Listeriolysin O-induced stimulation of mucin exocytosis in polarized intestinal mucin-secreting cells: Evidence for toxin recognition of membrane-associated lipids and subsequent toxin internalization through caveolae

Cellular Microbiology

Volumn 2, Issue 6, 2000, Pages 487-504

  Coconnier, Marie Hélène ^a   Lorrot, Mathie ^a   Barbat, Alain ^a   Laboisse, Christian ^a   Servin, Alain L ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN; CHOLESTEROL; CHOLESTEROL OXIDASE; GANGLIOSIDE; GLYCOLIPID; LISTERIOLYSIN; LISTERIOLYSIN O; MEMBRANE LIPID; MUCIN; RECEPTOR; TOXIN; UNCLASSIFIED DRUG;

ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; EXOCYTOSIS; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTERNALIZATION; MICROTUBULE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; RECEPTOR BINDING;

BACTERIAL TOXINS; CACO-2 CELLS; CAVEOLAE; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL POLARITY; CHOLESTEROL; EXOCYTOSIS; FLUORESCENT ANTIBODY TECHNIQUE; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; HUMANS; INTESTINAL MUCOSA; MEMBRANE LIPIDS; MICROSCOPY, ELECTRON; MICROTUBULES; MUCINS;

EID: 0034523543     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2000.00073.x     Document Type: Article

References (89)

1. Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin
2. A pore-forming toxin interacts with a GPI anchored protein and causes vacuolation of the endoplasmic reticulum
3. Mevilonin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent
4. Podocytosis of small molecules and ions by caveola
5. The caveola membrane system
6. Neurotensin and neuromedin N stimulate mucin output in the human goblet cell clone Cl. 16E: A neurotensin receptor-mediated event
7. pH-dependent perforation of macrophages phagosomes by listeriolysin O from Listeria monocytogenes
8. Pore-forming bacterial toxins
9. Early functional effects of Clostridium difficile toxin A on human colonocytes
10. T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains
11. The tyrosine kinase connection; how GPI anchored proteins activate T cells
12. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
13. Multivalent feedback regulation of HGM CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth
14. Functions of lipid rafts in biological membranes
15. Regulation of cholesterol synthesis in four colonic adenocarcinoma cell lines
16. Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: Evidence for glucosedependent negative regulation
17. Listeria monocytogenes stimulates mucus exocytosis in the cultured human polarized mucin-secreting intestinal cells through action of listeriolysin O
18. Listeriolysin O is essential for virulence of Listeria monocytogenes: Direct evidence obtained by gene complementation
19. The erythrocyte receptor for the channel-forming toxin aerolysin is a novel glycosylphosphatidylinositol-anchored protein
20. Molecular and genetic determinants involved in invasion of mammalian cells by Listeria monocytogenes
21. Lipid microdomains in cell surface membrane
22. Nocodazole, a microtubule-active drug, interferes with apical protein delivery in cultured intestinal epithelial cells (Caco-2)
23. Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol
24. Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in Caco-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum
25. Caveolin is present in intestinal cells: Role in cholesterol trafficking?
26. One hundred and twenty seven cultured human tumor cell lines producing tumors in nude mice
27. Signal transduction, packaging and secretion of mucins
28. Cholera toxin stimulates secretion of immunoreactive intestinal mucin
29. Calcium pump of the plasma membrane is localized in caveola
30. Localization of inositol 1,4,5,-trisphosphate receptor-like protein in plasmallemal caveola
31. Purification, characterization, and toxicity of the sulfhydrylactived hemolysin listeriolysin O from Listeria monocytogenes
32. Microtubular organization and its involvement in the biogenic pathways of plasma membrane proteins in Caco-2 intestinal epithelial cells
33. Cross-linking of plasmalemmal cholesterol in lymphocytes induces capping, membrane shedding, and endocytosis through coated pits
34. Caveola, DIGs, and dynamics of sphingolipid-cholesterol microdomains
35. Lipid domain structure of the plasma membrane revealed by patching of membrane components
36. Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane
37. Listeriolysin O: Cholesterol inhibits cytolysis but not binding to cellular membranes
38. Looking at lipid rafts?
39. Aggregation of lipids rafts accompanies signaling via the T cell antigen receptor
40. Cyclic AMP-induced mucin exocytosis is independent of Cl-movements in human colonic epithelial cells (HT29-Cl.16E)
41. Cholesterol is required for surface transport of influenza virus hemagglutinin
42. Cellular cholesterol efflux mediated by cyclodextrins
43. Regulation of mucin exocytosis from intestinal goblet cells
44. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
45. Interaction of earthworm hemolysin with lipid membranes requires sphingolipids
46. Interaction of cholera toxin with cloned human goblet cells in monolayer culture
47. Mechanism of cholera toxin action on a polarized human epithelial cell line: Role of vesicular traffic
48. Targeting of cholera toxin and E. coli heat labile toxin in polarized epithelia: Role of COOH-terminal KDEL
49. Transcytosis of cholera toxin subunits across model human intestinal epithelia
50. Membrane insertion: The strategy of toxins
51. Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells
52. Functionally different GPI proteins are organized in different domains on the neuronal surface
53. Sequestration of GPI-anchored proteins in caveola triggered cross-linking
54. The T84 human colonic adenocarcinoma cell line produces mucin in culture and releases it in response to various secretagogues
55. Regulated and unregulated pathways for MUC2 mucin secretion in human colonic LS 180 adenocarcinoma cells are distinct
56. Identification of the structural gene encoding the SH-activated hemolysin of Listeria monocytogenes: Listeriolysin O is homologous to streptolysin O and pneumolysin
57. Expression in Escherichia coil and sequence analysis of the listeriolysin O determinant of Listeria monocytogenes
58. Attenuated mutants of the intracellular bacterium Listeria monocytogenes obtained by single amino acid substitutions in listeriolysin O
59. Mucin exocytosis: A major target for Helicobacter pylori
60. Transcytosis of albumin in capillary endothelium
61. Thiolactivated cytolysins
62. Production and characterization of neutralizing and nonneutralizing monoclonal antibodies against listeriolysin O
63. Gastrointestinal mucus synthesis, secretion and function
64. Caveolins, a family of scaffolding proteins for organizing preassembled signalling complexes at the plasma membrane
65. Cytoskeleton of intestinal goblet cells: Role of microtubules in baseline secretion
66. Protein disulfide isomerase-mediated reduction of the A-subunit of cholera toxin in a human intestinal cell line
67. Filipin-dependent inhibition of cholera toxin: Evidence for toxin internalization and activation through caveola-like domains
68. Brefeldin A blocks the response of cultured cells to cholera toxin: Implications for intracellular trafficking in toxin action
69. Assembly mechanism of the oligomeric streptolysin O pore: The early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization
70. U0ltrastructural localization of gangliosides: GM1 is concentrated in caveola
71. Caveola and caveolins
72. Digging into caveolae
73. Regulated internalization of caveola
74. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
75. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells
76. Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositolanchored protein targeting to a glycolipid-enriched membrane fraction
77. Cholera-induced mucin secretion in rat small intestine: Lack of effect of cAMP, cycloheximide, VIP, and colchicine
78. Structure of a cholesterol-binding, thiol activated cytolysin and a model of its membrane form
79. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate
80. Caveolin, a protein component of caveola membrane coats
81. A simple immunofiltration assay for mucins secreted by a human colonic epithelial cell line
82. Signal transducing molecules and GPl-linked proteins form a caveolin-rich insoluble complex in MDCK cells
83. Filipinsensitive caveola mediated transport in endothelium: Reduced transcytosis, scavenger endocytosis and capillary permeability of selected macromolecules
84. Enteric bacterial toxins: Mechanisms of action and linkage to intestinal secretion
85. Functional rafts in cell membranes
86. Ligands internalized through coated and non-coated invaginations follow a common intracellular pathway
87. Ganglioside structure dictates signal transduction by cholera toxin and association with caveola-like membrane domains in polarized epithelia
88. Lysenin, a novel sphingomyelin-specific binding protein
89. Oligomerization of Vibrio cholerae cytolysin yields a pentameric pore and has a dual specificity for cholesterol and sphingolipids in the target membrane