Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells

Neoplasia

Volumn 2, Issue 6, 2000, Pages 523-530

  Zhang, Zhonghua ^a   Sheng, Hongmiao ^a   Shao, Jinyi ^a   Beauchampt, R Daniel ^a,b   DuBois, Raymond N ^a,b,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cyclooxygenase; Gene regulation; MAPK; Stabilization

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CERAMIDE; CHENODEOXYCHOLIC ACID; CYCLOOXYGENASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE CONTROL; INTESTINE EPITHELIUM CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CERAMIDES; CHENODEOXYCHOLIC ACID; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, DOMINANT; INTESTINAL MUCOSA; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER;

EID: 0034489934     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.neo.7900117     Document Type: Article

References (60)

1. Prostaglandin endoperoxide synthase: Structure and catalysis
2. Prostaglandin endoperoxide H synthases (cyclooxygenases) -1 and -2
3. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester
4. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/ cyclooxygenase homologue
5. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines
6. Cyclooxygenase regulates angiogenesis induced by colon cancer cells
7. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
8. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
9. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
10. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis
11. 2 gene
12. Aspirin use and reduced risk of fatal colon cancer
13. Aspirin and the risk of colorectal cancer in women
14. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
15. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2
16. Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA
17. Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases
18. HGF triggers activation of the COX-2 gene in rat gastric epithelial cells: Action mediated through the ERK2 signaling pathway
19. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum
20. v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor
21. Rapid and transient induction of cyclo-oxygenase 2 by epidermal growth factor in human amnionderived WISH cells
22. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway
23. Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal, regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways
24. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element
25. Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues
26. An E-box region within the prostaglandin endoperoxide synthase-2 (PGS-2) promoter is required for transcription in rat ovarian granulosa cells
27. v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element
28. Transcriptional roles of nuclear factor kappa B and nuclear factorinterleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
29. Transcriptional regulation of the cyclooxygenase-2 gene in activated mast cells
30. Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/ mitogen-activated protein kinase-dependent pathway
31. Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1beta: Involvement of p38 mitogen-activated protein kinase
32. Induction of cyclooxygenase-2 by the activated MEKK1, SEK1/MKK4, p38 mitogen-activated protein kinase pathway
33. Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages
34. Promoting effect of bile acids on the chemical transformation of C3H/10T1/2 fibroblasts in vitro
35. Effect of high-risk diets for colon carcinogenesis on intestinal mucosal and bacterial beta-glucuronidase activity in F344 rats
36. Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N-nitro-N-nitrosoguanidine in rats
37. Large-bowel carcinogenesis: Fecal constituents of populations with diverse incidence rates of colon cancer
38. Dihydroxy bile acids activate the transcription of cyclooxygenase-2
39. Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure
40. 2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide
41. An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis
42. Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways
43. Identification of a common nucleotide sequence in the 3′untranslated region of mRNA molecules specifying inflammatory mediators
44. Structure of the human cyclo-oxygenase-2 gene
45. Characterization of the human gene PTGS2 encoding prostaglandin-endoperoxide synthase 2
46. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
47. Regulation of interleukin (IL)-11 gene expression in IL-1 induced primate bone marrow stromal cells
48. Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins
49. Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation
50. 2 release by dexamethasone occurs by transcriptional and posttranscriptional mechanisms involving loss of polyadenylated mRNA
51. Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha
52. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
53. Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats
54. Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: Implications for colon carcinogenesis
55. Bile acids, non-phorbol-ester-type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29
56. Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling
57. Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids
58. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase
59. Bombesinstimulated ceramide production and MAP kinase activation in rabbit rectosigmoid smooth muscle cells
60. Alternate COX-2 transcripts are differentially regulated: Implications for post-transcriptional control