Dexamethasone enhances P-selectin mRNA expression in hyperoxic rat lungs

Inflammation Research

Volumn 49, Issue 12, 2000, Pages 655-665

  Ramsay, P L ^a   Piedboeuf, B ^b   Gamache, M ^b   Geske, R S ^a   Smith, C V ^a   Welty, S E ^c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b LAVAL UNIVERSITY   (Canada)

^c THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Animal model; Dexamethasone; Hyperoxic lung injury; Lung inflammation; P selectin

Indexed keywords

DEXAMETHASONE; HYBRID PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; PADGEM PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG MECHANISM; HISTOPATHOLOGY; HYBRIDIZATION; HYPEROXIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG INJURY; LUNG WEIGHT; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BACTERIAL TOXINS; BODY WEIGHT; DEXAMETHASONE; ENDOTOXINS; HEMOGLOBINS; HYPEROXIA; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIPOPOLYSACCHARIDES; LUNG; MALE; ORGAN SIZE; P-SELECTIN; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0034495244     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050643     Document Type: Article

References (45)

1. Morphologic changes in pulmonary oxygen toxicity
2. Morphologic aspects of the protection by endotoxin against acute and chronic oxygen induced lung injury in adult rats
3. Anoxia-reoxygenation-induced, neutrophil-mediated endothelial cell injury: Role of elastase
4. Superoxide production of human polymorphonuclear leukocytes stimulated by leukotriene B4
5. The pivotal role of the Leu-CAM and ICAM molecules in human leukocyte adhesion
6. Identification of an inducible endothelial-leukocyte adhesion molecule
7. PADGEM: An adhesion receptor for leukocytes on stimulated platelets and endothelial cells
8. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro
9. Increases in lung tissue expression of intercellular adhesion molecule-1 are associated with hyperoxic lung injury and inflammation in mice
10. P-selectin is upregulated early in the course of hyperoxic lung injury in mice
11. Increased soluble E-selectin is associated with lung inflammation and lung injury in hyperoxia-exposed rats
12. The role of P-selectin and ICAM-1 in acute lung injury as determined using antibodies and mutant mice
13. Role of the intercellular adhesion molecule- 1 (ICAM- 1) in endotoxin-induced pneumonia evaluated using ICAM- 1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice
14. Pulmonary edema induced by phagocytosing neutrophils: Protective effect of monoclonal antibody against phagocyte CD18 integrin
15. Intercellular adhesion molecule-1 contributes to pulmonary oxygen toxicity in mice: Role of leukocytes revisited
16. Compartmentalized roles for leukocytic adhesion molecules in lung inflammatory injury
17. Effect of antibodies against neutrophil and endothelial adhesion molecules on reperfusion injury after pulmonary ischemia
18. Mice deficient in ICAM-1 expression and with reduced CD18 expression have increases in hyperoxic lung inflammation and injury
19. Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment
20. Effect of dexamethasone therapy on fibronectin and albumin levels in lung secretions of infants with bronchopulmonary dysplasia
21. Betamethasone effects on paraquat lung toxicity
22. Oxygen toxicity in rats: Varied effect of dexamethasone treatment depending on duration of hyperoxia
23. Dexamethasone enhancement of hyperoxic lung injury in rats independent of adhesion molecule expression
24. Coexpression of GMP-140 and PAF by endothelium, stimulated by histamine or thrombin A: A juxtacrine system for adhesion and activation of neutrophils
25. Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells
26. In vivo expression of intercellular adhesion molecule 1 in type II pneumocytes during hyperoxia
27. Increased expression of tissue inhibitor of metalloproteinases (TIMP-1) and metallothionein in murine lungs after hyperoxic exposure
28. Increased adhesion molecule expression during acute lung injury
29. Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils
30. Rapid neutrophil adhesion to activated endothelium mediated by GMP-140
31. Pulmonary microvascular injury after intestinal ischemia-reperfusion: Role of P-selectin
32. P-selectin/ICAM-1 double mutant mice: Acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli
33. Retention of leukocytes in capillaries: Role of cell size and deformability
34. Physiological neutrophil sequestration in the lung: Visual evidence for localization in capillaries
35. Soluble form of P-selectin in plasma is elevated in acute lung injury
36. Differential contribution of various adhesion molecules to leukocyte kinetics in pulmonary microvessels of hyperoxia-exposed rat lungs
37. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver
38. NF-kappa B is activated during acute intimation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment
39. Tumor necrosis factor-alpha- or lipopolysaccharide-induced expression of the murine P-selectin gene in endothelial cells involves novel kappaB sites and a variant activating transcription factor/cAMP response element
40. Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-kappa B/rel family
41. A dual mechanism mediates repression of NF-kappa B activity by glucocorticoids
42. Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
43. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa-B transcription factor and HIV-1
44. Molecular responses to hyperoxia in vivo: Relationship to increased tolerance in aged rats
45. The effects of dexamethasone (DEX) and hyperoxia on the glutathione (GSH) system in rats