Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice

Genesis (United States)

Volumn 28, Issue 3-4, 2000, Pages 135-142

  Novak, Anton ^a   Guo, Caiying ^a   Yang, Wenyi ^a   Nagy, Andras ^b,c   Lobe, Corrinne G ^a,c  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Eye primordium; Otx2; Pax6; Retinal progenitor cells; Rx; Six3; Small eye

Indexed keywords

GENE PRODUCT; PROTEIN RX; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SIX3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; EYE DEVELOPMENT; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; MOUSE; NEUROECTODERM; NONHUMAN; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RETINA CELL; STEM CELL;

EID: 0034490095     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1526-968X(200011/12)28:3/4<135::AID-GENE70>3.0.CO;2-P     Document Type: Article

References (35)

1. Role of XRx1 in Xenopus eye and anterior brain development
2. Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila
3. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system
4. Pax6 induces ectopic eyes in a vertebrate
5. Exogenous retinoic acid induces anterior ectopic expression of murine Hox-2 gene in vivo
6. The fate map of the cephalic neural primordium at the presomitic to the 3-somite stage in the avian embryo
7. Mapping of the presumptive brain regions in the neural plate of Xenopus laevis
8. Rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
9. Evolution of homeobox genes: Q50 paired-like genes founded the paired class
10. The master control gene for morphogenesis and evolution of the eye
11. Pax6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects
12. The role of Pax-6 in eye and nasal development
13. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
14. Mutations at the Pax6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly
15. Missense mutations in the most ancient residues of the Pax6 paired domain underlie a spectrum of human congenital eye malformations
16. Mouse Small eye results from mutations in a paired-like homeobox-containing gene
17. Molecular regulators involved in vertebrate eye development
18. Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk
19. The human PAX6 gene is mutated in two patients with aniridia
20. The Rx homeobox gene is essential for normal vertebrate development
21. Current views on eye development
22. Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development
23. The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos
24. The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions
25. Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans
26. Sine oculis is a homeobox gene required for Drosophila visual system development
27. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulation mouse embryo
28. Forebrain patterning defects in Small eye mutant mice
29. Formation of Rathke's pouch requires dual induction from the diencephalon
30. Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region
31. The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes
32. The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye
33. Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode
34. Giant eyes in Xenopus laevis by overexpression of XOptx2