Enantioselective synthesis of (s)-ibuprofen ester prodrug in cyclohexane by Candida rugosa lipase immobilized on Accurel MP1000

Biotechnology Progress

Volumn 16, Issue 6, 2000, Pages 986-992

  Chen, J C ^a   Tsai, S W ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALICYCLIC COMPOUND; BATCH REACTOR; CULTURE MEDIUM; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; ESTERIFICATION KINETICS; FUNGAL ENZYME; KINETIC MODEL; PACKED BED REACTOR; PRODRUG; THERMOSTABILITY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CANDIDA; CYCLOHEXANES; ENZYMES, IMMOBILIZED; ESTERS; IBUPROFEN; KINETICS; LIPASE; PRODRUGS; SUBSTRATE SPECIFICITY; TEMPERATURE;

CANDIDA RUGOSA;

EID: 0034521368     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0000961     Document Type: Article

References (22)

1. Naproxen 1-alkylazacycloalkan-2-one esters as dermal prodrugs: In vitro evaluation
2. A facile enzymatic process for the preparation of (S)-Naproxen ester prodrug in organic solvents
3. Lipase-catalyzed enantioselective esterification of ibuprofen in organic solvents under controlled water activity
4. Enzymatic resolution of racemic ibuprofen by surfactant-coated lipase in organic media
5. Thermodynamic predictions for biocatalysis in nonconventional media: Theory, tests, and recommendations for experimental design and analysis
6. Predictions the behavior of lipases in low-water media
7. The importance of stereochemistry in the clinical pharmacokinetics of the 2-arylpropionic acid nonsteroidal anti-inflammatory drugs
8. Enzymatic resolution of racemic ibuprofen esters; Effects of organic cosolvents and temperature
9. Enantioselective esterification of 2-arylpropionic acids catalyzed by immobilized Rhizomucor Miehei lipase
10. Use of lipases in the resolution of racemic ibuprofen
11. Activity of Pseudomonas cepacia lipase in organic media is greatly enhanced after immobilization on a polypropylene support
12. Pharmacokinetic analysis of diethyl carbonate prodrugs of ibuprofen and naproxen
13. Ester and amide prodrugs of ibuprofen and naproxen: Synthesis, antiinflammatory activity, and gastrointestinal toxicity
14. Resolution of ibuprofen catalyzed with free and immobilized lipases
15. Synthesis and evaluation of morpholinoalkyl ester prodrugs of indomethacin and naproxen
16. Scale-up of the enantioselective reaction for the enzymatic resolution of (R,S)-ibuprofen
17. Enzymatic synthesis of (S)-ibuprofen ester prodrug from racemic ibuprofen by lipase in organic solvents
18. Ester des Naproxen als potentielle prodrogs zur hautpenetration, 1. Mitt. Synthese und physikochemisch eigenschaften
19. Ester des Naproxen als potentielle prodrugs zur hautpenetration, 2. Mitt.: Penetrationseigenschaften an exzidierter Maeusehaut
20. Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: Racemization of (R)-ibuprofen and chemical hydrolysis of (S)-ester formed
21. Skin permeability of various nonsteroidal anti-inflammatory drugs in man