A newly characterized human endometrial adenocarcinoma cell line (CAC-1) differentiates in response to retinoic acid treatment

Experimental and Molecular Pathology

Volumn 69, Issue 3, 2000, Pages 175-191

  Carter, Charleata A ^a   Madden, Victoria J ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Endometrium; F actin; Protein kinase C; Retinoic acid

Indexed keywords

CYTOKERATIN; F ACTIN; MARCKS PROTEIN; PROTEIN KINASE C; RETINOIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CARCINOMA CELL; CASE REPORT; CELL ADHESION; CELL GROWTH; CELL LINE; CONTROLLED STUDY; DRUG EFFECT; ENDOMETRIUM CARCINOMA; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; PROTEIN CROSS LINKING; TREATMENT OUTCOME;

EID: 0034541377     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1006/exmp.2000.2334     Document Type: Article

References (52)

1. The MARCKS brothers: A family of protein kinase C substrates
2. Protein kinase C regulates MARCKS cycling between the plasma membrane and lysosomes in fibroblasts
3. The protein kinase C family
4. The cytoskeleton in cancer cells
5. The MARCKS family of cellular protein kinase C substrates
6. Phase I/II trial of all-trans retinoic acid and tamoxifen in patients with advanced breast cancer
7. Fluorescent laser scanning microscopy of F-actin disruption in human endometrial stromal cells expressing the SV40 large T antigen and the EJ ras oncogene
8. Differential effects of dioctanoylglycerol on fibronectin localization in normal, partially transformed, and malignant human endometrial stromal cells
9. Alterations in the localization of F-actin, fibronectin and thrombospondin occur early in multistep transformation of rat tracheal epithelial cells
10. Effects of retinoic acid on cell differentiation and reversion toward normal in human endometrial adenocarcinoma (RL95-2) cells
11. State of differentiation affects the response of endometrial adenocarcinoma cells to retinoic acid
12. Cytoskeletal reorganization induced by retinoic acid treatment of human endometrial adenocarcinoma (RL95-2) cells is correlated with alterations in protein kinase C-α
13. Biology of disease. Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: Strategies, applications and limitations
14. Clinical implications of fos and jun expressions and protein kinase activity in endometrial cancers
15. Large-scale sequencing of two regions in human chromosome 7q22: Analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes
16. Phosphorylation-regulated calmodulin binding to prominent cellular substrate for protein kinase C
17. Cancer Statistics, 2000
18. Inhibition of AIDS-Kaposi's sarcoma cell proliferation following retinoic acid receptor activation
19. MARCKS is an actin filament cross-linking protein regulated by protein kinase C and calcium-calmodulin
20. Inhibition of K1735-M2 melanoma cell invasion in vitro by retinoic acid
21. Effects of steroid hormones and antisteroids on alkaline phosphatase activity in human endometrial cancer cells (Ishikawa line)
22. Protein kinase C isoenzymes: Divergence in signal transduction?
23. Association of type 3 PKC with focal contacts in rat embryo fibroblasts
24. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
25. Metastatic adenocarcinoma of the endometrium treated with 13-cis-retinoic acid plus interferon-α
26. Formation of vinculin plaques precedes other cytoskeletal changes during retinoic acid-induced teratocarcinoma cell differentiation
27. Mapping of the human retinoic acid receptor to the q21 band of chromosome 17
28. Fluorescence in situ hybridization in cervical smears: Detection of numerical aberrations of chromosomes 7, 3 and X and relationship to HPV infection
29. Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin
30. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
31. MARCKS regulates membrane ruffling and cell spreading
32. Studies and perspectives of protein kinase C
33. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
34. The family of protein kinase C for signal transduction
35. Numerical chromosome alterations in colorectal carcinomas detected by fluorescence in situ hybridization. Relationship to 17p and 18q allelic losses
36. Cancer as a disease of DNA organization and dynamic cell structure
37. Direct interaction of all-trans-retinoic acid with protein kinase C: Implications for PKC signaling and cancer therapy
38. Cellular F-actin levels as a marker for cellular transformation: Relationship to cell division and differentiation
39. KLE: A cell line with defective estrogen receptor derived from undifferentiated endometrial cancer
40. Retinoic acid enhances adhesiveness, laminin and integrin B1 synthesis and retinoic acid receptor expression in F9 teratocarcinoma cells
41. Endometrial stromal sarcoma with clonal complex chromosome abnormalities
42. Clinical and pathological significance of numerical aberrationss of chromosomes 11 and 17 in colorectal neoplasms
43. Higher frequencies of numerical abberations of chromosome 17 in primary gastric cancers are associated with lymph node metastasis
44. Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane
45. Pathology and grading of endometrial adenocarcinomas
46. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
47. Vitamin A in animal and human nutrition
48. Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture
49. Growth factors, oncogenes, and multistage carcinogenesis
50. Protein kinase C involvement in focal adhesion formation
51. Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells