Selective phenylalkylamine block of IKr over other K+ currents in guinea-pig ventricular myocytes

British Journal of Pharmacology

Volumn 131, Issue 8, 2000, Pages 1809-1816

  Jones, S E ^a   Missan, S ^a   Zhabyeyev, P ^a   McDonald, T F ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

D600; Guinea pig ventricular myocytes; Nisoldipine; Verapamil

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; GALLOPAMIL; NISOLDIPINE; PHENYLALKYLAMINE; POTASSIUM CHANNEL; VERAPAMIL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE; IC 50; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 0034531495     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703758     Document Type: Article

References (41)

1. + current in patchperforated GH3 anterior pituitary cells
2. Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. III. Effects of the optical isomers on transmembrane action potentials
3. + channels involved in long QT syndromes, are targets for calcium channel blockers
4. Effect of verapamil on the normal action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibers
5. + channel block by verapamil and related compounds in rat alveolar epithelial cells
6. Modulation of the delayed rectifier potassium current in frog cardiomyocytes by beta-adrenergic agonists and magnesium
7. K, by flecainide and E-4031 in cat ventricular myocytes
8. Ks in guinea-pig isolated ventricular myocytes
9. Mechanisms of verapamil inhibition of action potential firing in rat intracardiac ganglion neurons
10. + channels
11. Ionic currents in single isolated bullfrog atrial cells
12. Quinidine-induced inhibition of transient outward current in cardiac muscle
13. + currents in sheep parotid secretory cells
14. Mechanisms of potassium channel block in rat alveolar epithelial cells
15. Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes
16. + current by therapeutic concentrations of the antispasmodic agent terodiline
17. Nisoldipine: A new, more selective calcium current blocker in cardiac Purkinje fibers
18. Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers
19. Effect of internal fluoride and phosphate on membrane currents during intracellular dialysis of nerve cells
20. The calcium antagonist D600 inhibits calcium-independent transient outward current in isolated rat ventricular myocytes
21. Pharmacological analysis of voltage-dependent potassium currents in cultured skeletal myocytes of the frog Rana temporaria
22. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
23. Cat ventricular muscle treated with D600: Effects on calcium and potassium currents
24. Cat ventricular muscle treated with D600: Characteristics of calcium channel block and unblock
25. A minK-HERG complex regulates the cardiac potassium current I(Kr)
26. On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium
27. Action potentials, ionic currents and cell water in guinea pig ventricular preparations exposed to dimethyl sulfoxide
28. + current in sinoatrial node pacemaker activity
29. + current in small-cell lung cancer cells
30. + channel cloned from human heart
31. Kr potassium channel
32. + current. Differential sensitivity to block by class III antiarrhythmic agents
33. + currents
34. + current in guinea pig ventricular cardiomyocytes
35. + currents in intermediate cells in the cochlea of gerbils: A possible contribution to the endocochlear potential
36. + channel currents in the basolateral membrane of villus enterocytes isolated from guinea pig small intestine
37. Verapamil block of the delayed rectifier K current in chick embryo dorsal root ganglion neurons
38. HERG, a human inward rectifier in the voltage-gated potassium channel family
39. + currents by nifedipine
40. Multiple modulations of action potential duration by different calcium channel blocking agents in guinea pig ventricular myocytes
41. Mechanism of block and identification of the verapamil binding domain to HERG potassium channels