The role of VEGF and thrombospondins in skin angiogenesis

Journal of Dermatological Science

Volumn 24, Issue SUPPL. 1, 2000, Pages

  Detmar, Michael ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Skin; TSP 1; TSP 2; VEGF

Indexed keywords

THROMBOSPONDIN; THROMBOSPONDIN 1; THROMBOSPONDIN 2; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; BLOOD VESSEL PERMEABILITY; CANCER GROWTH; CELL MIGRATION; CELL PROLIFERATION; DERMIS; HAIR FOLLICLE; HUMAN; INFLAMMATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; REVIEW; SKIN; SKIN CANCER; SQUAMOUS CELL CARCINOMA; TISSUE REPAIR; VASCULARIZATION;

EID: 0034538040     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(00)00145-6     Document Type: Article

References (30)

1. Mechanisms of angiogenesis and arteriogenesis
2. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
3. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
4. Neuropilin-1 is expressed by endothelial cells and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
5. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells
6. 3 integrin, osteopontin, and thrombin
7. 1integrins
8. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis
9. Molecular regulation of angiogenesis in the skin
10. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
11. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis
12. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin
13. Identification of a human VPF/VEGF 3′ untranslated region mediating hypoxia-induced mRNA stability
14. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
15. Halting angiogenesis suppresses carcinoma cell invasion
16. Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas
17. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
18. Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma
19. Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3
20. Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1
21. Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity
22. Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human squamous cell carcinomas
23. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells
24. Thrombospondin-1 is a major activator of TGF-b1 in vivo
25. Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats
26. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice
27. Thrombospondins: Structure and regulation of expression
28. Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis
29. Tumor angiogenesis
30. Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis