From genotype to phenotype: Buffering mechanisms and the storage of genetic information

BioEssays

Volumn 22, Issue 12, 2000, Pages 1095-1105

  Rutherford, Suzanne L ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; EVOLUTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MOLECULAR EVOLUTION; PHENOTYPE; REVIEW;

ANIMALS; EVOLUTION; EVOLUTION, MOLECULAR; GENOTYPE; HUMANS; MODELS, GENETIC; PHENOTYPE; VARIATION (GENETICS);

EID: 0034546905     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-1878(200012)22:12<1095::AID-BIES7>3.0.CO;2-A     Document Type: Review

References (72)

1. Hsp90 as a capacitor for morphological evolution
2. Robustness in bacterial chemotaxis
3. Robustness against mutations in genetic networks of yeast
4. Canalization in evolutionary genetics: A stabilizing theory?
5. Evolvability
6. Canalization, genetic assimilation and preadaptation. A quantitative genetic model
7. Environment and cancer: Who are susceptible?
8. Genetic dissection of complex traits
9. Variability of eyeless
10. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
11. The master control gene for morphogenesis and evolution of the eye
12. The relation between expressivity and selection against eyeless in Drosophila melanogaster
13. Gene-environment interactions of the eyeless mutant in Drosophila melanogaster
14. Canalization: Genetic and developmental aspects
15. Developmental abnormalities in Drosophila induced by heat shock
16. Genetic assimilation of an acquired character
17. Selection for an invariant character-'vibrissae number'- in the house mouse
18. The genetics of common diseases: The implications of population variability
19. A quanitative description of membrane current and its application to conduction and excitation in nerve
20. Protein molecules as computational elements in living cells
21. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
22. Determination of neuronal cell fate: Lessons from the R7 neuron of Drosophila
23. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling
24. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila
25. Resolving the sevenless pathway using sensitized genetic backgrounds
26. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
27. Mutations modulating Raf signaling in Drosophila eye development
28. Naturally occurring genetic variation affects Drosophila photoreceptor determination
29. Cdc37 is a molecular chaperone with specific functions in signal transduction
30. Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila
31. Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila
32. Protein folding and the regulation of signaling pathways
33. Hsp90's secrets unfold: New insights from structural and functional studies
34. Reduced levels of hsp90 compromise steroid receptor action in vivo
35. Heat-shock protein hsp90 governs the activity of pp60v-src kinase
36. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
37. The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila
38. Experiments on canalizing selection
39. Quantitative modeling of stochastic systems in molecular biology by using stochastic Petri nets
40. Fluctuating asymmetry analyses: A primer
41. Recent developments in the genetics of schizophrenia
42. Developmental constraints and evolution
43. The heritability of fluctuating asymmetry and the genetic control of developmental stability
44. A diet-induced developmental polymorphism in a caterpillar
45. Effect of polymorphism in the Drosophila regulatory gene Ultrabithorax on homeotic stability
46. The differential genetic and environmental canalization of fitness components in Drosophila melanogaster
47. Emergent properties of networks of biological signaling pathways
48. From molecular to modular cell biology
49. The molecular basis of dominance
50. Robustness in simple biochemical networks
51. Genome complexity, robustness and genetic interactions in digital organisms
52. The segment polarity network is a robust developmental module
53. Activity-dependent scaling of quantal amplitude in neocortical neurons
54. Homeostatic plasticity in neuronal networks: The more things change, the more they stay the same
55. The evolution of canalization and the breaking of von Baer's laws: Modeling the evolution of development with epistasis
56. Evolution of developmental mechanisms in nematodes
57. The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways
58. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation
59. Activation of the Saccharomyces cerevisiae filamentation/invasion pathway by osmotic stress in high-osmolarity glycogen pathway mutants
60. Functional analysis of eve stripe 2 enhancer evolution in Drosophila: Rules governing conservation and change
61. Evidence for stabilizing selection in a eukaryotic enhancer element