New analogues of camptothecins: Activity and resistance

Annals of the New York Academy of Sciences

Volumn 922, Issue , 2000, Pages 175-177

  Boven, Epie ^a   Van Hattum, Annemarie H ^a   Hoogsteen, Ilse ^a   Schlüper, Hennie M M ^a   Pinedo, H M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 [(2 TRIMETHYLSILYL)ETHYL]CAMPTOTHECIN; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CISPLATIN; EXATECAN; KARENITECIN; TOPOTECAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; CANCER CELL CULTURE; CANCER RESISTANCE; COLON CANCER; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; OVARY CANCER; R FACTOR; TREATMENT OUTCOME; TUMOR XENOGRAFT;

ANIMALIA;

EID: 0034515311     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb07035.x     Document Type: Conference Paper

References (7)

1. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo
2. Karenitecins (PART II): A novel class of orally active highly lipophilic topoisomerase inhibitors
3. Potentiation of azidothymidine cytotoxicity in cisplatin-resistant human ovarian carcinoma cells
4. CPT-11 sensitivity in relation to the expression of p170-glycoprotein and multidrug resistance-associated protein
5. Anti-tumor activity of CPT-11 in experimental human ovarian cancer and soft-tissue sarcoma
6. Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells
7. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line