Acadesine and intestinal barrier function after hemorrhagic shock and resuscitation

Critical Care Medicine

Volumn 28, Issue 12, 2000, Pages 3876-3884

  Ragsdale, D N ^a   Proctor, K G ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Adenosine; Blood flow; Dextrans; High pressure liquid chromatography; Histology; Ileum; Laser Doppler; Mucosa; Trauma

Indexed keywords

4 AMINO 3 BROMOPYRAZOLO[3,4 D]PYRIMIDINE 1 (5 AMINO 5 DEOXYRIBOSIDE); 5 AMINO 4 IMIDAZOLECARBOXAMIDE; ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HEMORRHAGIC SHOCK; ILEUM; INTESTINE BLOOD FLOW; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESUSCITATION; SWINE;

EID: 0034521009     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200012000-00023     Document Type: Article

References (43)

1. Role of the gut in multiple organ failure: Bacterial translocation and permeability changes
2. Bacterial translocation in multiple organ failure: Cause or epiphenomenon still unproven
3. Multiple-organ failure. Generalized autodestructive inflammation?
4. The gut origin septic states in blunt multiple trauma (ISS = 40) in the ICU
5. The effects of ischemia and ischemia-reperfusion on bacterial translocation, lipid peroxidation, and gut histology: Studies on hemorrhagic shock in pigs
6. Gut bacterial translocation via the portal vein: A clinical perspective with major torso trauma
7. Bacterial translocation in trauma patients
8. Intestinal cytokine response after gut ischemia: Role of gut barrier failure
9. Interleukin-6 and tumor necrosis factor production in an enterocyte cell model (Caco-2) during exposure to Escherichia coli
10. The gut: A cytokine-generating organ in systemic inflammation?
11. Gastrointestinal mucosal injuries in experimental models of shock, trauma, and sepsis
12. Attenuation of no-reflow phenomenon, neutrophil activation, and reperfusion injury in intestinal microcirculation by topical adenosine
13. Ischemia-reperfusion injury: Role of oxygen-derived free radicals
14. Bacterial translocation occurs in humans after traumatic injury: Evidence using immunofluoresence
15. Endotoxemia and bacteremia during hemorrhagic shock. The link between trauma and sepsis?
16. Lisofylline ameliorates intestinal mucosal barrier dysfunction caused by ischemia and ischemia/reperfusion
17. Mucosal permeability after subclinical intestinal ischemia-reperfusion injury: An exploration of possible mechanisms
18. Adenosine, an endogenous anti-inflammatory agent
19. Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine
20. Actions of adenosine on nitro-blue tetrazolium deposition and surface pH during intestinal reperfusion injury
21. Acadesine: The prototype adenosine regulating agent for reducing myocardial ischemic injury
22. Protective effect of an adenosine kinase inhibitor in septic shock
23. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins
24. Anti-inflammatory effects of an adenosine kinase inhibitor. Decreased neutrophil accumulation and vascular leakage
25. Resuscitation of hemorrhagic shock with hypertonic saline/dextran or lactated Ringer's supplemented with AICA riboside
26. Acadesine and lipopolysaccharide-evoked pulmonary dysfunction after resuscitation from traumatic shock
27. Acadesine during fluid resuscitation from shock and abdominal sepsis
28. Endogenous adenosine and secondary injury after chest trauma
29. Combination therapy that targets secondary pulmonary changes after abdominal trauma
30. Passage of molecules through the wall of the gastrointestinal tract. I. A simple experimental model
31. Transient inhibition of CD18-dependent leukocyte functions after hemorrhage and polymicrobial sepsis
32. Resuscitation of conscious pigs following hemorrhage: Comparative efficacy of smallvolume resuscitation
33. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal
34. Measurement of the release of adenine nucleotides during platelet aggregation by small-bore-column isocratic high-performance liquid chromatography
35. Determination of the ultraviolet and radioactivity of purine compounds separated by highperformance liquid chromatography
36. Role of endothelium-derived nitric oxide and adenosine in functional myocardial hyperemia
37. Protective effect of preconditioning on the injury associated to hepatic ischemia-reperfusion in the rat: Role of nitric oxide and adenosine
38. Adenosine relaxation of isolated vascular smooth muscle
39. Extracellular adenosine and the local control of intestinal blood flow
40. Local modulation of adrenergic neurotransmission in blood vessels
41. Inhibition of sympathetic neurotransmission in canine blood vessels by adenosine and adenine nucleotides
42. AICA-riboside: Safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent
43. Granulocyte-colony stimulating factor improves host defense to resuscitated shock and polymicrobial sepsis without provoking generalized neutrophil-mediated damage