Study the mechanisms of U-50,488 to prevent the development of morphine tolerance in guinea pigs

Chinese Journal of Physiology

Volumn 43, Issue 4, 2000, Pages 179-184

  Tao, Pao Luh ^a   Wu, Shie Chung ^a   Yang, Chun Hua ^a   Wu, Chin Chen ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Glutamate; Morphine; N methyl D aspartate; Nitric oxide; Tolerance; U 50,488

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; GLUTAMIC ACID; MORPHINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CHRONICITY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RECEPTOR BINDING; GUINEA PIG; HOT PLATE TEST; MALE; MORPHINE TOLERANCE; NONHUMAN; SPINAL CORD;

EID: 0034526024     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Bhargava, H.N., Reddy, P.L. and Gudehithlu, K.P. Down-regulation of N-Methyl-D-aspartate (NMDA) receptors of brain regions and spinal cord of rats treated chronically with morphine. Gen. Pharmacol 26: 131-136, 1995.
2. Bredt, D.S. and Snyder, S.H. Nitric oxide, a novel neuronal messenger. Neuron 8: 3-11, 1992.
3. Gannon, R.L. and Terrian, D.M. U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals. Brain Res. 548: 242-247, 1991.
4. Garthwaite , J., Garthwaite, G., Plamer, R.M.J. and Moncada, S. NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur. J. Pharmacol. 172: 413-416, 1989.
5. Garthwaite, J. and Garthwaite, G. Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro. J. Neurochem. 48: 29-39, 1987.
6. 3 H] MK-801 to brain regions and spinal cord of the rat. Brain Res. 639: 269-274, 1994.
7. Hill M.P. and Brotchie, J.M. Modulation of glutamate release by a κ-opioid receptor agonist in rodent and primate striatum. Eur. J. Pharmacol. 281: R1-R2, 1995.
8. G -Nitro-L-arginine prevents morphine tolerance. Eur. J. Pharmacol. 221: 399-400, 1992.
9. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. Protein measurement with the Folin phenol reagents. J. Biol. Chem. 193: 265-268, 1951.
10. Lue, W.M., Su, M.T., Lin, W.B. and Tao, P.L. The role of nitric oxide in the development of morphine tolerance in the rat hippocampal slices. Eur. J. Pharmacol. 383: 129-135, 1999.
11. Majeed, N.H., Przewlocka, B., Machelska, H. and Przewlocka, R. Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice. Neuropharmacology 33: 189-192, 1994.
12. Marek, P., Ben-Eliyahu, S., Vaccarino, A.L. and Liebeskind, J.C. Delayed application of MK-801 attenuates development of morphine tolerance in rats. Brain Res. 558: 163-165, 1991.
13. + evoked glutamate release from rat cerebrocortical slices. Neurosci. Lett. 218: 79-82, 1996.
14. Su, M.T., Lin, W.B., Lue, W.M., Cheng, C.Y. and Tao, P.L. Blockade of the development of morphine tolerance by U-50,488, an AVP antagonist or MK-801 in the rat hippocampal slice. Br. J. Pharmacol. 123: 625-630, 1998.
15. Szmuszkovicz, J. 2-aminocycloaliphatic amide compounds. US Pat. 4,145,435. Chem. Abst. 91: 39003g, 1979.
16. Szmuszkovicz, J. and Von Voigtlander, P.F. Benzeneacetamide amines: structurally novel non-mu opioids. J. Med. Chem. 25: 1125-1126, 1982.
17. Takahashi, M., Senda, T. and Kaneto, H. Role of spinal κ opioid receptors in the blockade of the development of antinociceptive tolerance to morphine. Eur. J. Pharmacol. 200: 293-297, 1991.
18. Tao, P.-L., Hwang, C.-L. and Chen, C.-Y. U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs. Eur. J. Pharmacol. 256: 281-286, 1994.
19. Tiseo, P.J. and Inturrisi, C.E. Attenuation and reversal of morphine tolerance by the competitive N-Methyl-D-Aspartate receptor antagonist, LY274614. J. Pharmacol. Exp. Ther. 264: 1090-1096, 1993.
20. Trujillo, K.A. and Akil, H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 85-87, 1991.
21. Ueda, M., Sugimoto, K., Oyama, T., Kuraishi, Y. and Satoh, M. Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices. Neuropharmacology 34: 303-308, 1995.
22. Yamamoto, T., Ohno, M. and Ueki, S. A selective κ-opioid agonist, U-50,488H, blocks the development of tolerance to morphine analgesia in rats. Eur. J. Pharmacol. 156: 173-176, 1988.