Remacemide hydrochloride: A placebo-controlled, one month, double-blind assessment of its safety, tolerability and pharmakinetics as adjunctive therapy in patients with epilepsy

Seizure

Volumn 9, Issue 8, 2000, Pages 544-550

  Chadwick, D ^a   Smith, D ^a   Crawford, P ^b   Harrison, B ^c  

^a WALTON CENTRE FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^b YORK HOSPITAL   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Add on therapy; Antiepileptic drugs; Clinical trials; Epilepsy; Pharmacokinetics; Remacemide

Indexed keywords

1 METHYL 1,2 DIPHENYLETHYLAMINE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; DRUG METABOLITE; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; PRIMIDONE; REMACEMIDE; VALPROIC ACID; VIGABATRIN;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIPLOPIA; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; EPILEPSY; FEMALE; HUMAN; LABORATORY TEST; MALE; MEASUREMENT; NEUROPSYCHOLOGICAL TEST; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEIZURE; STEADY STATE; VERTIGO;

EID: 0034511335     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1053/seiz.2000.0448     Document Type: Article

References (6)

1. Classification of compounds for prevention of NMDLA-induced seizures/mortality, or maximal electroshock and pentylenetetrazol seizures in mice and antagonism of MK801 binding in vitro
2. Preclinical and clinical aspects of remacemide hydrochloride
3. A double-blind placebo controlled cross-over study of remacemide hydrochloride as adjunctive therapy in patients with refractory epilepsy
4. Mutual interaction between remacemide hydrochloride and carbamazepine: Two drugs with active metabolites
5. Mutual interaction between remacemide hydrochloride and phenytoin
6. A Friedman-type rank test for main effects in a two-factor ANOVA