The control of matrix metalloproteinase-2 expression in normal and keratoconic corneal keratocyte cultures

European Journal of Ophthalmology

Volumn 10, Issue 4, 2000, Pages 276-285

  Parkin, B T ^a   Smith, V A ^a   Easty, D L ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Corneal keratocytes; Gelatinases; Keratoconus; Metalloproteinases; Platelet derived growth factor (PDGF); Transforming growth factor (TGF )

Indexed keywords

COLLAGEN TYPE 4; GELATINASE A; GROWTH FACTOR; MATRIX METALLOPROTEINASE; PLATELET DERIVED GROWTH FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA; TRITIUM;

ARTICLE; CONTROLLED STUDY; CORNEA CELL; CORNEA DISEASE; HUMAN; HUMAN CELL; KERATOCONUS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TISSUE CULTURE;

EID: 0034501182     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.1177/112067210001000402     Document Type: Article

References (37)

1. Electron microscopic study of the pathology of keratoconus. Part 1
2. Characterization of the major matrix degrading metalloproteinase of human corneal stroma. Evidence for an enzyme/inhibitor complex
3. Over-expression of a Gelatinase A activity in keratoconus
4. Altered gelatinolytic activities in an apparent unilateral keratoconus patient. A case report
5. Increased collagenase and gelatinase activities in keratoconus
6. Increase in type I and type IV collagenolytic activity in primary cultures of keratoconus cornea
7. Keratoconus corneas: Increased gelatinolytic activity appears after modification of inhibitors
8. Collagenolytic/gelatinolytic metalloproteinases in normal and keratoconus corneas
9. Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases
10. Substrate specificies and activation mechanisms of matrix metalloproteinases
11. Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site
12. Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2
13. Human 72 kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2
14. Platelet-derived growth factor: Receptor expression in corneas and effects on corneal cells
15. Effect of PDGF, IL-1 α and BMP 2/4 on corneal fibroblast chemotaxis: Expression of the Platelet-Derived Growth Factor system in the cornea
16. Effects of platelet-derived growth factor on endothelial wound healing of human corneas
17. Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells
18. Platelet-derived growth factors-AA and -BB regulate collagen and collagenase gene expression differentially in human fibroblasts
19. Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor
20. Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors of metalloproteinases-1, -2 and -3 in rabbit aortic smooth muscle cells
21. Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea
22. Transforming growth factor-beta1 up-regulates type IV collagenase expression in cultured human keratinocyte
23. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor beta 1 in human fibroblasts: Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression
24. Transforming growth factor-beta and interleukin-1 modulate metalloproteinase expression by corneal stromal cells
25. A corneal epithelial inhibitor of stromal cell collagenase synthesis identified as TGF-beta 2
26. Unique regulation of the matrix metalloproteinase, gelatinase B
27. Matrix metalloproteinases in periodontal tissue remodelling
28. Effects of growth factors on corneal wound healing
29. Localization of transforming growth factor beta 1 mRNA in colorectal neoplasia: Correlation with antigen expression of gelatinase and tissue inhibitors of metalloproteinase
30. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor
31. Inhibition of corneal fibrosis by topical application of blocking antibodies to TGF(beta) in the rabbit
32. Reorganisation of polymerised actin: A possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels
33. Acid mucopolysaccharides and glycoproteins in the human cornea in relationship to age and keratoconus
34. Heterogeneity in keratoconus: Possible biochemical basis
35. Keratoconus: I. Biochemical studies
36. Effect of topically administered platelet-derived growth factor on corneal wound strength