Thrombolysis by thienopyridines and their congeners

Journal of Physiology and Pharmacology

Volumn 51, Issue 4, 2000, Pages 683-693

  Gryglewski, R J ^a,c   Dupin, J P ^b   Uracz, W ^a   Swies J ^a   Madej, J ^a   Hou, G ^b   Gravier, D ^b   Casadebaig, F ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Clopidogrel; Prostacyclin; Thienopyridine and pyridopyrimidine derivatives; Thrombolysis; Ticlopidine; Tissue plasminogen activator; Vascular endothelium

Indexed keywords

CLOPIDOGREL; PROSTACYCLIN; THIENO[3,2 C]PYRIDINE DERIVATIVE; TICLOPIDINE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; BLOOD CLOT LYSIS; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; ENANTIOMER; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; EXTRACORPOREAL CIRCULATION; FIBRINOLYTIC AGENTS; HUMANS; MALE; MOLECULAR STRUCTURE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TICLOPIDINE;

EID: 0034526547     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (35)

1. Ticlopidine: A promise for the prevention and treatment of thrombosis and its complications
2. Clopidogrel
3. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
4. What have we learned from recent anti-platelet trials?
5. The CAPRIE trial: Culmination of the preregistration program for clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events. Clopidogrel versus aspirin in patients at risk of ischaemic events
6. Ticlopidine treatment reduces the progression of nonproliferative diabetic retinopathy
7. Purinoceptors on blood platelets: Further pharmacological and clinical evidence to suggest the presence of two ADP receptors
8. Ultrastructural studies of platelet aggregates from human subjects receiving clopidogrel and from a patient with an inherited defect of an ADP-dependent pathway of platelet activation
9. Characterization of P2×1 purinoreceptors on rat platelets: Effect of clopidogrel
10. Role of P2YI purinoceptor in ADP-induced platelet activation
11. Specific inhibition of ADP-induced platelet aggregation by clopidogrel in vitro
12. Thrombolytic action of ticlopidine: Possible mechanisms
13. Effect of ticlopidine on streptokinase-induced thrombolysis in rats
14. Unusual effects of aspirin on ticlopidine-induced thrombolysis
15. Thienopyridines: Effects on cultured endothelial cells
16. Angiogenesis inhibitor SR 25989 upregulates thrombospondin-1 expression in human vascular endothelial cells and foreskin fibroblasts
17. 2-Amino-thionaphtene
18. 2-Amino-thiophene aus methylenaktiven nitrilen, carbonylverbindungen und schwefel
19. Thieno[2,3-d]pyrimidin-4(3H)-one derivatives and 1,2-dihydrogenated homologues: Synthesis, enhanced in vitro antiaggregant activity for reduced compounds
20. Pyrido[2,3-d]pyrimidin-4(3H)-one derivatives and 1,2,3,4-tetrahydro- pyrido[2,3-d]pyrimidine derivatives: Synthesis and in vitro study of their activity against platelet aggregation
21. In vivo method for quantitation for anti-platelet potency of drugs
22. Streptokinase-induced changes in the structure of platelets. Ex vivo study
23. Axial dependence of collagen-induced thrombus formation in flowing non-anticoagulated human blood. Anti-platelet drugs impair thrombus growth and increase platelet-collagen adhesion
24. Combination tissue plasminogen activator and ticlopidine therapy in a rabbit model of acute thromboembolic stroke
25. Clopidogrel is more effective than aspirin as adjuvant treatment to prevent reocclusion after thrombolysis
26. Effect of aspirin on the fibrinolytic response in perfused rat hindquarters
27. Modulation of plasma fibrinogen levels by ticlopidine in healthy volunteers and patients with stable angina pectoris
28. Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled
29. Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells
30. Vasomodulatory action of clopidogrel and ticlopidine
31. Modulation of vasoconstriction by clopidogrel and ticlopidine
32. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
33. Effects of antihypertensive therapy on factors mediating endothelium-dependent relaxation in rats treated chronically with L-NAME
34. Effects of captopril and ticlopidine, alone or in combination, in hypertensive patients with intermittent claudication
35. Acute hemodynamic interaction of aspirin and ticlopidine with enalapril: Results of a double-blind, randomized comparative-trial