4-Hydroxy-2-nonenal and ethyl linoleate form N2,3-ethenoguanine under peroxidizing conditions

Chemical Research in Toxicology

Volumn 13, Issue 12, 2000, Pages 1243-1250

  Ham, Amy Joan L ^a   Ranasinghe, Asoka ^b   Koc, Hasan ^b   Swenberg, James A ^a,b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,N2 ETHENOGUANINE; 1,N6 ETHENOADENINE; 3,N4 ETHENOCYTOSINE; 4 HYDROXYNONENAL; BENZYL DERIVATIVE; CARBON 13; DEOXYADENOSINE DERIVATIVE; DEOXYRIBOSE; DNA; LINOLEIC ACID ETHYL ESTER; N2,3 ETHENOGUANINE; TERT BUTYL HYDROPEROXIDE; THYMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA ADDUCT; DNA ALKYLATION; GAS CHROMATOGRAPHY; IMMUNOAFFINITY CHROMATOGRAPHY; LIPID PEROXIDATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MUTAGENICITY;

ALDEHYDES; ANIMALS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GUANOSINE; LINOLEIC ACIDS; LIPID PEROXIDATION; MUTAGENS;

EID: 0034488260     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0001124     Document Type: Article

References (6)

1. Bartsch, H., Barbin, A., Marion, M. J., Nair, J., and Guichard, Y. (1994) Formation, detection, and role in carcinogenesis of ethenobases in DNA. Drug Metab. Rev. 26, 349-371.
2. 2,3-ethenoguanosine, is a highly efficient mutagen in transcription. Carcinogenesis 8, 745-747.
3. Swenberg, J. A., La, D. K., Scheller, N. A., and Wu, K. Y. (1995) Dose-response relationships for carcinogens. Toxicol. Lett. 8283, 751-756.
4. 2,3-ethenoguanine in rat tissue DNA. Carcinogenesis 11, 1287-1292.
5. 4ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole. Biochemistry 32, 12793-12801.
6. 2,3-ethenoguanine produces G-A transitions in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 88, 9974-9978.