Peroxidase-catalyzed oxidative damage of DNA and 2′-deoxyguanosine by model compounds of lipid hydroperoxides: Involvement of peroxyl radicals

Chemical Research in Toxicology

Volumn 13, Issue 12, 2000, Pages 1199-1207

  Adam, Waldemar ^a   Kurz, Annemarie ^a   Saha Möller, Chantu R ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIMETHYL 3 HYDROPEROXY 1 BUTENE; 3 HYDROPEROXY 1 BUTENE; 4,8 DIHYDRO 4 HYDROXY 8 OXO 2' DEOXYGUANOSINE; 5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; 7,8 DIHYDRO 8 OXO 2' DEOXYGUANOSINE; DEOXYGUANOSINE; DNA; ETHYL OLEATE HYDROPEROXIDE; HORSERADISH PEROXIDASE; LACTOPEROXIDASE; LINOLEIC ACID HYDROPEROXIDE; LIPID HYDROPEROXIDE; PEROXIDASE; PEROXY RADICAL; SCAVENGER; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DECOMPOSITION; DNA DAMAGE; DNA STRAND BREAKAGE; ELECTRON SPIN RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID PEROXIDATION; OXIDATION;

ANIMALS; CATTLE; COPRINUS; DEOXYGUANOSINE; DNA DAMAGE; DNA, SUPERHELICAL; FREE RADICAL SCAVENGERS; FREE RADICALS; HORSERADISH PEROXIDASE; LACTOPEROXIDASE; LIPID PEROXIDES; MODELS, CHEMICAL; OXIDATION-REDUCTION;

ARMORACIA RUSTICANA; COPRINUS; LETHRINIDAE;

EID: 0034486979     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0001880     Document Type: Article

References (5)

1. Porter, N. A. (1986) Mechanisms for the autoxidation of polyunsaturated lipids. Acc. Chem. Res. 19, 262-268.
2. Esterbauer, H., Eckl, P., and Ortner, A. (1990) Possible mutagens derived from lipids and lipid precursors. Mutat. Res. 238, 223-233.
3. Inoue, S. (1984) Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid. FEES Lett. 172, 231-234.
4. Ueda, K, Kobayashi, S., Morita, J., and Komano, T. (1985) Sitespecific DNA damage caused by lipid peroxidation products. Biochim. Biophys. Acta 824, 341-348.
5. Yang, M. H., and Schaich, K. M. (1996) Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes. Free Radical Biol. Med. 20, 225-236.