immunohistology. The need for tissue controls and absortions", Am. J. Clin. Pathol., 79, 25-31, 1983.
114. HAINES, H.G.; MCCOY, J.P.; HOFHEINZ, D.E.; NG, A.B.P.; NORDVIST, S.R.B. and LEIF, R.C., "Cervical carcinoma antigens in the diagnosis of human squamous cell carcinoma of the cervix", JNCI, 66, 465-474, 1981.
115. HAINES, H.G.; NORDVIST, S.; NG, A.B. and LEIF, R.C., "Assay summary: cervical carcinoma antigens (CCA)", in: Compendium of assays for immunodiagnosis of human cancer, Herberman R.B. Ed., Nueva York, 485-487, 1979.
116. CRUM, C.R.; EGAWA, K.; FU, Y.S.; LANCASTER, W.D.; BARRON, B.; LEVINE, R.B.; FENOGLIO, C.M. and RICHART, R.M., "Atypical immature metaplasia (AIM). A subset of human papillomavirus infection of the cervix", Cancer, 51, 2214-2219, 1983.
117. PALAORO, L.A.; BLANCO, A.M. and GIONGRANDE, J.C., "Configuration of surfaces of Epithelial cells infected by Human Papillomavirus", Brazilian Journal of Oncology, 45, 9-18, 1999.
118. MITRANI-ROSEMBAUM, S.; TSIVELI, R. and TURKASPA, R., "Oestrogen stimulates differential transcription of human papillomavirus type 16 in SiHa cervical carcinoma cells", J. Gen. Virol., 70, 2227-2232, 1989.
119. CHEN, M.; POPESCU, N. and WOODWORTH, C., "Human herpesvirus 6 infects cervical epithelial cells and transactivates human papillomavirus gene expression", J. Virol., 68, 1173-1178, 1990.
120. SYRJANEN, K.; NURMI, T.; MANTUJARVI, R.; ILONEN, J.; SYRJANEN, S.; SURCEL, H.M.; YLISKOSKY, M.; VAYRYNEN, M.; CHANG, E. and SAARIKORKI, S., "HLA types in women with cervical human papillomavirus (HPV) lesions prospectively followed up to 10 years", Cytopatology, 7, 99-107, 1996.
121. ELLIS, J.R.M.; KEATING, P.J.; BAIRD, J.; HOUNSELL, E.F.; RENOUFF, D.V.; ROWE, M.; HOPKINS, D.; DUGGAN-KEEN, M.F.; BARTHOLOMEW, J.S.; YOUNG, L.S. y STERN, P.L., "The association of an HPV 16 oncogene variant with HLA-B7 has implication for vaccine design in cervical cancer", Nature Med., 1, 464-470, 1995.