C677T mutation in the methylene tetrahydrofolate reductase gene as a risk factor for venous thrombotic disease in Austrian patients

Thrombosis Research

Volumn 100, Issue 5, 2000, Pages 405-407

  Seinost, Gerald ^a   Renner, Wilfried ^a   Brodmann, Marianne ^a   Winkler, Monika ^a   Köppel, Herwig ^a   Pilger, Ernst ^a  

^a UNIVERSITY HOSPITAL GRAZ   (Austria)

Author keywords

C677T gene polymorphism; Homocysteine; MTHFR; Thrombosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADULT; AGED; ARTICLE; AUSTRIA; DNA POLYMORPHISM; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; VEIN THROMBOSIS;

ADULT; AGED; ALLELES; AUSTRIA; FEMALE; GENE FREQUENCY; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; RISK FACTORS; VENOUS THROMBOSIS;

EID: 0034519760     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00341-8     Document Type: Article

References (9)

1. Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial disease
2. Hyperhomocysteinemia: An independent risk factor for vascular disease
3. Meta-Analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease
4. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
5. Prevalence of the 677C to T mutation in the methylenetetrahydrofolate reductase gene in Italian patients with venous thrombotic disease
6. The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase (MTHFR) gene and risk of venous thromboembolism
7. The mutation Ala677 → Val in the methylene-tetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
8. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism
9. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase