Mechanisms of [2,3-butanedione bis(N4-dimethylthiosemicarbazone)]zinc (Zn-ATSM2)-induced protection of cultured hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity

Japanese Journal of Pharmacology

Volumn 84, Issue 3, 2000, Pages 334-338

  Kubota, M ^a   Iida, Y ^a   Magata, Y ^a   Kitamura, Y ^a   Kawashima, H ^a   Saji, H ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Glutamate; Hippocampal cell culture; N Methyl D aspartate receptor; Neuroprotection; Zinc

Indexed keywords

CALCIUM; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG; ZINC COMPLEX; [2,3 BUTANEDIONE BIS(N4 DIMETHYLTHIOSEMICARBAZONE)]ZINC;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; HIPPOCAMPUS; IN VITRO STUDY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; RECEPTOR BLOCKING;

EID: 0034531140     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.84.334     Document Type: Article

References (30)

1. Glutamate and the patholophysiology of hypoxic-ischaemic brain damage
2. The role of glutamate neurotoxicity in hypoxic-ischaemic neuronal death
3. Cholecystokinin induced protection of cultured cortical neurons against glutamate neurotoxicity
4. Protective action of dopamine against glutamate neurotoxicity in the retina
5. Protective action of zinc against glutamate neurotoxicity in cultured retinal neurons
6. Zinc and the central nervous system
7. 3H]MK-801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: Evidence for multiple regulatory sites
8. Multiple sites for the regulation of the N-methyl-D-aspartate receptor
9. 2+: An endogenous modulator of ligand- and voltage-gated ion channels
10. Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc
11. The preparation of some thiosemicarbazones and their copper complexes
12. Brain permeable zinc complex with neuroprotective action
13. Neuroprotective effect of zinc complex with high membrane permeability after transient cerebral ischemia in the rat
14. Rat hippocampal neurons in dispersed cell culture
15. 2+ channels in primary cultures of granule cells
16. Concerning the role of zinc in take antitumor activity of 3-ethoxy-2-oxobutylaldehyde bis(thiosemicarbazide) zinc(II) and related chelates
17. Mechanisms of cholecystokinin-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxocity
18. 2+ indicators with greatly improved fluorescence properties
19. Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes
20. Zinc alters excitatory amino acid neurotoxicity on cortical neurons
21. Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons
22. Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-D-aspartate receptors
23. 2+ permeates calcium permeable AMPA/kainite channels and triggers selective neural injury
24. Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels
25. 2+ induced neurotoxicity in rat primary cortical cultures: Involvement of L-type calcium channels
26. Corticosterone attenuates zinc-induced neurotoxicity in primary hippocampal cultures
27. Rapid disappearance of zinc positive terminals in focal brain ischemia
28. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals
29. Possible mechanisms limiting N-methyl-D-aspartate receptor overactivation and the therapeutic efficacy of N-methyl-D-aspartate antagonists
30. 2+ antagonize NMDA and GABA responses of hippocampal neurons