The effect of three broad-spectrum antimicrobials on mononuclear cell responses to encapsulated bacteria: Evidence for down-regulation of cytokine mRNA transcription by trovafloxacin

Journal of Antimicrobial Chemotherapy

Volumn 46, Issue 6, 2000, Pages 921-929

  Purswani, M ^a   Eckert, S ^a   Arora, H ^a   Johann Liang, R ^a   Noel, G J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALATROFLOXACIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BACTERIAL DNA; BACTERIAL ENZYME; BACTERIAL RNA; BACTERIUM LIPOPOLYSACCHARIDE; CEFTRIAXONE; CIPROFLOXACIN; COMPLEMENTARY DNA; CYTOKINE; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOTEICHOIC ACID; MESSENGER RNA; PLASMA PROTEIN; QUINOLONE DERIVATIVE; RIBONUCLEASE; SODIUM CHLORIDE; TROVAFLOXACIN; TUMOR NECROSIS FACTOR ALPHA; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL MEMBRANE; BACTERIOLYSIS; BACTERIUM CULTURE; CELL ACTIVITY; CELL CULTURE; CELL KILLING; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG ACTIVITY; DRUG METABOLISM; GENETIC TRANSCRIPTION; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MONONUCLEAR CELL; MOUSE; NONHUMAN; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SEPSIS; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION REGULATION;

EID: 0034532380     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/46.6.921     Document Type: Article

References (27)

1. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction and therapy
2. Role of cytokines in acute-phase response
3. Mode of action of anti-lipopolysaccharide-binding protein antibodies for prevention of endotoxemic shock in mice
4. Adjunctive therapy for septic shock: A review of experimental approaches
5. Effects of antibiotics on the immune response
6. Antibiotic effects on bacterial viability, toxin production and host responses
7. Novel therapies in streptococcal toxic shock syndrome: Attenuation of virulence factor expression and modulation of the host response
8. Modulation of inflammation and cachectin activity in relation to treatment of experimental Haemophilus influenzae type b meningitis
9. Erythromycin inhibits tumor necrosis factor alpha and interleukin-6 production induced by heat-killed Streptococcus pneumoniae in whole blood
10. Immunological aspects of new quinolones
11. Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: Correlation with inhibition of cytokine secretion
12. Effect of trovafloxacin on production of cytokines by human monocytes
13. Increased interleukin-2 transcription in murine lymphocytes by ciprofloxacin
14. Pharmacokinetics of ceftriaxone in patients with typhoid fever
15. Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligram intravenously) for antibiotic prophylaxis in thoracic surgery
16. Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects
17. Pharmacokinetics and safety of trovafloxacin (CP-99,219), a new quinolone antibiotic, following administration of single oral doses to healthy male volunteers
18. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
19. Fluorinated 4-quinolones induce hyperproduction of interleukin 2
20. Evidence that the antibiotic ciprofloxacin counteracts cyclosporine-dependent suppression of cytokine production
21. Trovafloxacin delays the antibiotic-induced inflammatory response in experimental pneumococcal meningitis
22. Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue cultured epithelial cells
23. 18F]trovafloxacin in healthy human subjects studied with positron emission tomography
24. Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems
25. Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases
26. Cerebrospinal fluid cachectin/tumor necrosis factor-α and platelet-activating factor concentrations and severity of bacterial meningitis in children
27. Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis