Synthesis and calcium antagonistic activity of 2,6,6-trimethyl-3-carbomethoxy(ethoxy)-4-aryl-1,4,5,6,7,8-hexahydroquinoline derivatives

Farmaco

Volumn 55, Issue 11-12, 2000, Pages 665-668

  Rahime, Şimek ^a   Burcinsmailolu U ^a   Şafak, Cihat ^a   Sahin Erdemli, Nci ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

1,4 Dihydropyridine; Calcium antagonistic activity; Hexahydroquinoline; Pharmacology; Spectra

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; CALCIUM ANTAGONIST; NIFEDIPINE; QUINOLINE DERIVATIVE;

ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM ANTAGONISM; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA, THORACIC; CALCIUM CHANNEL BLOCKERS; DIHYDROPYRIDINES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; QUINOLINES; RATS; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 0034523222     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(00)00086-0     Document Type: Article

References (14)

1. 2+ channel antagonists
2. Hantzsch-type dihydropyridine hypotensive agents 3
3. Synthesis smooth muscle calcium channel effects of dialkyl 1,4-dihydro-2,6-dimethyl-4-aryl-3,5-pyridinedicarboxylates containing a nitrone moiety in the 4-aryl substituent
4. The enantiomers of the dihydropyridine derivative H 160/51 show opposite effects of stimulation and inhibition
5. Synthesis, configuration, and calcium modulatory properties of enantiomerically pure 5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates
6. Synthesis and crystal structure of optically active 2-(benzyl(phenyl)amino(ethyl(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl) -1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate (NZ-105)
7. 3-Acetyl-5-aryl-3-oxo-2,7,7-trimethyl-1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium antagonistic activities
8. Synthesis of some 1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium antagonistic activity
9. 2-Methyl-3-acetyl-4-aryl-5-oxoindeno[1,2-b]pyridine derivatives and their calcium antagonistic activities
10. Affects of bepridil compared with calcium antagonists on rat and rabbit aorta
11. Negative ion mass spectrometry of dihydropyridine
12. Studies on nilvadipine I. Synthesis and structure-activity relationships of 1,4-dihydropyridines containing novel substituents at the 2-position
13. Structure-activity studies on nifedipine in isolated cardiac muscle
14. Structural studies of a new dihydropyridine calcium channel antogonist, nilvadipine