Trp42 rotamers report reduced flexibility when the inhibitor acetyl-pepstatin is bound to HIV-1 protease

Protein Science

Volumn 9, Issue 11, 2000, Pages 2232-2245

  Ullrich, Beáta ^a   Laberge, Monique ^a   TÖlgyesi, Ferenc ^a   Fidy, Judit ^a   Szeltner, Zoltán ^b   Polgár, LÁszlö ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

500 ps molecular dynamics; Acrylamide quenching; Dihedral trajectories; Dynamics influenced by inhibitor; Ground state heterogeneity; Trp fluorescence; Trp rotamers

Indexed keywords

ACRYLAMIDE; APOENZYME; MONOMER; N ACETYLPEPSTATIN; PROTEIN DERIVATIVE; PROTEIN TRP42; PROTEINASE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ESCHERICHIA COLI; FLUORESCENCE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION;

ACRYLAMIDE; COMPUTER SIMULATION; ESCHERICHIA COLI; HIV PROTEASE; KINETICS; MODELS, MOLECULAR; MUTAGENESIS; PEPSTATINS; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; TIME FACTORS; TRYPTOPHAN;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034487443     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.11.2232     Document Type: Article

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