Functional Cyp2e1 is required for subtantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse

Archives of Toxicology

Volumn 74, Issue 10, 2000, Pages 582-586

  Iba, M M ^a   Fung, J ^a   Gonzalez, F J ^b  

^a RUTGERS UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

2,5 Hexanedione; Biotransformation; Cyp2e1 knockout mouse; n Hexane

Indexed keywords

1,4 DIKETONE; ACETONYLACETONE; ALKANE; CYTOCHROME P450 2E1; HEXANE; HEXANOL;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DETOXIFICATION; GENE DELETION; IN VIVO STUDY; MALE; METABOLITE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; URINE LEVEL;

ADHESIVES; ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 CYP2E1; HEXANES; HEXANOLS; HEXANONES; HOMOZYGOTE; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, KNOCKOUT;

EID: 0034541786     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000182     Document Type: Article

References (37)

1. Toxic polyneuropathies after sniffing a glue thinner
2. Biotransformation of n-hexane and methyl n-butyl ketone in guinea pigs and mice
3. Metabolism of n-hexane by rat liver and extrahepatic tissues and the effect of cytochrome P-450 inducers
4. Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance
5. 14C-labeled methyl n-butyl ketone in the rat
6. 1 mice after inhalation exposure
7. 4,5-Dihydroxy-2-hexanone: A new metabolite of n-hexane and of 2,5-hexanedione in rat urine
8. The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man
9. Pharmacokinetics of the neurotoxin n-hexane in rat and man
10. Influence of inducers and inhibitors on the hydroxylation pattern of n-hexane in rat liver microsomes
11. Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein cross-linking
12. n-Hexane neuropathy
13. Urinary 2,5-hexanedione increases with potentiation of neurotoxicity in chronic exposure to n-hexane and methyl ethyl ketone
14. Combined effects of n-hexane and toluene on norepinephrine and dopamine levels in rat brain tissues after long-term exposures
15. Oxidative mechanisms in nigral cell death in Parkinson's disease
16. Effect of n-hexane inhalation on monooxygenase system in mice liver microsomes
17. The relative neurotoxicity of n-butyl ketone, n-hexane and their metabolites
18. Role of CYP2E1 in the hepatotoxicity of acetaminophen
19. Cytochrome P-4502E1: Its physiological and pathological role
20. Effects of acute n-hexane and 2,5-hexanedione treatment on the striatal dopaminergic system in mice
21. Toxic polyneuropathy due to glue-sniffing
22. Position specificity in n-hexane hydroxylation by two forms of cytochrome P-450 in rat liver microsomes
23. Immunochemical detection of cytochrome P450 isozymes induced in rat liver by n-hexane, 2-hexanone and acetonyl acetone
24. The influence of n-hexane treatment on the glucuronic acid pathway and activity of some drug-metabolizing enzymes in guinea pig
25. An experimental study on the neurotoxicity of n-hexane and metabolites: Hexanol-1 and hexanol-2
26. Urinary excretion of n-hexane metabolites. A comparative study in rat, rabbit and monkey
27. n-Hexane induces parkinsonism in rodents
28. Cytochrome P450 isozyme induction by methyl ethyl ketone and m-xylene in rat liver
29. Effect of methyl ethyl ketone pretreatment on hepatic mixed-function oxidase activity and on in vivo metabolism of n-hexane
30. Degeneration in central and peripheral nervous system produced by pure n-hexane: An experimental study
31. On the specific molecular configuration of neurotoxic aliphatic hexacarbon compounds causing central-peripheral distal axonopathy
32. Parkinsonism caused by petroleum waste ingestion
33. Xylene induces a cytochrome P-450 isozyme in rat liver similar to the major isozyme induced by phenobarbital
34. Rat lung and liver microsomal cytochrome P-450 isozymes involved in the hydroxylation of n-hexane
35. Parkinsonism induced by solvent abuse
36. Intoxication polyneuritis in the workers exposed to n-hexane