Pathogenesis of nerve damage in leprosy: Genetic polymorphism regulates the production of TNFα

Leprosy Review

Volumn 71, Issue SUPPL., 2000, Pages

  Sarno, E N ^a   Santos, A R ^a   Jardim, M R ^a   Suffys, P N ^a   Almeida, A S ^a   Nery, J A C ^a   Vieira, L M M ^a   Sampaio, E P ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR 1; TUMOR NECROSIS FACTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

CELLULAR IMMUNITY; CONFERENCE PAPER; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; LEPROSY; MAJOR CLINICAL STUDY; MYCOBACTERIUM LEPRAE; NERVE INJURY; PATHOGENESIS; REACTION ANALYSIS;

EID: 0034496050     PISSN: 03057518     EISSN: None     Source Type: Journal    
DOI: 10.5935/0305-7518.20000087     Document Type: Conference Paper

References (19)

1. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
2. The role of tumor necrosis factor in health and disease
3. Variation in the TNFα promoter region associated with susceptibility to cerebral malaria
4. Effects of a tumor necrosis factor (TNF-alpha) promoter base transition on transcriptional activity
5. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-α gene promoter
6. Effects of a polymorphism in the human tumour necrosis factor α promoter on transcriptional activation
7. An allelic polymorphism within the human tumor necrosis factor α promoter region is strongly associated with HLA A1, B8 and DR3 alleles
8. Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis
9. Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease
10. Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy
11. Serum tumor necrosis factor and interleukin 1 in leprosy and during lepra reactions
12. Serum levels of tumor necrosis factor-alpha and interleukin-1β during leprosy reactional states
13. Tumor necrosis factor-alpha (TNFα) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactions
14. Role of inflammatory cytokines in tissue injury in leprosy
15. Cytokines, signal transduction, and inflammatory demyelination: Review and hypothesis
16. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
17. Classification of leprosy according to immunity: A five group system
18. Tumor necrosis factor promotor polymorphism (TNF2) seems to protect against development of severe forms of leprosy in a pilot study in Brazilian patients
19. TNFα and TGFβ act synergistically to kill Schwann cells