Interleukin-2 enhances the growth of human melanoma cells derived from primary but not from metastatic tumours

European Cytokine Network

Volumn 11, Issue 4, 2000, Pages 654-661

  Garcia Vazquez M D ^a   Boyano, M D ^a   Canavate M L ^a   Gardeazabal, J ^a   De Galdeano, A G ^a   Lopez Michelena T ^a   Raton J A ^a   Izu, R ^a   Diaz Ramon J L ^a   Diaz Perez J L ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Growth factor; Human melanoma; Interleukin 2; Interleukin 2 receptor; Metastatic cells; Primary melanoma

Indexed keywords

BLOCKING ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ARTICLE; AUTOCRINE EFFECT; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GROWTH STIMULATION; HUMAN; HUMAN CELL; MELANOMA CELL; METASTASIS; PARACRINE SIGNALING; TUMOR GROWTH;

ANTIBODIES, MONOCLONAL; AUTOCRINE COMMUNICATION; CELL DIVISION; CULTURE MEDIA, CONDITIONED; HUMANS; INTERLEUKIN-2; MELANOMA; NEOPLASM METASTASIS; RECEPTORS, INTERLEUKIN-2; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

MURINAE;

EID: 0034525197     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Interleukin-2: Inception, impact, and implications
2. Biology of natural killer cells
3. The immunobiological effects of interleukin-2 in vivo
4. Cytokine therapy of malignant melanoma
5. Durability of complete responses in patients with metastatic cancer treatment with high-dose interleukin-2: Identification of the antigens mediating response
6. The IL-2/IL-2 receptor system: A current overview
7. The interleukin-2 receptor
8. Cloning of the γ chain of the human receptor
9. Interleukin-2 receptor γ chain: A functional component of the interleukin-7 receptor
10. Utilization of β and γ chains of IL-2 receptor by the novel cytokine IL-15
11. The IL-2 receptor γc-chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implications for the structure of the IL-4 receptor
12. B16F10 murine melanoma cells express interleukin-2 and a functional interleukin-2 receptor
13. IL-2 treatment of B16F10 melanoma cells stimulates metastatic colonization in the liver
14. The addition of interleukin-2 to cyclophosphamide therapy can facilitate tumor growth of B16 melanoma
15. Human melanoma cells express a functional interleukin-2 receptor
16. Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes
17. Human melanoma cell line M14 secretes a functional interleukin 2
18. Role of interleukin (IL)-2 and IL-15 in the tumour progression of a melanoma cell line MELP, derived from an IL-2 progressor patient
19. Serum-soluble IL-2 receptor and IL-6 in patients with melanoma
20. Expression of melanoma-associated antigens in rapidly dividing human melanocytes in culture
21. + peripheral blood T lymphocytes induced by an anti-CD4 monoclonal antibody
22. Trends in the safety of high dose bolus interleukin-2 administration in patients with metastatic cancer
23. Receptors for interleukin 2 on human squamous cell carcinoma cell lines and tumor in situ
24. Interleukin 2 receptor expression and interleukin 2 localisation in human solid tumors cells in situ and in vitro: Evidence for a direct role in the regulation of tumour cell proliferation
25. Expression of IL-2 receptors in human melanoma cells
26. Cytokine modulation of antigen expression in human melanoma cell lines derived from primary and metastatic tissues
27. The multi-subunit interleukin-2 receptor
28. Structural design and molecular evolution of a cytokine receptor superfamily
29. Heterodimerization of the interleukin-2 receptor β and γ chain cytoplasmic domains is required for signalling
30. Cytokine receptor expression by solid tumours
31. IL-2Rα on one cell can present IL-2 to IL-2Rβ/γc on another cell to augment IL-2 signaling
32. Growth factor independence and growth regulatory pathways in human melanoma development
33. Interleukin-6: A fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stage of tumor progression
34. IL-15 is produced by a subset of human melanomas, and is involved in the regulation of markers of melanoma progression through juxtacrine loops
35. Cytokine sensitivity of metastatic human melanoma cell lines-simultaneous inhibition of proliferation and enhancement of gelatinase activity
36. Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity
37. Neoplastic cells that express low levels of MHC class I determinants escape host immunity
38. Cyclosporin A upmodulates the α-subunit of the interleukin-2 receptor and the metastatic ability of murine B16F10 melanoma cells