A preponderance of circulating basic isoforms is associated with decreased plasma half-life and biological to immunological ratio of gonadotropin-releasing hormone-releasable luteinizing hormone in obese men

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 12, 2000, Pages 4603-4610

  Castro Fernandez C ^a   Olivares, A ^a   Soderlund D ^a   Lopez Alvarenga J C ^a   Zambrano, E ^a   Veldhuis, J D ^a   Ulloa Aguirre, A ^a   Mendez J P ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTRONE; GONADORELIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; ESTRONE BLOOD LEVEL; GLYCOSYLATION; HALF LIFE TIME; HORMONAL REGULATION; HUMAN; HYPOGONADISM; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; MALE; OBESITY; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL;

ADULT; CYCLIC AMP; ESTRADIOL; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HALF-LIFE; HUMANS; HYDROGEN-ION CONCENTRATION; ISOMERISM; LUTEINIZING HORMONE; MALE; OBESITY; RADIOIMMUNOASSAY;

EID: 0034489817     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.12.4603     Document Type: Article

References (57)

1. Low serum testosterone and sex hormone binding globulin in massively obese men
2. Depressed plasma testosterone and fractional binding of testosterone in obese males
3. Plasma free and non-sexhormone-binding-globulin-bound testosterone are decreased in obese men in proportion to their degree of obesity
4. Effect of obesity and body fat distribution on sex hormones and insulin in men
5. Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men
6. An inverse relationship between body weight and the activity of the steroid binding β-globin in human plasma
7. The effect of weight loss on reproductive hormones in obese men
8. Mild hypogonadotropic hypogonadism in obese men
9. Hypothalamic and pituitary dysfunction in obese males
10. Role of carbohydrates in glycoprotein hormone signal transduction
11. Glycoprotein hormones: Glycobiology of gonadotrophns, thyrotrophin and free α subunit
12. Analytical and clinical significance of peptide hormone heterogeneity with particular reference to growth hormone and luteinizing hormone in serum
13. Role of glycosylation in function of follicle-stimulating hormone
14. Effects of synthetic GnRH on incorporation of radioactive glucosamine, and amino acids into LH and total protein by rat pituitaries in vitro
15. Biosynthesis, glycosylation, and secretion of rat luteirdzing hormone α subunit and β-subunits: Differential effects of orchiectomy and GnRH
16. Sialyltransferase messenger ribonucleic acid increases in thyrotrophs of hypothyroid mice: An in situ hybridization study
17. β1,4-Galactosyltransferase and α-mannosidase-II messenger ribonucleic acid levels increase with different kinetics in thyrotrophs of hypothyroid mice
18. Estrogen modulates expression of the glycosyltransferases that synthesize sulfated oligosaccharides on lutropin
19. Gonadotroph secretion in response to low, and high doses of LRF in normal and hypogonadal women (functional disparity of the gonadotrophs)
20. Qualitative and quantitative differences in hLH species in the first and second LH release induced by continuous stimulation with LHRH in normal menstrual cycle as assessed by isoelectric focusing
21. Preferential release of bioactive luteinizing hormone in response to endogenous and low dose exogenous gonadotropin-releasing hormone pulses in man
22. A preponderance of basic luteinizing hormone (LH) isoforms accompanies inappropriate hypersecretion of both basal and pulsatile LH in adolescents with polycystic ovarian syndrome
23. The reactivity of different luteinizing hormone and follicle-stimulating hormone standards and preparations in the WHO matched reagents for enzyme-linked immunoassays of gonadotrophins
24. Dynamics of basal and gonadotropin-releasing hormone-releasable serum follicle-stimulating hormone charge isoform distribution throughout the human menstrual cycle
25. Self-priming effect of luteinizing hormone-human chorionic gonadotropin (hCG) upon the biphasic testicular response to exogenous hCG. I. Serum testosterone profile
26. Luminiscence luteinizing hormone/choriogonadotropin (LH/CG) bioassay: Measurement of serum bioactive LH/CG during early pregnancy in human and macaque
27. Receptor binding activity and in vitro biological activity of the human ESH charge isoforms as disclosed by heterologous and homologous assay systems. Implications for the structurefunction relationship of the ESH variants
28. Physiological attributes of endogenous bioactive luteinizing hormone secretory bursts in man
29. Deconvolution analysis of hormone data
30. Specific methodological approaches to selected contemporary issues in deconvolution analysis of pulsatile neuroendocrine data
31. Complicating effects of highly correlated model variables on nonlinear least-squares estimates of unique parameter values and their statistical confidence intervals: Estimating basal secretion and neurohormone half-life by deconvolution analysis
32. A luteinizing hormone-releasing hormone agonist decreases biological activity and modifies chromatographic behavior of luteinizing hormone in man
33. Acute androgen receptor blockade increases luteinizing hormone secretory activity in men
34. Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men
35. More basic forms of both human follicle-stimulating hormone, and luteinizing hormone in serum at midcycle compared with the follicular and luteal phase
36. Glycoform composition of serum gonadotrophins throughout the normal menstrual cycle and in the post-menopausal state
37. 17β-Estradiol counteracts the formation of the more acidic isoforms of follicle-stimulating hormone and luteinizing hormone after menopause
38. Effect of chronic oral administration of 17β-oestradiol and norethisterone on the isoforms of serum gonadotrophins in post-menopausal women
39. Pituitary glycoprotein hormone oligosaccharides: Structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin
40. Oestrogens regulate pituitary α2,3-sialyltransferase messenger ribonucleic acid levels in the female rat
41. Ovine luteinizing hormone heterogeneity: Androgens increase the percentage of less basic isohormones
42. Less acidic forms of luteinizing hormone are associated with lower testosterone secretion in men on haemodialysis treatment
43. Leptin's actions on the reproducive axis: Perspectives and mechanisms
44. The role of sialic acid in determining the survival of glycoprotein hormones in the circulation
45. In vitro and in vivo bioactivity of recombinant human follicle-stimulating hormone and partially deglycosylated variants secreted by transfected eukariotic cell lines
46. 4-4GalNAcβ1,4GlcNAcβ1,2Manα that mediates rapid clearance of lutropin
47. Both of the β-subunit carbohydrate residues of follicle-stimulating hormone determine the metabolic clearance rate and in vivo potency
48. In vivo bioactivities and clearance patterns of highly purified human luteinizing hormone isoforms
49. 4-4-GalNAcβ1,4GlcNAcβ1, 2Manα-specific receptor from rat liver
50. Structural and functional characterization of hFSH and hLH isoforms
51. The pituitary gland secretes in bursts: Appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations
52. Pathophysiological features of the pulsatile secretion of biologically active luteinizing hormone in man
53. Joint recovery of pulsatile and basal hormone secretion by stochastic nonlinear random-effects analysis
54. Follicle-stimulating isohormones: Characterization and physiological relevance
55. A naturally occurring basically charged human follicle-stimulating hormone (ESH) variant inhibits FSH-induced androgen aromatization and tissue-type plasminogen activator enzyme activity in vitro
56. Modulation of serum and pituitary luteinizing hormone bioactivity by androgen in the rat
57. Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis