Presynaptic modulation of the norepinephrine-induced β-adrenergic receptor desensitization phenomenon in vivo

Journal of Cardiac Failure

Volumn 6, Issue 4, 2000, Pages 350-358

  Nakamura, I ^a   Yoshikawa, T ^a   Anzai, T ^a   Baba, A ^a   Iwata, M ^a   Wainai, Y ^a   Suzuki, M ^a   Ogawa, S ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenylyl cyclase; Denervation; G protein coupled receptor kinase; Heart failure

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; NORADRENALIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CELL CULTURE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DENERVATION; DESENSITIZATION; ENZYME ACTIVITY; IMMUNOREACTIVITY; IN VIVO STUDY; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RABBIT; RECEPTOR AFFINITY; RECEPTOR DENSITY; REGULATORY MECHANISM;

EID: 0034526433     PISSN: 10719164     EISSN: None     Source Type: Journal    
DOI: 10.1054/jcaf.2000.19223     Document Type: Article

References (47)

1. β1 and β2 adrenergic receptor subpopulations in normal and failing human ventricular myocardium: Coupling of both receptor subtypes to muscle contraction and selective β1 receptor downregulation in heart failure
2. Differences in β-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy
3. Increase of the 40000-mol wt pertussis toxin substrate (G protein) in the failing human heart
4. Down-regulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs
5. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure
6. Alterations in sarcoplasmic reticulum gene expression in human heart failure
7. Reduced β1 receptor messenger RNA abundance in the failing human heart
8. Diverse G protein and β-adrenergic receptor mRNA expression in normal and failing porcine hearts
9. Altered expression of β-adrenergic receptor kinase and β1-adrenergic receptors in the failing human heart
10. Desensitization of the human β1-adrenergic receptor
11. cAMP response element binding protein is expressed and phosphorylated in the human heart
12. Desensitization of the β-adrenergic receptor of frog erythrocytes
13. Mechanisms of membrane-receptor regulation
14. Rapid recovery of cardiac β-adrenergic receptors after isoproterenol-induced "down"-regulation
15. Phosphorylation/dephosphorylation of the β-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution
16. Norepinephrine increases β-receptors and adenylate cyclase in canine myocardium
17. Chronic norepinephrine elicits desensitization by uncoupling the β-receptor
18. Effect of chemical sympathectomy on (-)-isoprenaline-induced changes in cardiac beta-adrenoceptor subtypes in the guinea-pig and rat
19. Effects of chronic β-adrenergic receptor stimulation in mice
20. Alterations in cardiac β-adrenoceptor responsiveness and adenylate cyclase system by congestive heart failure in dogs
21. β-Adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms
22. Abnormalities in sympathoneuronal regulation are localized to failing myocardium in rabbit heart
23. Differential changes in left and right ventricular adenylyl cyclase activities in congestive heart failure
24. Myocardial sympathetic denervation prevents chamber-specific alteration of β-adrenergic transmembrane signaling in heart failure
25. Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine
26. Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons
27. Species differences in aortic response to vasoactive amines: The effects of compound 48/80, cocaine, reserpine and 6-hydroxydopamine
28. A simplification of the protein assay method of Lowry et al. Which is more generally applicable
29. The attractions of proteins for small molecules and ions
30. Ligand: A versatile computerized approach for characterization of ligand-binding systems
31. CGP20712A: A useful tool for quantitating β1- and β2-adrenoceptors
32. Effect of palmitoyl carnitine in Na, K-ATPase and adenylate cyclase activity of canine myocardial sarcolemma
33. Dissociation between regional dysfunction and β-adrenergic receptor signaling in heart failure
34. Regulation of adrenergic receptor number following chronic noradrenaline infusion in the rabbit
35. Antioxidant vitamins attenuate norepinephrine-induced myocardial β-adrenoceptor down-regulation and subsensitivity
36. Cardiac sympathetic nervous activity in congestive heart failure
37. Decreased adrenergic neuronal uptake activity in experimental right heart failure
38. Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure
39. Evidence for reduction of norepinephrine uptake sites in the failing human heart
40. Mechanisms of β-adrenergic receptor regulation in cultured chick heart cells
41. Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alphal- and beta-adrenoceptors
42. Effects of pressure overload, left ventricular hypertrophy on β-adrenergic receptors, and responsiveness to catecholamines
43. Evidence for a physiological role of presynaptic α-adrenoceptors: Modulation of noradrenaline release in the pitched rabbit
44. Dual-tracer assessment of coupling between cardiac sympathetic neuronal function and downregulation of β-receptors during development of hypertensive heart failure of rats
45. Cardiac sympathetic neuronal function in left ventricular volume and pressure overload
46. Downregulation of myocardial β-adrenergic receptors: Receptor subtype selectivity
47. Role of cardiac nerves in desensitization