The effect of humoral immunity against adducted benzo[a]pyrene on DNA damage elicited by acute carcinogen exposure in Swiss mice

In Vivo

Volumn 14, Issue 6, 2000, Pages 747-751

  Galati, R ^a   Crebelli, R ^a   Zijno, A ^a   Conti, L ^a   Falasca, G ^a   Verdina, A ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

DNA adducts; ELISA; Host factor; Specific immunity

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN; CELL DNA; IMMUNOGLOBULIN G;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL ISOLATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; DNA DAMAGE; DOSE RESPONSE; ERYTHROCYTE; ERYTHROCYTE COUNT; EXPOSURE; HUMORAL IMMUNITY; IMMUNIZATION; LIVER CELL; MODULATION; MOUSE; NONHUMAN;

EID: 0034515047     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Relationships between DNA adduct formation and carcinogenesis
2. Multistage and multifactorial nature of carcinogenesis
3. Formation and persistence of DNA adducts in different target tissues of rats after multiple administration of benzo[a]pyrene
4. Formation and persistence of novel benzo[a]pyrene adducts in rat lung, liver and peripheral blood lymphocyte DNA
5. DNA adducts in human carcinogenesis: Etiological relevance and structure-activity relationships
6. Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time integrated DNA adduct levels
7. Heterogeneity of DNA repair: Implications for human disease and oncology
8. Cancer-Prone human disorders with defects in DNA repair
9. Drug metabolism polymorphisms as modulators of cancer susceptibility
10. Immunoprophylactic intervention in chemical toxicity and carcinogenicity
11. Reduction of intestinal carcinogen absorption by carcinogen-specific secretory immunity
12. Peroral administration of specific antibody enhances carcinogen excretion
13. Modulation of DNA binding in vivo by specific humoral immunological Response: A novel host factor in environmental carcinogenesis
14. Induction of humoral immunity toward 2-acetylaminofluorene in mice: Modulation of DNA binding after weeks dietary exposure to the carcinogen
15. Effects of specific humoral immunity on DNA-adduct formation in Swiss mice treated with benzo[a]pyrene
16. Identification of optimal conditions for the detection of benzo[a]pyrene-DNA adducts by enzyme-linked immunoadsorbent assay (ELISA)
17. Monoclonal antibodies to DNA modified by 8-methoxypsoralen and ultraviolet light
18. Increased sensitivity for determination of polycyclic aromatic hydrocarbon-DNA adducts in human DNA samples by dissociation-enhanced Lanthanide Fluoroimmunoassay (DELFIA)
19. Production of the antibodies against the coenzyme pyrrolequinoline quinone
20. Statistical analysis of in vivo cytogenetic assays
21. Antibodies to carcinogen-DNA adducts in mice chronically exposed to polycyclic aromatic hydrocarbons
22. Detection of benzo[a]pyrene diolepoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers
23. Determination of polycyclic aromatic hydrocarbons in the urine, benzo[a]pyrene diol epoxide-DNA adducts in lymphocyte DNA and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycylic aromatic hydrocarbons in the work atmosphere
24. Detection and characterization of human serum antibodies to polycyclic aromatic hydrocarbon diolepoxide DNA adducts
25. International Programme on Chemical Safety. Bone-marrow micronucleus test in Swiss male mice
26. Demonstration of Benzo[a]pyrene induced DNA damage in mice by alkaline single cell gel electrophoresis: Evidence for strand breaks in liver but not in lymphocytes and bone marrow
27. Intracellular lipoproteins as carriers for 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo[a]pyrene in rat and mouse liver
28. Detection and characterization of a novel hepatic 8 S binding protein for benzo[a]pyrene distinct from the Ah receptor
29. Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair
30. Individual differences in cancer susceptibility