Inhibition of platelet function by GSTM1-null human peripheral lymphocytes exposed to benzo(a)pyrene-induced challenge

Cell Biology and Toxicology

Volumn 16, Issue 5, 2000, Pages 313-323

  Onaran, I ^a   Ozaydin, A ^a   Özdas, Ş B ^b   Ulutin, T ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Benzo(a)pyrene; GSTM1; Lymphocyte; Oxidative stress; Platelet; Polymorphism

Indexed keywords

BENZO[A]PYRENE; CARBONYL DERIVATIVE; CUMENE HYDROPEROXIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; PARINARIC ACID; STILBENE OXIDE; THIOBARBITURIC ACID;

ADULT; ARTICLE; CELL ISOLATION; CELL VIABILITY; CIGARETTE SMOKING; EPIDEMIOLOGICAL DATA; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPOTHESIS; MALE; NULL CELL; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; TOBACCO;

ADULT; BENZENE DERIVATIVES; BENZO(A)PYRENE; BLOOD PLATELETS; FEMALE; GLUTATHIONE TRANSFERASE; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MALE; MALONDIALDEHYDE; OXIDANTS; OXIDATIVE STRESS; STILBENES;

EID: 0034531592     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026750431055     Document Type: Article

References (39)

1. Detoxication of base propenals and other α, βunsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases
2. Effect of cigarette smoking upon in-vivo platelet function in man
3. Involvement of hydrogen and lipid peroxides in acute tobacco smoking-induced platelet hyperactivity
4. Isolation of mononuclear cells by one centrifugation of granulacytes by combining centrifugation and sedimentation
5. Effect of neutral proteasas from blood leukocytes on human platelets
6. Free-radical chemistry of cigarette smoke and its toxicological implications
7. Determination of glutathione and glutathione disulfide using glulathione reductase and 2-vinylpiridine
8. Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer
9. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer, chemoprotection and drug resistance
10. Supression of the in vitro humoral response of mouse splenocytes by benzo(a)pyrene metabolites and inhibition of benzo(a)pyrene-induced immunosuppression by alpha-napthoflavine
11. Lipid peroxidation of human erythrocyte ghosts induced by organic hydroperoxides
12. Deficiency of glutathione S-transferases T1 and M1 as heritable factors of increased cutaneous UV sensitivity
13. Parinaric acid as a sensitive fluorescent probe for the determination of lipid peroxidation
14. Identification of genes differentially expressed in vascular smooth muscle cells following benzo(a)pyrene challenge: Implications for chemical atherogenesis
15. Eicosanoid interactions between platelets, endothelial cells, and neutrophils
16. A simple salting out procedure for extracting DNA from nucleated cells
17. Effects of benzo(a)pyrene on concanavallin A-stimulated human peripheral blood mononuclear cells in vitro: Inhibition of proliferation but no effects on parameters related to the G1 phase of the cell cycle
18. Environmental air pollution and DNA adducts in Copenhagen bus drivers effect of GSTM1 and NAT2 genotypes on adduct levels
19. Cytogenetic markers of susceptibility: Influence of polymorphic carcinogen-metabolizing enzymes
20. Are individuals with glutathione S-transferase GSTT1 null genotype more susceptible to in vitro oxidative damage?
21. Glutathione S-transferases: Gene structure, regulation, and biological function
22. Separation and characterization of aldehydic products of lipid peroxidation stimulated by CC14 or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions
23. Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity
24. Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility - A review
25. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor
26. Epithelial ovarian cancer: Influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression
27. The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics
28. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes
29. Glutathione S-transferases of human lung: Characterization and evaluation of the protective role of the α-class isozymes against lipid peroxidation
30. Redox regulation of signal transduction: Tyrosine phosphorylation and calcium flux
31. Glutathione S-transferase polymorphisms: Influence on susceptibility to cancer
32. Free radicals of benzo(a)pyrene and derivatives
33. Glutathione peroxidase activity in various types of blood cells in multiple sclerosis
34. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione
35. Inactivation of enzymes of the glutathione antioxidant system by treatment of cultured human keratinocytes with peroxides
36. Gene structure, expression and chromosomal localization of murine Theta class glutathione mGSTT1-1
37. Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage
38. Cumene hydroperoxide-induced chemiluminecence in human erythrocytes: Effect of antioxidants and sulfhydryl compounds
39. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer