Variation in inhibitor reactivity in acquired haemophilia A with different concentrates

Clinical and Laboratory Haematology

Volumn 22, Issue 5, 2000, Pages 287-290

  Sukhu, K ^a   Keeling, D M ^a   Giangrande, P L F ^a  

^a CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Acquired haemophilia; Factor VIII concentrates; Haemostasis; Inhibitor assay

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 8 CONCENTRATE; RECOMBINANT BLOOD CLOTTING FACTOR 8; VON WILLEBRAND FACTOR;

ARTICLE; ASSAY; AUTOIMMUNE DISEASE; BLEEDING DISORDER; CHEMICAL REACTION KINETICS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; HEMATOLOGIC DISEASE; HEMOPHILIA A; HEMOSTASIS; HUMAN; PREGNANCY; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ANTIBODIES; BLOOD COAGULATION TESTS; FACTOR VIII; HEMOPHILIA A; HUMANS; NEUTRALIZATION TESTS; REPRODUCIBILITY OF RESULTS;

EID: 0034524781     PISSN: 01419854     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2257.2000.00328.x     Document Type: Article

References (12)

1. A comparison of the Bethesda and new Oxford methods of factor VIII antibody assay
2. Variation in factor VIII inhibitor reactivity with different commercial factor VIII preparations
3. The mode of action of antibodies which destroy factor VIII. Antibodies which give complex concentration graphs
4. Acquired inhibitors
5. Localisation of human factor VIII inhibitor epitopes to two polypeptide fragments
6. A survey of 215 non-haemophilic patients with inhibitors to FVIII
7. Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors
8. The assay of factor VIII-related antigen by an immuno-enzymatic method
9. Phospholipid binding of factor VIII in different therapeutic concentrates
10. A mechanism for inhibition of FVIII binding to phospholipid by von Willebrand factor
11. Co-Localisation of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralisation
12. A factor VIII neutralising monoclonal antibody and a human inhibitor alloantibody recognising epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserine