Brain-stimulation reward thresholds raised by an antisense oligonucleotide for the M5 muscarinic receptor infused near dopamine cells

Journal of Neuroscience

Volumn 20, Issue 23, 2000, Pages 8861-8867

  Yeomans, J S ^a   Takeuchi, J ^a   Baptista, M ^a   Flynn, D D ^a   Lepik, K ^a   Nobrega, J ^a   Fulton, J ^a   Ralph, M R ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cholinergic; Dopamine; M5; Muscarinic; Oligodeoxynucleoti de; Reward; Self stimulation

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MUSCARINIC M5 RECEPTOR; OLIGONUCLEOTIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; REWARD; SELF STIMULATION; TASK PERFORMANCE; VENTRAL TEGMENTUM;

EID: 0034554771     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-23-08861.2000     Document Type: Article

References (61)

1. Intracerebroventricular treatment with an antisense oligodeoxynucleotide to K-opioid receptors inhibited K-agonist-induced analgesia in rats
2. Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion
3. Evidence implicating descending fibers in self-stimulation of the medial forebrain bundle
4. Modulation of dopamine efflux in the striatum following cholinergic stimulation of the substantia nigra in intact and pedunculopontine tegmental nucleus-lesioned rats
5. Modulation of dopamine efflux in the nucleus accumbens after cholinergic stimulation of the ventral tegmental area in intact, pedunculopontine tegmental nucleus-lesioned, and laterodorsal tegmental nucleus-lesioned rats
6. Cholinergic input to dopaminergic neurons in the substantia nigra: A double immunocytochemical study
7. Identification of a family of muscarinic acetylcholine receptor genes
8. Cloning and expression of the human and rat m5 muscarinic receptor genes
9. A microcomputer-based method for physiologically interpretable measurement of the rewarding efficacy of brain stimulation
10. Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic neurons
11. Nicotine maintains robust self-administration in rats on a limited-access schedule
12. The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
13. Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area
14. Therepeutic applications of oligonucleotides
15. Reward versus performance in self-stimulation: Electrode specific effects of alpha-methyl-p-tyrosine on reward in the rat
16. Pharmacological strategies to selectively label and localize muscarinic receptor subtypes
17. Decrease and recovery of choline acetyltransferase activity in medial thalamus and ventral tegmental area after destruction of pedunculopontine areas in the rat
18. Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta
19. Pimozide and amphetamine have opposite effects on the reward summation function
20. Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
21. Cholinergic antagonists in ventral tegmentum elevate frequency thresholds for lateral hypothalamic and brainstem self-stimulation
22. Differential effects of atropine, procaine and dopamine in the rat ventral tegmentum on lateral hypothalamic rewarding brain stimulation
23. Electrophysiology of ascending, possibly cholinergic neurons in the rat laterodorsal tegmental nucleus: Comparison with monoamine neurons
24. Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor
25. Muscarine depolarizes substantia nigra zona compacta and ventral tegmental neurons in vitro through M1-like receptors
26. Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies
27. Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain
28. Behavioral measures of conduction velocity and refractory period for reward-relevant axons in the anterior LH and VTA
29. Locomotion induced by ventral tegmental microinjections of a nicotinic agonist
30. Pharmacokinetics and delivery of oligonucleotides to the brain
31. Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
32. Effects of intrahypothalamic administration of antisense DNA for progesterone receptor mRNA on reproductive behavior and progesterone receptor immunore-activity in female rats
33. The rat brain in stereotaxic coordinates, 2nd Edition
34. Primary structure and biochemical properties of an M2 muscannic receptor
35. The role of dopamine in maintaining intracranial self-stimulation in the ventral tegmentum, nucleus accumhens and medial prefrontal cortex
36. In vivo applications of antisense oligonucleotides for peptide research
37. Acetylcholine release in ventral tegmental area by hypothalamic self-stimulation, eating and drinking
38. Locomotor activity in rats after administration of nicotinic agonists intracerebrally
39. Potentiation of central reward by localized perfusion of acetylcholine and 5-hydroxytryptamine
40. The M5 (m5) receptor subtype: Fact or fiction?
41. The action of norepinephrine in the rat hippocampus. II: Activation of the input pathway
42. Regional neuroleptic microinjections indicate a role for nucleus accumbens in lateral hypothalamic self-stimulation reward
43. Sequence-specific impairment of learning by c-jun antisense oligonucleotides
44. Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry
45. Gene inhibition using antisense oligodeoxynucleotides
46. Antisense oligonucleotide strategies in neuropharmacology
47. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides
48. Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia
49. Catecholamine theories of reward: A critical review
50. Development of antisera for m4 and m5 muscarinic cholinergic receptors: Distribution of m4 and m5 receptors in rat brain
51. Quantitative measurement of neural post-stimulation excitability with behavioral methods
52. Absolute refractory periods of self-stimulation neurons
53. Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia
54. Both nicotinic and muscarinic receptors in ventral tegmental area contribute to brain-stimulation reward
55. Cholinergic involvement in lateral hypothalamic self-stimulation
56. Refractory period estimates are lengthened by reducing electrode tip exposure or increasing current
57. Excitability properties of medial forebrain bundle axons of putative A10 dopamine cells
58. Rewarding brain stimulation: Role of tegmental cholinergic neurons that activate dopamine neurons
59. The role of nicotinic and muscarinic (m5) receptors in the ventral tegmental area in intracranial self-stimulation
60. Reduction in muscarinic receptors by antisense oligonucleotide
61. Antisense oligodeoxynucleotide reduces brain D2 receptors: Behavioral correlates