Non-specific antiviral activity of antisense molecules targeted to the E1 region of human papillomavirus

Antiviral Research

Volumn 48, Issue 3, 2000, Pages 187-196

  Lewis, E Jonathan ^a   Agrawal, Sudhir ^b   Bishop, Jill ^a   Chadwick, Jenny ^a   Cristensen, Neil D ^c   Cuthill, Scott ^a   Dunford, Paul ^a   Field, A Kirk ^b   Francis, John ^a   Gibson, Vivien ^a   Greenham, Anna K ^a   Kelly, Fiona ^a   Kilkushie, Robert ^b   Kreider, John W ^c   Mills, John S ^a   Mulqueen, Michael ^a   Roberts, Noel A ^a   Roberts, Peter ^b   Szymkowski, David E ^a  

^a ROCHE PRODUCTS LTD   (United Kingdom)

^b HYBRIDON INC   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Antisense; HPV11; HPV40; Non specific antiviral; Oligonucleotides; Papillomavirus

Indexed keywords

ADENINE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONDYLOMA; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PREPUCE; PRIORITY JOURNAL; VIROGENESIS; WART VIRUS; XENOGRAFT;

ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HERPESVIRIDAE INFECTIONS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MUROMEGALOVIRUS; OLIGONUCLEOTIDES, ANTISENSE; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; SKIN TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS; TUMOR VIRUS INFECTIONS; VIRAL PROTEINS;

CYTOMEGALOVIRUS; HUMAN PAPILLOMAVIRUS; PAPILLOMAVIRUS;

EID: 0034494311     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(00)00129-7     Document Type: Article

References (16)

1. Antisense oligonucleotides: Towards clinical trials
2. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
3. Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumour-derived and virus-infected cells
4. Coinfection of human foreskin fragments with multiple human papillomavirus types (HPV11, -40, LVX82/MM7) produces regionally separate HPV infections within the same athymic mouse xenograft
5. Murine cytomegalovirus
6. Laboratory production in vivo of infectious human papillomavirus type 11
7. CpG motifs in bacterial DNA trigger direct B-cell activation
8. Epidemiology of genital human papillomavirus infection
9. Activation of human B cells by phosphorothioate oligodeoxynucleotides
10. Genital human papillomavirus infection
11. An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defence
12. Identification of an antisense oligonucleotide with in vivo activity against human papillomavirus. 1. In vitro evaluation of oligonucleotides
13. Imiquimod 5% cream (Aldera™)
14. Two classes of human papillomavirus type 16 EI mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins
15. Effect of different chemically modified oligodeoxynucleotides on immune stimulation
16. Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice