The invasion protein InIB from Listeria monocytogenes activates PLC-γ1 downstream from PI 3-kinase

Cellular Microbiology

Volumn 2, Issue 6, 2000, Pages 465-476

  Bierne, Hélène ^a   Dramsi, Shaynoor ^a   Gratacap, Marie Pierre ^b   Randriamampita, Clotilde ^c   Carpenter, Graham ^d   Payrastre, Bernard ^b   Cossart, Pascale ^a  

^a INSTITUT PASTEUR   (France)

^b CHU PURPAN   (France)

^c Laboratoire d'Immunologie Cellulaire et Tissulaire CNRS URA 625   (France)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CALCIUM; INOSITOL 1,4,5 TRISPHOSPHATE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA1; PROTEIN INIB; PROTEIN P85; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBUNIT; GENE INACTIVATION; HUMAN; HUMAN CELL; INTERNALIZATION; LISTERIA MONOCYTOGENES; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BACTERIAL PROTEINS; CALCIUM; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; ISOENZYMES; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; MEMBRANE PROTEINS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; TUMOR CELLS, CULTURED; TYROSINE; VIRULENCE;

BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES; MAMMALIA;

EID: 0034523542     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2000.00069.x     Document Type: Article

References (52)

1. Activation of phospholipase C-γ by phosphatidylinositol 3,4,5-trisphosphate
2. Elevation of intracellular free calcium level in HEp-2 cells infected with enteropathogenic Escherichia coli
3. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides
4. Calcium-a life and death signal [news]
5. Sequential activation of phosphatidylinositol 3-kinase and phospholipase C-γ2 by the M-CSF receptor is necessary for differentiation signaling
6. InIB: An invasion protein of Listeria monocytogenes with a novel type of surface association
7. The InIB protein of Listeria monocytogenes is sufficient to promote entry into mammalian cells
8. The 213-amino-acid teucine-rich repeat region of the Listeria monocytogenes InIB protein is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling
9. 19-binding protein, is a receptor for the InLB invasion protein of Listeria monocytogenes
10. Phospholipase C-gamma as a signal-transducing element
11. Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: Bacterial factors, cellular ligands and signaling
12. Fc receptor-mediated phagocytosis occurs in macrophages at exceedingly IOw cytosolic Ca2+ levels
13. BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages
14. + response amplitude and duration
15. Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium
16. Intracellular pathogens and the act in cytoskeleton
17. Entry of L. monocytogenes into hepatocytes requires expression of InIB, a surface protein of the internalin multigene family
18. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting
19. A diarrheal pathogen, enteropathogenic Escherichia coli (EPEC), triggers a flux of inositol phosphates in infected epithelial cells
20. Receptor protein-tyrosine kinases and their signal transduction pathways
21. Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-γ2 is an early key event in FcγRIIA-mediated activation of human platelets
22. Signal transduction of phagocytosis
23. Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: InIB-dependent invasion, long-term intracellular growth, and spread from macrophages to endothelial cells
24. Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
25. Host-pathogen interactions during entry and actin-based movement of Listeria monocytogenes
26. A role for phosphoinositide 3-kinase in bacterial invasion
27. The Listeria monocytogenes protein InIB is an agonist of mammalian phosphoinositide 3-kinase
28. Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils
29. Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development
30. Association of the insulin receptor with phospholipase C-gamma (PLCγ) in 3T3-L1 adipocytes suggests a role for PLCγ in metabolic signaling by insulin
31. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
32. Significance of PIP2 hydrolysis and regulation Of phospholipase C isozymes
33. A novel function of InIB from Listeria monocytogenes: Activation of NF-kB in J774 macrophages
34. EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
35. Structure of the InIB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes
36. Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
37. The epidermal growth factor-induced calcium signal in A431 cells
38. Internalin B is essential for adhesion and mediates the invasion of Listeria monocytogenes into human endothelial cells
39. Phosphoinositide 3-kinase regulates phospholipase Cγ-mediated calcium signaling
40. Divergent regulation of phosphatidylinositol 3-kinase P85α and P85β isoforms upon T cell activation
41. Regulation of phosphoinositide-specific phospholipase C isozymes
42. Salmonella typhimudum induces an inositol phosphate flux in infected epithelial cells
43. PtdIns-3,4,5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
44. Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle
45. The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism
46. Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium
47. Phagocytosis by zippers and triggers
48. Cloning and expression of the Listeria monocytogenes haemolysin in E. coli
49. Listeria monocytogenes phospholipase C-dependent calcium signaling modulates bacterial entry into J774 macrophage-like cells
50. Killing of phagocytosed Staphylococcus aureus by human neutrophils requires intracellular free calcium
51. Dissociation of tyrosine phosphorylation and activation of phosphoinositide phospholipase C induced by the protein kinase C inhibitor Ro-31-8220 in Swiss 3T3 cells treated with platelet-derived growth factor
52. Cytosolic free calcium is essential for immunoglobulin G-stimulated intracellular killing of Staphylococcus aureus by human monocytes