Nitric oxide synthase and heme oxygenase knockout mice—what have we learned?

International Journal of Impotence Research

Volumn 12, Issue , 2000, Pages S42-S44

  Burnett, A L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; HEME OXYGENASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

CONFERENCE PAPER; EJACULATION; KNOCKOUT MOUSE; MOUSE; MUSCLE REFLEX; NEUROTRANSMISSION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; REGULATORY MECHANISM; SEXUAL FUNCTION; VASCULAR ENDOTHELIUM;

ANIMALS; HEME OXYGENASE (DECYCLIZING); MICE; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE; SEX;

EID: 0034518866     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3900560     Document Type: Article

References (22)

1. Burnett AL. Role of nitric oxide in the physiology of erection. Biol Reprod 1995; 52: 485-489.
2. Burnett AL. Nitric oxide in the penis: physiology and pathology. J Urol 1997; 157: 320-324.
3. Gonzalez-Cadavid NF, Rajfer J. Nitric oxide and other neurotransmitters of the corpus cavernosurn. In: Hellstrom WJG (ed). Textbook of Andrology: Relevant Issues in Male Infertility and Sexual Dysfunction. Springer: New York, 1997, pp 425-439.
4. Giuliano F et al. Stimulation of the medial preoptic area of the hypothalamus in the rat elicits increases in intracavernosal pressure. Neurosci Lett 1996; 209: 1-4.
5. Melis MR, Succu S, Iannucci U, Argiolas A. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regulat Pept 1999; 69: 103-111.
6. Burnett AL et al. Localization of nitric oxide synthase in spinal nuclei innervating pelvic ganglia. J Urol 1995; 153: 212-217.
7. Vanhatalo S, Klinge E, Sjostrand NO, Soinila S. Nitric oxide-synthesizing neurons originating at several different levels innervate rat penis. Neuroscience 1996; 75: 891-899.
8. Han M et al. Evidence for carbon monoxide (CO) in the male rat genitourinary tract: a new mediator? J Urol 1996; 155: 549A.
9. Burnett AL et al. Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Nature Med 1998; 4: 84-87.
10. Huang PL et al. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 1993; 75: 1273-1286.
11. Huang PL et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995; 377: 239-242.
12. Poss KD et al. Hippocampal long-term potentiation is normal in heme oxygenase-2 mutantmice. Neuron 1995; 15: 867-873.
13. Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I. A nitric oxide-like factor mediates non-adrenergic non-cholinergic neurogenic relaxation of penle corpus cavernosuin smooth muscle. J Clin Invest 1991: 88: 112-118.
14. Burnett AL et al. Nitric oxide: a physiologic mediator of penile erection. Science 1992; 257: 401-403.
15. Rajfer J et al. Nitric oxide as a mediator of relaxation of the corpus cavernosuin in response to nonadrenergic, noncholi-nergic neurotransmission. New Engl J Med 1992; 362: 90-94.
16. Burnett AL et al. Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase. Mol Med 1996; 2: 288-296.
17. Brenman JE et al. Regulation of neuronal nitric oxide synthase through alternative transcripts. Dev Neurosci 1997; 19: 224-231.
18. Eliasson MJL, Blackshaw S, Schell MJ, Snyder SH. Neuronal nitric oxide synthase alternatively spliced forms: prominent functional localizations in the brain. Proc Natl Acad Sci USA 1997; 94: 3396-3401.
19. Burnett AL et al. Neuronal nitric oxide synthase (nNOS) gene variants: genitourinary localizations and functional evidence for compensatory nNOS-dependent penile erection in nNOS-alpha-deficient transgenic mice. J Urol 1998; 159: 89A.
20. Gonzalez-Cadavid NF, Magee T, Vernet D, Gitter J, Smith N, Rajfer J, Zeller CB, Burnett AL. Expression of penile neuronal nitric oxide synthase (PnNOS) in the rat and mouse penile nerves. J Urol1999; 161: 219.
21. Kriegsfeld LJ et al. Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-J-). Physiol Behav 1999; 67: 561-566.
22. Cellik S, Moncada S. Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: a comparison with other species. Proc Natl Acad Sci USA 1997; 94: 8226-8231.