Dopamine transporter and catechol-O-methyltransferase activities are required for the toxicity of 1-(3′,4′-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Research in Toxicology

Volumn 13, Issue 12, 2000, Pages 1294-1301

  Kawai, Hiroshi ^a,c   Kotake, Yaichiro ^b   Ohta, Shigeru ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3',4' DIHYDROXYBENZYL) 1,2,3,4 TETRAHYDROISOQUINOLINE DERIVATIVE; CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; DOPAMINE TRANSPORTER; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; DRUG INDUCED DISEASE; DRUG METABOLISM; DRUG STRUCTURE; DRUG UPTAKE; EMBRYO; ENZYME ACTIVITY; NONHUMAN; PARKINSON DISEASE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARRIER PROTEINS; CATECHOL O-METHYLTRANSFERASE; CELL SURVIVAL; CELLS, CULTURED; CORPUS STRIATUM; DOPAMINE; MALE; MESENCEPHALON; NEURONS; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SYNAPTOSOMES; TRETOQUINOL;

ANIMALIA;

EID: 0034489105     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000047y     Document Type: Article

References (2)

1. Collins, M. A. (1983) Mammalian alkaloids. In The Alkaloids (Brossi, A., Ed.) Vol. 21, pp 329-358, Academic Press, New York.
2. Langsten, J. W., Ballard, P., Tetrud, J. W., and Irwin, I. (1983) Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979-980.