Involvement of insulin-like growth factor-I in psoriasis as a paracrine growth factor: Dermal fibroblasts play a regulatory role in developing psoriatic lesions

Archives of Dermatological Research

Volumn 292, Issue 12, 2000, Pages 590-597

  Miura, H ^a   Sano, S ^a   Higashiyama, M ^a   Yoshikawa, K ^a   Itami, S ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytokine; Dermal fibroblast; IGF binding protein; Insulin like growth factor I; Psoriasis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; DOWN REGULATION; EPIDERMIS HYPERPLASIA; HUMAN; HUMAN CELL; PARACRINE SIGNALING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PSORIASIS; QUANTITATIVE ASSAY; REGULATORY MECHANISM; SKIN FIBROBLAST;

ADOLESCENT; ADULT; CELL CULTURE TECHNIQUES; CYTOKINES; FEMALE; FIBROBLASTS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PARACRINE COMMUNICATION; PSORIASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0034496171     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004030000188     Document Type: Article

References (40)

1. Psoriasis
2. + macrophages into the epidermis
3. The pathomechanims of psoriasis: The skin immune system and cyclosporin
4. The mechanisms of action of cyclosporin A in the treatment of psoriasis
5. Serial cultivation of epidermal keratinocytes from psoriasis plaques
6. Increased synergistic effect of EGF and IGF-I on DNA synthesis of cultured psoriatic keratinocytes
7. Effect of insulin-like growth factor-I/somatomedin C on thymidine incorporation in cultured psoriatic keratinocytes after growth arrest in growth factor-free medium
8. Transplantation of psoriatic skin onto nude mice
9. Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro
10. Experimental models for psoriasis
11. Localization of messenger ribonucleic acid for insulin-like growth factor-binding proteins in human skin by in situ hybridization
12. Modifications of insulin-like growth factor binding proteins and their role in controlling IGF actions
13. In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors
14. Prior chronic sun exposure decrease the lifespan of human skin fibroblasts in vitro
15. Interferon in suction blister fluid psoriatic lesions
16. Correlated increases of tumor necrosis factor, interleukin-6 and granulocyte monocyte-colony stimulating factor levels in suction blister fluids and sera of psoriatic patients - Relationship with disease severity
17. Psoriasis and alpha-interferon
18. Psoriasis induced by interferon-α
19. Psoriatic fibroblasts secrete lower amounts of IL-6 than healthy fibroblasts before and after stimulation with TNF-α
20. Interleukin-11 therapy selectively downregulates type I cytokines proinflammatory pathways in psoriasis lesions
21. Cytokines in psoriasis
22. A keratinocyte cell line synthesizes a predominant insulin-like growth factor-binding protein (IGFBP-3) that modulates insulin-like growth factor-1 action
23. Expression of insulin-like growth factor binding protein (IGFBP-3) in the psoriatic lesion
24. IGF binding proteins: Gene structure and expression
25. Mice carrying null mutations of the genes encoding insulin-like growth factor-I (IGF-I) and type I IGF receptor (IGFIr)
26. The insulin-like growth factor I receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptor
27. The insulin-like growth factor I receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: Correlation of increased expression with epidermal hyperplasia
28. Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides
29. MAP kinase abnormalities in hyperproliferative cultured fibroblasts from psoriatic skin
30. Regulation and characterization of the interferon-alpha present in patients with advanced human immunodeficiency virus type 1 disease
31. Acquired immunodeficiency syndrome-associated psoriasis and Reiter's syndrome
32. The cytokine network in psoriasis
33. Serum levels of interferons and TNF-α are not correlated to psoriasis activity and therapy
34. Systemic TNF administration in psoriatic patients: A promising therapeutic modality for severe psoriasis
35. Response to tumor necrosis factor in two cases of psoriasis
36. Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture
37. The insulin-like growth factors
38. IGF binding proteins: Regulators of cellular actions
39. Binding of insulin-like growth factor (IGF)-binding protein-5 to smooth-muscle cell extracellular matrix is a major determinant of the cellular response to IGF-I
40. Extracellular matrix contains insulin-like growth factor binding protein-5: Potentiation of the effects of IGF-I